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HUWE1 is involved in Sertoli cell polarity establishment by ubiquitination mediated degradation of WT1
HUWE1 is involved in Sertoli cell polarity establishment by ubiquitination mediated degradation of WT1
HUWE1, a member of HECT E3 ubiquitin ligase family, is implicated in a variety of cellular processes. Recent studies find ...
Cell division cycle protein 42-driven activation of the MKK3/6-p38 signaling pathway participates in cardiac remodeling in mice
Cell division cycle protein 42-driven activation of the MKK3/6-p38 signaling pathway participates in cardiac remodeling in mice
Cell division cycle protein 42 (Cdc42) is a member of the Rho GTPase subfamily that serves as a signal mediating factor in...
Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation
Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation
Sorafenib, a multikinase inhibitor targeting cell growth and angiogenesis, was approved for advanced unresectable hepatoce...
Organoids as powerful models of endometrium epithelium in transcriptomic, cellular and functional mimicry
Organoids as powerful models of endometrium epithelium in transcriptomic, cellular and functional mimicry
Organoids have emerged as revolutionary biomimetic systems that offer a physiologically relevant in vitro model to study t...
Natriuretic peptides as novel regulators of dendritic cells-mediated inflammation
Natriuretic peptides as novel regulators of dendritic cells-mediated inflammation
Natriuretic Peptides (NPs), including atrial (ANP) and brain (BNP) types, exert pleiotropic effects in regulating immune r...
Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer
Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer
Breast cancer (BC) is the most prevalent and highly heterogeneous malignancy affecting females worldwide, and its developm...
Ferroptosis in cancer: revealing the multifaceted functions of mitochondria
Ferroptosis in cancer: revealing the multifaceted functions of mitochondria
Ferroptosis is a programmed cell death characterized by iron-dependent lipid peroxidation, which is regulated by various c...
LRRK2 kinase modulates glucose-stimulated insulin secretion via RAB8 phosphorylation and ciliogenesis
LRRK2 kinase modulates glucose-stimulated insulin secretion via RAB8 phosphorylation and ciliogenesis
Leucine-rich repeat kinase 2 (LRRK2) encodes a multidomain protein whose mutations have been identified as genetic risk fa...
Ferroptosis and gut microbiota: A new horizon in alcohol-associated liver disease management
Ferroptosis and gut microbiota: A new horizon in alcohol-associated liver disease management
Alcohol-associated liver disease (ALD) is one of the most common chronic liver diseases worldwide, contributing significan...
Macrophage migration inhibitory factor mediates joint capsule fibrosis via facilitating phospholipid metabolite PGE2 production in fibroblasts
Macrophage migration inhibitory factor mediates joint capsule fibrosis via facilitating phospholipid metabolite PGE2 production in fibroblasts
Joint capsule persistent inflammation and subsequent fibrosis lead to post-traumatic joint contracture (PTJC). Fibroblasts...
From IP3RPEP6 Inhibition of IP receptor channels to insights: do channel subunits collaborate or cooperate?
From IP3RPEP6 Inhibition of IP receptor channels to insights: do channel subunits collaborate or cooperate?
Inositol 1,4,5-trisphosphate (IP3) receptor channels are intracellular ion channels activated by IP3 and provoking Ca2+ re...
CXCL12/CXCR4 modulates macrophage efferocytosis to induce glomerular crescent formation and fibrosis via ELMO1/DOCK180/RAC1 signaling in ANCA-associated glomerulonephritis
CXCL12/CXCR4 modulates macrophage efferocytosis to induce glomerular crescent formation and fibrosis via ELMO1/DOCK180/RAC1 signaling in ANCA-associated glomerulonephritis
ANCA-associated glomerulonephritis (AAGN) is a leading cause of uremia in children, driven by macrophages (Mφs) that ...
Pleckstrin-2 promotes the progression of colorectal cancer via YTHDF2-mediated TYMS mRNA stability
Pleckstrin-2 promotes the progression of colorectal cancer via YTHDF2-mediated TYMS mRNA stability
High expression of nucleotide synthetic enzyme thymidylate synthase (TYMS) is responsible for the resistance to fluorourac...
Ceramide and the membrane-fusion activity of LC3/GABARAP autophagy proteins
Ceramide and the membrane-fusion activity of LC3/GABARAP autophagy proteins
Macroautophagy is a cellular degradation process characterized by the formation of the double-membrane structure termed au...
