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The methylation-expression correlation of autophagy-related genes in colorectal cancer patients from southern Iran
Colorectal cancer (CRC), which has high mortality and increasing morbidity is a major concern worldwide. The autophagy pat...
A systematic in-silico functional and structural analysis reveals deleterious nsSNPs in the Human CSF1R Gene
Colony Stimulating Factor-1 Receptor (CSF1R) is a tyrosine kinase transmembrane receptor that plays a vital role in innate...
SPIN.DOC induces cellular transformation of NIH3T3 normal mouse fibroblast cells
SPIN.DOC was discovered as a transcriptional co-repressor of wingless related integration site (WNT) pathway. However, it ...
In silico exploring of the epigenetic factors in teratozoospermia: A focus on IGF2BP2
Teratozoospermia is an abnormal sperm morphology that is a common cause of male infertility. Epigenetic factors have been ...
Molecular identification of KRAS, BRAF, and PIK3CA mutations in colorectal cancer patients from the Kurdistan region of Iraq
Colorectal cancer (CRC) emerged due to genetic mutations that fuel tumor development and influence patient outcomes. This ...
Role of VOPP1 in regulation of Paclitaxel response and EMT process during ovarian tumor progression
Ovarian cancer (OC) is one of the most common malignancies of the genitourinary system in women that has a high mortality ...
Genetic polymorphisms of GSTM1 and GSTT1 genes: effects on susceptibility to formaldehyde-induced hematotoxicity
Formaldehyde (FA) is a known human carcinogen for the upper respiratory tract. However, its hematotoxicity remains unclear...
Prediction of microRNAs affecting the syncytin-1 (HERV-W) and syncytin-2 (HERV-FRD) genes regulation in endometriosis and miscarriage
Abnormal expression levels of microRNAs are associated with numerous diseases in the female reproductive tract. A small su...
Integrative computational approach to farnesyltransferase inhibition toward anti-liver cancer drug candidate from Syzygium cumini essential oils
Farnesyltransferase plays a critical role in the post-translational modification of mammalian proteins, including the Ras ...
Molecular dynamics simulation of thermal activation of human TRPV1
TRPV1 (Transient Receptor Potential Vanilloid 1) is a non-selective ion channel that responds to various thermal, chemical...
Wharton's jelly mesenchymal stem cell-derived conditioned media inhibits colon cancer cells via activating AMPK/mTOR-mediated autophagy
Prior studies have shown that conditioned media derived from Wharton's jelly mesenchymal stem cells (WJ-CM) have anti...
Analysis of amino acid residues affecting the transcriptional activity of nuclear factor Ya
Nuclear factor Y (NF-Y) is a heterotrimeric transcription factor essential for regulating genes involved in lipid metaboli...
CPUK02 sensitizes U87 glioblastoma cell lines to TMZ treatment via autophagy flux inhibition
Adjuvant chemotherapy with TMZ (Temozolomide) does not improve the survival of patients suffering from GBM (Glioblastoma)....
The possibility of prognostic and functional values of the 8q24 and 20q13 chromosomal bands in colorectal cancer
Colorectal cancer (CRC) remains a major global health concern, especially given its increasing incidence among younger ind...
Artificial intelligence and genomic data privacy: Balancing innovation with security
Artificial intelligence (AI) has emerged as one of the most transformative technologies in contemporary medicine and biolo...
Comprehensive computational analysis of deleterious nsSNPs in PTEN gene for structural and functional insights
Single nucleotide polymorphisms (SNPs) are pivotal in understanding the genetic basis of complex disorders. Among them, no...
Gene co-expression network analysis reveals relationship between leukocyte fraction and genomic instability in dedifferentiated liposarcoma
Dedifferentiated Liposarcoma (DDLPS) is one of the common subtypes of liposarcoma that is considered a highly malignant ca...
Breast cancer susceptibility is associated with Cyclin D1 single nucleotide polymorphisms in Iran: A case-control study
Breast cancer (BC) is the main cause of cancer-related death in women worldwide. We evaluated the association between the ...
The importance of TP53 status in cancer therapy: The example of chronic lymphocytic leukemia
The TP53 gene encodes the tumor suppressor protein p53, which plays a critical role in genomic stability and cell cycle re...
Comment on: IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study
Dear Editor,I recently read an elegant study by Abdalla1 and Hamdan (2025) published in the Molecular Biology Research Com...
The effect of chemotherapeutic agents on epidermal neural crest stem cells
Human Epidermal Neural Crest Stem Cells (hEPI-NCSCs), as a transient population of multipotent migratory stem cells can di...
Clinical relevance of plasma-derived exosomal long non-coding RNAs (lncRNAs) CCAT1 and XIST in colorectal cancer patients
The expression level of exosomal long non-coding RNAs (lncRNAs) can be relevant for clinical diagnostic approaches. The ob...
Investigation methylation status of tumor suppressor gene NR4A1 and NR4A3 and frequency of rs1569686 polymorphism of DNMT3B gene in patients with acute myeloid leukemia
Acute myeloid leukemia (AML) is the most frequent type of leukemia among adults. Investigating AML heterogeneity based on ...
Pathogenic variants of BUB1 and BUBR1 genes are not prioritized in screening tests of couples with aborted aneuploid fetuses
Chromosome aberrations certainly aneuploidie are the cause of the majority of spontaneous abortions in humans. BUB1 (buddi...
Computational analysis of Ayurvedic herbs to explore their potential role as anti-cervical cancer agents
Cervical cancer is one of the common types of cancer in women. Treatment regimens include use of chemotherapy but it leads...
Effect of 30-day Ramadan fasting on autophagy pathway and metabolic health outcome in healthy individuals
During Ramadan, Muslims fast to spiritually prepare their bodies and spirits. The autophagy pathway restores cellular home...
A review on diabetes and oral cancer: Molecular links and implications
Diabetes mellitus has been linked to an increased risk of oral cancer, with hyperglycemia and chronic inflammation contrib...
Allele and genotype frequencies of β-lactoglobulin gene using PCR-RFLP in Algerian local cattle populations
Milk protein genetic polymorphisms are associated with economically important traits in dairy cattle. The objective of thi...
In-silico structural analysis of Heterocephalus glaber amyloid beta: an anti-Alzheimer's peptide
Heterocephalus glaber, known as the Naked mole-rat, has an extraordinary immunity to Alzheimer's disease. The patholo...
MicroRNAs targeting CDKN2A gene as a potential prognostic marker in head and neck squamous cell carcinoma
Epigenetic factors are known to markedly influence the functions of a gene by modification of transcripts, via methylation...
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