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Conditional deletion of mTOR discloses its essential role in early B‐cell development
Conditional deletion of mTOR discloses its essential role in early B‐cell development
Abstract Mechanistic target of rapamycin (mTOR) is a serine-threonine kinase and central regulator of cell growth, differe...
Pharmacologic inhibition of ataxia telangiectasia and Rad3‐related (ATR) in the treatment of head and neck squamous cell carcinoma
Pharmacologic inhibition of ataxia telangiectasia and Rad3‐related (ATR) in the treatment of head and neck squamous cell carcinoma
Abstract Head and neck squamous cell carcinoma (HNSCC) poses significant treatment challenges, with high recurrence rates ...
Metabolic response to radiation therapy in cancer
Metabolic response to radiation therapy in cancer
Abstract Tumor metabolism has emerged as a hallmark of cancer and is involved in carcinogenesis and tumor growth. Reprogra...
The FoxQ1 transcription factor is a novel regulator of electron transport chain complex I subunits in human breast cancer cells
The FoxQ1 transcription factor is a novel regulator of electron transport chain complex I subunits in human breast cancer cells
Abstract The FoxQ1 is an oncogenic transcription factor that is overexpressed in basal-like and luminal-type human breast ...
Role of solute carrier transporters SLC25A17 and SLC27A6 in acquired resistance to enzalutamide in castration‐resistant prostate cancer
Role of solute carrier transporters SLC25A17 and SLC27A6 in acquired resistance to enzalutamide in castration‐resistant prostate cancer
Abstract Enzalutamide (XTANDI®), an antiandrogen, is used for the treatment of advanced-stage prostate cancer. Approx...
Tumor‐derived exosomes: Key players in non‐small cell lung cancer metastasis and their implication for targeted therapy
Tumor‐derived exosomes: Key players in non‐small cell lung cancer metastasis and their implication for targeted therapy
Abstract Exosomes represent extracellular vesicles of endocytic origin ranging from 30 to 100 nm that are released ...
LINC02381 aggravates breast cancer through the miR‐1271‐5p/FN1 axis to activate PI3K/AKT pathway
LINC02381 aggravates breast cancer through the miR‐1271‐5p/FN1 axis to activate PI3K/AKT pathway
Abstract Emerging investigations have demonstrated that lncRNAs are key crucial modulators in cancer. In this study, we in...
Issue Information ‐ Ed Board
Issue Information ‐ Ed Board
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Neoadjuvant endocrine therapy expands stromal populations that predict poor prognosis in estrogen receptor‐positive breast cancer
Neoadjuvant endocrine therapy expands stromal populations that predict poor prognosis in estrogen receptor‐positive breast cancer
Abstract The tumor microenvironment (TME) is an important modulator of response and resistance to endocrine therapy in est...
NUAK family kinase 2 is a novel therapeutic target for prostate cancer
NUAK family kinase 2 is a novel therapeutic target for prostate cancer
Abstract Current advancements in prostate cancer (PC) therapies have been successful in slowing PC progression and increas...
Setting up clinical trials for success: Applying preclinical advances in combined TGFβ/PD‐L1 inhibition to ongoing clinical studies
Setting up clinical trials for success: Applying preclinical advances in combined TGFβ/PD‐L1 inhibition to ongoing clinical studies
Abstract Combined TGFβ/PD-L1 inhibition is currently undergoing clinical trials in multiple cancer types. The early ...
Autophagy awakens—the myriad roles of autophagy in head and neck cancer development and therapeutic response
Autophagy awakens—the myriad roles of autophagy in head and neck cancer development and therapeutic response
Abstract Autophagy is an evolutionarily conserved cell survival mechanism that degrades damaged proteins and organelles to...
MicroRNA‐519d‐3p antagonizes osteosarcoma resistance against cisplatin by targeting PD‐L1
MicroRNA‐519d‐3p antagonizes osteosarcoma resistance against cisplatin by targeting PD‐L1
Abstract Accumulating evidence indicates that a ligand of programmed cell death receptor-1 (PD-L1) participates in the pro...
Cover Image, Volume 60, Issue 12
Cover Image, Volume 60, Issue 12
The cover image is based on the Research Article RAS induced senescence of skin keratinocytes is mediated through Rho-asso...
Proanthocyanidins mitigate bile acid‐induced changes in GSTT2 levels in a panel of racially diverse patient‐derived primary esophageal cell cultures
Proanthocyanidins mitigate bile acid‐induced changes in GSTT2 levels in a panel of racially diverse patient‐derived primary esophageal cell cultures
Abstract Persistent and symptomatic reflux of gastric and duodenal contents, known as gastroesophageal reflux disease (GER...
