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Chemoproteomic profiling reveals histone H4 dopaminylation inhibiting cell growth
Chemoproteomic profiling reveals histone H4 dopaminylation inhibiting cell growth
Dopaminylation, the covalent attachment of dopamine to the side chain of glutamine in proteins, represents a newly charact...
Proteolysis activity mapping and substrate discovery platform for identifying tumor-activated biosensors
Proteolysis activity mapping and substrate discovery platform for identifying tumor-activated biosensors
Dysregulated extracellular proteolytic activity is a prominent hallmark of cancer and can thus be exploited for tumor dete...
MEK inhibitors loosen RAF’s grip
MEK inhibitors loosen RAF’s grip
A study reveals that the conformational state of the RAF protein governs sensitivity to a next-generation class of RAF inh...
MEK interactions tune RAF kinase sensitivity to conformation-selective inhibition
MEK interactions tune RAF kinase sensitivity to conformation-selective inhibition
RAF kinases are key effectors in the RAS–RAF–MEK–ERK signaling pathway, making them important targets fo...
Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation
Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation
Proteolysis-targeting chimeras (PROTACs) and molecular glue degraders (MGDs) target proteins for degradation by co-opting ...
How Cinchona builds quinine
How Cinchona builds quinine
For centuries, cinchona alkaloids such as quinine have shaped the history of both medicine and organic chemistry; yet, how...
A TerminaTOR of mTORC1 signaling
A TerminaTOR of mTORC1 signaling
A genetically encodable and targetable protein fragment derived from PRAS40 inhibits mTOR complex 1 (mTORC1) signaling in ...
Genetically targeted mTORC1 inhibitor reveals transcriptional control by nuclear mTORC1
Genetically targeted mTORC1 inhibitor reveals transcriptional control by nuclear mTORC1
Mechanistic target of rapamycin complex 1 (mTORC1) is a nutrient sensor that integrates diverse inputs to regulate protein...
Publisher Correction: Discovery and biological characterization of geranylated RNA in bacteria
In the version of the article initially published, in the “Geranylation affects codon bias and frameshifting” section, the...
Dimerization for activation
Dimerization for activation
By combining cryo-electron microscopy, AlphaFold 2 predictions, molecular dynamics simulations and various biochemical ass...
Tracking lipids
The eukaryotic cell produces many different species of lipids with different characteristics, which have a variety of role...
Lost in translation
Disrupted proteostasis can lead to the accumulation of damaged proteins and protein aggregates and a loss of correlation b...
Engineering synthetic agonists for targeted activation of Notch signaling
Engineering synthetic agonists for targeted activation of Notch signaling
Notch signaling regulates cell fate decisions and has context-dependent tumorigenic or tumor suppressor functions. Althoug...
Molecular basis for the regulation of membrane proteins through preferential lipid solvation
Molecular basis for the regulation of membrane proteins through preferential lipid solvation
The mechanism by which lipids regulate membrane proteins remains an open question. While many protein structures reveal as...
Author Correction: Navigating condensate micropolarity to enhance small-molecule drug targeting
These authors contributed equally: Jian Ouyang, Junlin Chen.Department of Biochemistry and Molecular Biology, School of Ba...
IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers
IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers
Chimeric antigen receptor (CAR)-T cell therapies have shown remarkable efficacies for treating otherwise intractable cance...
Mechanistic insights and approaches for beta cell regeneration
Mechanistic insights and approaches for beta cell regeneration
Diabetes is characterized by variable loss of insulin-producing beta cells, and new regenerative approaches to increasing ...
ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation
ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation
As an enzyme with a critical role in de novo purine synthesis, adenylosuccinate lyase (ADSL) expression is upregulated in ...
REPLACE-ing RNA through evolution
REPLACE-ing RNA through evolution
Directed evolution is commonly performed in prokaryotic or yeast systems, but platforms are needed to enhance functions in...
Programming biological communication between distinct membraneless compartments
Programming biological communication between distinct membraneless compartments
Distinct membraneless organelles within cells collaborate closely to organize crucial functions. However, biosynthetic com...
Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload
Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload
Sodium influx and overload are frequently observed in human tissue injuries. Whether sodium overload imposes a causative e...
Expanding the molecular grammar of polar residues and arginine in FUS phase separation
Expanding the molecular grammar of polar residues and arginine in FUS phase separation
A molecular grammar governing low-complexity prion-like domain phase separation (PS) has identified tyrosine and arginine ...
Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator
Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator
Measuring pharmacodynamics (PD)—the biochemical effects of drug dosing—and correlating them with therapeutic e...
Lifetime of ground conformational state determines the activity of structured RNA
Lifetime of ground conformational state determines the activity of structured RNA
Biomolecules continually sample alternative conformations. Consequently, even the most energetically favored ground confor...
Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase
Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase
Macrocyclic peptides represent promising scaffolds for chemical tools and potential therapeutics. Synthetic methods for pe...
Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM
Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM
Compact Cas9 nucleases hold great promise for therapeutic applications. Although several compact Cas9 nucleases have been ...
In search of chemical rationales
In search of chemical rationales
Small molecules and drugs are not homogenously distributed across cells, and are instead enriched in distinct subcellular ...
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity
Authors and AffiliationsDepartment of Chemistry, The University of Chicago, Chicago, IL, USATong Wu, Chang Liu, Siyuan Zou...
Characterizing the metabolomes of phase-separated condensates
Characterizing the metabolomes of phase-separated condensates
Cells contain compartments composed of phase-separated protein condensates. We find that these condensates have a unique c...
Medicine from modified mRNA
Medicine from modified mRNA
As the COVID-19 pandemic rapidly spread around the world, the scientific community desperately searched for therapeutic in...
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