Transcriptome remodelling and changes in growth and cardiometabolic phenotype result following knockdown in the early life of the zebrafish
Transcriptome remodelling and changes in growth and cardiometabolic phenotype result following knockdown in the early life of the zebrafish
Embryonic growth trajectory is a risk factor for chronic metabolic and cardiovascular disorders. Grb10 is a negative regul...
Fibroblasts activated by miRs-185-5p, miR-652-5p, and miR-1246 shape the tumor microenvironment in triple-negative breast cancer via PATZ1 downregulation
Fibroblasts activated by miRs-185-5p, miR-652-5p, and miR-1246 shape the tumor microenvironment in triple-negative breast cancer via PATZ1 downregulation
The intricate interplay between epithelial and fibroblast cells within the tumor microenvironment plays a crucial role in ...
MyD88 polymerization and association to cellular membranes in a yeast heterologous model
MyD88 polymerization and association to cellular membranes in a yeast heterologous model
MyD88 is a key mediator of Toll-like receptor (TLR) signaling, orchestrating the innate immune response upon stimulation b...
The oily nucleus– role of phospholipids in genome biology: membrane-directed roles and signaling in the nucleoplasm
The oily nucleus– role of phospholipids in genome biology: membrane-directed roles and signaling in the nucleoplasm
Phospholipids, widely known for their structural role in cellular membranes, are now also recognized to play pivotal roles...
Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma
Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma
OC2 knockout promotes apoptosis in HCC cells. OC2 knockout significantly inhibits tumor growth. OC2 promotes SKP2 transcri...
FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases
FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases
The development of antiviral strategies is a key task of biomedical research, but broad-spectrum virus inhibitors are scar...
Heterogeneous neutrophils in lung transplantation and proteolytic CXCL8 activation in COVID-19, influenza and lung transplant patient lungs
Heterogeneous neutrophils in lung transplantation and proteolytic CXCL8 activation in COVID-19, influenza and lung transplant patient lungs
Elevated neutrophil counts in broncho-alveolar lavage (BAL) fluids of lung transplant (LTx) patients with chronic lung all...
Potential compensatory mechanisms preserving cardiac function in myotubular myopathy
Potential compensatory mechanisms preserving cardiac function in myotubular myopathy
X-Linked myotubular myopathy (XLMTM) is characterized by severe skeletal muscle weakness and reduced life expectancy. The ...
Shared and distinct changes in the molecular cargo of extracellular vesicles in different neurodegenerative diseases
Shared and distinct changes in the molecular cargo of extracellular vesicles in different neurodegenerative diseases
Neurodegenerative disorders such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson̵...
Altered ACE2 and interferon landscape in the COVID-19 microenvironment correlate with the anti-PD-1 response in solid tumors
Altered ACE2 and interferon landscape in the COVID-19 microenvironment correlate with the anti-PD-1 response in solid tumors
Angiotensensin-converting enzyme-2 (ACE2) is a receptor for SARS-CoV-2, allowing the virus to enter cells. Although tumor ...
MTSS1: beyond the integration of actin and membrane dynamics
MTSS1: beyond the integration of actin and membrane dynamics
MTSS1 is a ubiquitously expressed intracellular protein known mainly for its involvement in basic cellular processes, such...
The glycogene alterations and potential effects in esophageal squamous cell carcinoma
The glycogene alterations and potential effects in esophageal squamous cell carcinoma
Aberrant glycosylation is one of the hallmarks of cancer. The profile of glycoprotein expression caused by abnormal glycos...
Epigenetic regulation of mitochondrial fission and cardiac fibrosis via sFRP3 promoter methylation
Epigenetic regulation of mitochondrial fission and cardiac fibrosis via sFRP3 promoter methylation
In the process of cardiac fibrosis, the balance between the Wnt/β-catenin signalling pathway and Wnt inhibitory facto...
Cross-regulation of RNA methylation modifications and R-loops: from molecular mechanisms to clinical implications
Cross-regulation of RNA methylation modifications and R-loops: from molecular mechanisms to clinical implications
R-loops, RNA–DNA hybrid structures, are integral to key cellular processes such as transcriptional regulation, DNA r...
Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation
Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation
Obesity is characterized by chronic low-grade inflammation, which is driven by macrophage infiltration in adipose tissue a...
Mfsd7b facilitates choline transport and missense mutations affect choline transport function
Mfsd7b facilitates choline transport and missense mutations affect choline transport function
MFSD7b belongs to the Major Facilitator Superfamily of transporters that transport small molecules. Two isoforms of MFSD7b...
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