Colorectal cancer risk susceptibility loci in a Swedish population
Colorectal cancer risk susceptibility loci in a Swedish population
Abstract To search for colorectal cancer (CRC) risk loci, Swedish samples were used for a genome-wide haplotype analysis. ...
Triterpenoid ursolic acid drives metabolic rewiring and epigenetic reprogramming in treatment/prevention of human prostate cancer
Triterpenoid ursolic acid drives metabolic rewiring and epigenetic reprogramming in treatment/prevention of human prostate cancer
Abstract Ursolic acid (UA) is a triterpenoid phytochemical with a strong anticancer effect. The metabolic rewiring, epigen...
Transcriptional repression of E‐cadherin in nickel‐exposed lung epithelial cells mediated by loss of Sp1 binding at the promoter
Transcriptional repression of E‐cadherin in nickel‐exposed lung epithelial cells mediated by loss of Sp1 binding at the promoter
Abstract E-cadherin plays a central role in the stability of epithelial tissues by facilitating cell-cell adhesion. Loss o...
MiR‐15a‐3p regulates ferroptosis via targeting glutathione peroxidase GPX4 in colorectal cancer
MiR‐15a‐3p regulates ferroptosis via targeting glutathione peroxidase GPX4 in colorectal cancer
Abstract Colorectal cancer (CRC) is the second most common cancer-related deaths throughout the world. Ferroptosis is a re...
Association of tumor mutational burden with genomic alterations in Chinese urothelial carcinoma
Association of tumor mutational burden with genomic alterations in Chinese urothelial carcinoma
Abstract The tumor mutational burden (TMB) calculated by whole-exome sequencing (WES) is a promising biomarker for the res...
PARP5B is required for nonhomologous end joining during tumorigenesis in vivo
PARP5B is required for nonhomologous end joining during tumorigenesis in vivo
Abstract Poly(ADP-ribose) polymerases (PARP) act as DNA damage sensors that produce poly(ADP-ribose) (PAR) chains at doubl...
Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells
Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells
Abstract Paraspeckles compound 1 (PSPC1) is a multifunctional protein that plays an important role in cancer cells, where ...
Cover Image, Volume 60, Issue 11
Cover Image, Volume 60, Issue 11
The cover image is based on the Research Article A potential signaling axis between RON kinase receptor and hypoxia-induci...
Low expression of lncRNA SBF2‐AS1 regulates the miR‐302b‐3p/TGFBR2 axis, promoting metastasis in laryngeal cancer
Low expression of lncRNA SBF2‐AS1 regulates the miR‐302b‐3p/TGFBR2 axis, promoting metastasis in laryngeal cancer
Abstract The 5-year survival rate of laryngeal cancer continues to decline, and the laryngeal particularity of the anatomy...
Effects of radiation on tumor vasculature
Effects of radiation on tumor vasculature
Abstract Radiation has been utilized as a direct cytotoxic tumorcidal modality, however, the effect of radiation on tumor ...
Prognostic signatures and potential pathogenesis of eRNAs‐related genes in colon adenocarcinoma
Prognostic signatures and potential pathogenesis of eRNAs‐related genes in colon adenocarcinoma
Abstract Enhancer RNAs (eRNAs) are a subclass of long noncoding RNAs (lncRNAs) that have a wide effect in human tumors. Ho...
Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity
Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity
Abstract Type 2 transglutaminase (TG2) functions as an important cancer cell survival protein in a range of cancers includ...
Rapalogs induce non‐apoptotic, autophagy‐dependent cell death in HPV‐negative TP53 mutant head and neck squamous cell carcinoma
Rapalogs induce non‐apoptotic, autophagy‐dependent cell death in HPV‐negative TP53 mutant head and neck squamous cell carcinoma
Abstract TP53 is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSCC). Patients with HPV-nega...
Preoperative plasma level of endoglin as a predictor for disease outcomes after radical cystectomy for nonmetastatic urothelial carcinoma of the bladder
Preoperative plasma level of endoglin as a predictor for disease outcomes after radical cystectomy for nonmetastatic urothelial carcinoma of the bladder
Abstract Elevated preoperative plasma level of endoglin has been associated with worse oncologic outcomes in various malig...
Amateur antigen‐presenting cells in the tumor microenvironment
Amateur antigen‐presenting cells in the tumor microenvironment
Abstract Presentation of tumor antigens is a critical step in producing a robust antitumor immune response. Classically tu...
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