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NK cell adaptation in the tumor microenvironment: Insights for NK cell-based immunotherapy
The discovery of NK cells in 1975 unveiled a lymphocyte population capable of lysing malignant cells without prior sensiti...
Arteriolar angiogenesis: implications in anti-angiogenic immunotherapy for pancreatic cancers
Angiogenesis, described as a biological process from which new blood vessels develop from pre-existent ones, is closely as...
Pancreatic cancer exosomes: Their role in drug resistance and immunomodulation
Pancreatic ductal adenocarcinoma (PDAC) is a truly lethal malignancy worldwide. This indisposed prognosis of PDAC is a dir...
Role of cytokine-based immunotherapy approaches in gastrointestinal cancers
Gastrointestinal (GI) cancers, encompassing malignancies of the esophagus, stomach, pancreas, liver, colorectum, and other...
Targeting cytokines: Reshaping the pancreatic tumor microenvironment
Inflammation is a key part of tumor development, progression, and metastasis. Inflammation is a part of the host defensive...
Nanotechnology-based cytokine delivery strategies in gastrointestinal cancers
Although considerable progress has been made in diagnostic and therapeutic strategies, cancer continues to represent a maj...
SARS-CoV-2 innate immune recognition and implications for respiratory health
Dr. Yohannes Afework Mebratu: Biography Dr. Yohannes Afework Mebratu is a molecular biologist and an Assistant Professor i...
Erratum to “TLR-Based therapeutic strategies for Hepatocellular carcinoma” [Cytokine Growth Factor Rev. Volume 85 2025 Pages 179–189]
Volume 86, December 2025, Page 56Author links open overlay panelManoj Kumar Gupta a b, Ramakrishna Vadde aShow morePreviou...
Tightly bound T-cell clusters: A new class of hyper-effector tumor killers
Wenxue Ma, MD, PhD, is a specialist in Immuno-Oncology, physician scientist, and director of drug discovery at Sanford Ste...
The Cytokine–Skin Barrier Axis in Health and Disease
Maria Victoria Souto-Silva is a doctoral candidate at the Interdisciplinary Biosciences Laboratory, University of Brasília...
Post COVID-19 pandemic Inflammatory Insights into Cancer: Consequences for immunotherapy
Prof Anna-Mart Engelbrecht Anna-Mart Engelbrecht is a Professor of Physiological Sciences at Stellenbosch University, wher...
The IL-17 axis in gastric carcinogenesis: From inflammation to oncogenic transformation
Prof. Dr. Lei Huang (ORCiD: https://orcid.org/0000–0002–4225–9200), Principal Investigator leading the "Digestive Inflamma...
Biological macromolecule-driven therapeutics in rheumatoid arthritis: Integrating drug delivery, regenerative medicine, and orthopedic repair
Rheumatoid arthritis (RA) is a debilitating, chronic autoimmune disorder that impacts approximately 0.5–1 % of the global ...
Meteorin-like/Metrnl: A pleiotropic cytokine implicated in metabolic, inflammatory and malignant disorders
Professor Guangda Xiang(corresponding author), M.D. & Ph.D. He is a chief physician at department of endocrinology, ge...
Emerging involvement of CXCL13 in cancer development and progression
George S. Karagiannis, D.V.M, Ph.D., is an assistant professor in the Department of Microbiology and Immunology at the Alb...
Corrigendum to “Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy” [Cytokine Growth Factor Rev. 84 (2025) 59–73]
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Inflammation and Type 1 interferon signaling in pancreatic adenocarcinoma: Insights into inflammasome driven crosstalk and therapeutic advances
Spyridoula Katsarou I am a biomedical biologist with an academic background and hands-on research experience in molecular ...
Role of anti-tumorigenic cytokines in gastrointestinal cancers
Cancers of the gastrointestinal (GI) tract consistently track as some of the deadliest forms of malignancy worldwide [1]. ...
Combination therapy strategies targeting glypican-3 in hepatocellular carcinoma: A comprehensive review
Liver cancer remains a leading cause of cancer mortality worldwide. Global Cancer Statistics (GLOBOCAN) reported 865,269 n...
Interferons as therapeutic orchestrators of cancer stem cell plasticity and therapy response
Cancer stem cells (CSCs), also known as tumor-initiating cells, represent a critical population of tumor cells with self-r...
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights
Receptor tyrosine kinases (RTKs) are type-I membrane-bound proteins consisting of 58 members and can be further subdivided...
LC3B: A microtubule-associated protein influences disease progression and prognosis
Dr. Yanhong Zhou is professor at the Cancer Research Institute, Central South University. He obtained his PhD from Central...
Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases
Neutrophils, as essential component of the innate immune response, form a crucial part in the defence mechanisms through t...
Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders
Wenxue Ma, MD, PhD, is a distinguished specialist in Immuno-Oncology and serves as a physician-scientist at the University...
Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy
Dr Basta is a professor of Immunology at Queen’s University, Kingston, Canada. He obtained his PhD while working at the In...
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration
Mesenchymal tissue, including bone, fat, cartilage, muscle, and nerve, plays a critical role in the body's structural and ...
Forgetting COVID-19 – Introduction to the special issue
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets
Traumatic brain injury (TBI) is a leading cause of neurological disorders and significantly contributes to global morbidit...
The immunopathogenesis of a cytokine storm: The key mechanisms underlying severe COVID-19
Mitja Lainscak is Professor at Faculty of Medicine, University of Ljubljana, and does clinical practice and research at Di...
Interferon-I modulation and natural products: Unraveling mechanisms and therapeutic potential in severe COVID-19
Coronavirus disease 2019 (COVID-19) is a worldwide epidemic caused by severe acute respiratory syndrome coronavirus 2 (SAR...
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