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Synthesis, structural characterization, and antitumor evaluation of Pd(II) Thiosemicarbazide–Diphosphine complexes in 2D and 3D cancer models
Cancer remains one of the leading causes of death worldwide, with millions of new cases diagnosed annually. Cisplatin is a...
Design, synthesis, and antitumor mechanism investigation of iridium(III)/ruthenium(II)-vadimezan conjugates towards 4T1 cells
Breast cancer represents one of the most prevalent malignancies worldwide. Despite significant advances in breast cancer m...
NMR spectroscopic evidence that the antileishmanial drug sodium stibogluconate comprises one predominant molecular species
Volume 278, May 2026, 113237Author links open overlay panel, , Highlights•[Sb(OH)6]− and gluconate combine to form predomi...
Impact of N-terminal acetylation on Cu(I) coordination by alpha synuclein protein
Volume 278, May 2026, 113229Author links open overlay panel, , , , , , , Highlights•Acetylation of α-synuclein affects the...
Cavity acidification limits ferritin iron biomineralization
Volume 278, May 2026, 113242Author links open overlay panel, , Highlights•Directly measured ferritin cavity acidification ...
Dual HSA and DNA affinity of a free-base porphyrin nitro-ruthenium(II) complex: Spectroscopic evaluation and photocleavage studies
Metal compounds, particularly transition metal complexes, are extensively explored as a novel class of drugs for treating ...
DNA-targeting ruthenium(II) complexes that simultaneously induce tumor apoptosis and autophagy
Although cisplatin is the most widely used metal-based antitumor drug, its numerous side effects have prompted researchers...
Molybdenum(II) allyl dicarbonyl complexes with 3-(2-pyridyl)pyrazole as potential CO-releasing molecules, antibacterial and antitumoral agents
Volume 278, May 2026, 113244Author links open overlay panel, , , , , , , , , Highlights•Preparation of the complexes [Mo(η...
Ferric reductase related proteins Frp1 and Frp2 mediate reductive heme uptake in the opportunistic pathogen Candida albicans
Volume 278, May 2026, 113246Author links open overlay panel, , , Highlights•Heme uptake in Candida albicans is oxygen depe...
Multimodal insights into the anticancer activity of (alkyl-ω-ol)triphenyltin(IV) compounds: Targeting cancer pathways through cytotoxicity and transferrin-gateway interaction mechanisms
Organotin(IV) compounds represent a unique class of organometallic complexes whose biological activity originates from the...
NMR spectroscopy stability studies of Ru-IM, a prodrug candidate for triple negative breast cancer
The assessment of stability is a fundamental component of chemotherapeutic drug development [1]. Instability leading to ch...
A conserved copper-binding site in multicopper oxidases regulates the metalation of CueO from Escherichia coli
Volume 278, May 2026, 113257Author links open overlay panel, , , , , , , , Highlights•Cu8-site is putative transient coppe...
Secondary amide derivatives of Fe(III)-CDTA: Impact of ligand substitution on relaxivity, stability, and kinetic inertness
The authors declare that the data supporting the findings of this study are available within the article and its supplemen...
Zinc-porphyrin complex as multifunctional anti-AD agent: Synthesis, X-ray single crystal analysis and activity study
Alzheimer's disease (AD), a neurodegenerative disorder, currently affects about 50 million people worldwide and causes a h...
Pt(II) and Pd(II) complexes bearing 1,10-phenanthroline-based ligands: Distinct binding modes to DNA and anticancer activities
Although Pt-containing drugs such as cisplatin are excellent anticancer agents in clinical use, such drugs have severe sid...
Hydroxamic acid chelator profiles and Ga(III) complexes from siderophore synthetase-mediated synthesis using length-modulated substrates
The recombinant Salinispora tropica CNB-440 siderophore synthetase StDesD catalysed the assembly of pools of hydroxamic ac...
Synthesis, characterization, and DFT studies of isomeric homoleptic Bi (III) dithiocarbamate complexes vis-à-vis cytotoxicity in cancer cell, A549
Metal-based chemotherapeutics have long been dominated by platinum drugs such as cisplatin, carboplatin, and oxaliplatin, ...
The relevance of considering metal–ligand speciation in aquaporin modulation by cu, Zn, and V complexes with 1,10-phenanthroline ligands
Aquaporins (AQPs) are transmembrane proteins that facilitate the bidirectional transport of water, glycerol, and small sol...
An azoreductase-responsive “OFF-ON-OFF” reversible photosensitizer for highly selective antibacterial photodynamic therapy
Bacterial infections represent a leading cause of global human mortality. Conventional antibacterial strategies predominan...
Probing anion recognition in a cobalt(II) de novo designed metalloprotein
Volume 279, June 2026, 113268Author links open overlay panel, , , Highlights•A de novo cobalt(II) metalloprotein enables s...
Exploring the chemistry of H2DEDPA derivatives for [nat/68Ga]Ga3+ complexation
We report a detailed study of the coordination chemistry of acyclic hexadentate H2DEDPA derivatives towards [nat/68Ga]Ga3+...
Gold(I) complexes with NHC ligands functionalized with sulfoxide groups: Design, synthesis, in vitro studies and insights into the mechanism of action as anticancer drugs
Mononuclear silver(I) complexes of the type [AgBr(NHC)] (NHC=N-heterocyclic carbene) were prepared by reaction of the imid...
Synthesis and anticancer studies of Ru/Ir arene complexes bearing oleanolic acid in acute promyelocytic leukemia cells
In recent years, medicinal chemistry has made significant strides in exploring metal-based drug candidates across the peri...
Potent mitochondria-targeting rutheniumII and iridiumIII anticancer complexes containing hybrid N^NH-chelated ligands
Cancer remains a significant global health challenge due to its high morbidity and mortality rates, presenting an urgent p...
Structure-function relationship within helical peptoids for Cu2+ chelation in the context of Alzheimer's disease
Peptoids (N-substituted glycine oligomers) represent an excellent platform for drug development, such as selective chelato...
A molecular basis of Ferredoxin Reductase (FdxR) mutations that result in mitochondriopathies
Ferredoxin Reductase (FdxR, also referred to as Adrenodoxin Reductase) is a multidomain flavoprotein located in the inner ...
Structural studies and biological activity of the new Ni(II), Cu(II), Zn(II), Pd(II), and Ag(I) thiosemicarbazone-based complexes
Three new chloro-substituted nitrophenyl-based thiosemicarbazones, namely: HTSC-oCl, HTSC-mCl, and HTSC-pCl (where HTSC-Cl...
Mutation of an active site-adjacent residue in VIM indirectly dictates interactions with and blunts inhibition by D-captopril
Activity assays and X-ray crystallographic studies were undertaken to elucidate the inhibitory mechanism of captopril ster...
DNA cleavage and antitumoral activity of zinc(II) and iron(III) complexes with a new phenol-based ligand containing uncoordinated thioether moieties
Cancer is characterized by non-normal cell differentiation in or on a part of the body, leading to uncontrolled growth, me...
NMR insights into the behavior of bis-His motifs toward copper ions: A study using mono-N-methylated histidines
The bis-histidine (bis-His) motif is an apparently simple system consisting of two adjacent histidine residues. Despite it...
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