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Indian medicinal phytocompounds for targeting apoptosis and high-penetrance genes in triple-negative breast cancer: an in-silico exploration
Indian medicinal phytocompounds for targeting apoptosis and high-penetrance genes in triple-negative breast cancer: an in-silico exploration
Triple-negative breast cancer (TNBC) presents a significant therapeutic challenge due to its aggressive nature, lack of ho...
Evolutionary and structural insights into DNMTs and TETs: decoding their functional heterogeneity and oncogenic roles in methylation regulation
Evolutionary and structural insights into DNMTs and TETs: decoding their functional heterogeneity and oncogenic roles in methylation regulation
DNA methylation in mammals is dynamically regulated by DNMTs and TETs. Despite their critical roles, comparative structura...
Immune gene expression in salmon keratocytes upon bacterial exposure
Immune gene expression in salmon keratocytes upon bacterial exposure
Pathogens pose a significant threat to farmed salmon, adversely affecting their health and welfare, which results in subst...
The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs)
The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs)
Bioengineering of human teeth for replacement is an appealing regenerative approach in the era of gene therapy. Developmen...
Transient activation of YAP/TAZ confers resistance to morusin-induced apoptosis
Transient activation of YAP/TAZ confers resistance to morusin-induced apoptosis
The Hippo signaling pathway involves a kinase cascade that controls phosphorylation of the effector proteins YAP and TAZ, ...
BRAF regulates circPSD3/miR-526b/RAP2A axis to hinder papillary thyroid carcinoma progression
BRAF regulates circPSD3/miR-526b/RAP2A axis to hinder papillary thyroid carcinoma progression
Papillary thyroid carcinoma (PTC) is a common malignant tumor. BRAFV600E mutation has become a common molecular event in P...
Method for determining of cytotoxicity based on the release of fluorescent proteins
Method for determining of cytotoxicity based on the release of fluorescent proteins
This paper describes a method for determining the cytotoxicity of chemical compounds based on the detection of fluorescent...
Assessment of XCI skewing and demonstration of XCI escape region based on single-cell RNA sequencing: comparison between female Grave’s disease and control
Assessment of XCI skewing and demonstration of XCI escape region based on single-cell RNA sequencing: comparison between female Grave’s disease and control
The reactivation and loss of mosaicism hypothesis due to X chromosome inactivation (XCI) skewing and escape could influenc...
Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells
Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells
Breast cancer is the most common malignant tumour in women. The early silk-splitting inhibitor protein 1 Emi1 is responsib...
TNFα induces Caspase-3 activity in hematopoietic progenitor cells CD34+, CD33+, and CD41 + of myelodysplastic syndromes
TNFα induces Caspase-3 activity in hematopoietic progenitor cells CD34+, CD33+, and CD41 + of myelodysplastic syndromes
Cytopenia is the primary feature of Myelodysplastic Syndrome, even in the presence of hypercellular bone marrow. TNFα...
Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of cells from nasal polyps
Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of cells from nasal polyps
Epithelial cells are an important part of the pathomechanism in chronic rhinosinusitis with nasal polyps. It is therefore ...
From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway
From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway
The morphogenetic process of apical constriction, which relies on non-muscle myosin II (NMII) generated constriction of ap...
Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats
Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats
Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to...
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
Patients with intellectual disabilities are shown to have a limited capacity for cooperation, communication,and other biol...
Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro
Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro
Inflammation plays a crucial role in the progression of Subacute Ruminal Acidosis (SARA). The experiment was designed to i...
D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice
D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice
Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have sugge...
Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer
Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in t...
BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway
BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway
Bone morphogenetic protein 9 (BMP9) has been shown to regulate processes such as angiogenesis, endothelial dysfunction, an...
A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78
A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78
Cells can die through a process called apoptosis in both pathological and healthy conditions. Cancer development and progr...
Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance
Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance
Emodin and aloe-emodin are two anthraquinones having positive effects in wound healing. However, their mechanism of action...
Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress
Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress
Renal ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI). Dysfunction of E74-like ETS transcr...
Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells
Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells
Janus kinase 3 (JAK3) is a member of the JAK family of tyrosine kinase proteins involved in cytokine receptor-mediated int...
Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2
Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2
DYX1C1 (DNAAF4) and DCDC2 are two of the most replicated dyslexia candidate genes in genetic studies. They both have demon...
Myogenic differentiation of human myoblasts and Mesenchymal stromal cells under GDF11 on Poly-ɛ-caprolactone-collagen I-Polyethylene-nanofibers
Myogenic differentiation of human myoblasts and Mesenchymal stromal cells under GDF11 on Poly-ɛ-caprolactone-collagen I-Polyethylene-nanofibers
For the purpose of skeletal muscle engineering, primary myoblasts (Mb) and adipogenic mesenchymal stem cells (ADSC) can be...
SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation
SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation
The platelet-derived growth factor (PDGF) family of ligands exerts their cellular effects by binding to α- and β...
Myogenic differentiation of human myoblasts and Mesenchymal stromal cells under GDF11 on NPoly-ɛ-caprolactone-collagen I-Polyethylene-nanofibers
Myogenic differentiation of human myoblasts and Mesenchymal stromal cells under GDF11 on NPoly-ɛ-caprolactone-collagen I-Polyethylene-nanofibers
For the purpose of skeletal muscle engineering, primary myoblasts (Mb) and adipogenic mesenchymal stem cells (ADSC) can be...
Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact
Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact
Cytochrome P450 4F2 (CYP4F2) enzyme is a member of the CYP4 family responsible for the metabolism of fatty acids, therapeu...
Using RNA-seq to identify suitable housekeeping genes for hypoxia studies in human adipose-derived stem cells
Using RNA-seq to identify suitable housekeeping genes for hypoxia studies in human adipose-derived stem cells
Hypoxic culture conditions have been used to study the impact of oxygen deprivation has on gene expression in a number of ...
SCAT8/miR-125b-5p axis triggers malignant progression of nasopharyngeal carcinoma through SCARB1
SCAT8/miR-125b-5p axis triggers malignant progression of nasopharyngeal carcinoma through SCARB1
Nasopharyngeal carcinoma is a tumor with high malignancy and poor prognosis, which severely affects the health of the pati...
ARNTL2 upregulation of ACOT7 promotes NSCLC cell proliferation through inhibition of apoptosis and ferroptosis
ARNTL2 upregulation of ACOT7 promotes NSCLC cell proliferation through inhibition of apoptosis and ferroptosis
Recent studies have reported that the circadian transcription factor aryl hydrocarbon receptor nuclear translocator like 2...
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