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Ferroptosis modulation by suppresses sodium iodate–driven age-related macular degeneration
Ferroptosis modulation by suppresses sodium iodate–driven age-related macular degeneration
Oxidative stress is a central driver of retinal pigment epithelium (RPE) degeneration and a defining pathological feature ...
Ubiquilin 1 Inhibits intracellular proliferation of through Xenophagy
Ubiquilin 1 Inhibits intracellular proliferation of through Xenophagy
Salmonella enterica serovar Typhimurium is a gram-negative bacterium that infects intestinal cells, causing gastroenteriti...
Transcriptomic analysis of zonula occludens-1 (ZO-1) knockout in ovarian cancer cell lines
Transcriptomic analysis of zonula occludens-1 (ZO-1) knockout in ovarian cancer cell lines
Zonula occludens-1 (ZO-1) is a crucial tight junction protein that regulates intercellular permeability and adhesion, ther...
Exploring Cyclo (-Gly-Pro) for inflammation modulation in atopic dermatitis: a study on streptococcal postbiotics
Exploring Cyclo (-Gly-Pro) for inflammation modulation in atopic dermatitis: a study on streptococcal postbiotics
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intense itching and eczematous lesions, sig...
Genome-wide identification of the gene family in reveals distinct roles of two genes in peach-like aroma formation
Genome-wide identification of the gene family in reveals distinct roles of two genes in peach-like aroma formation
Fatty acid desaturases (FADs) play crucial roles in plant growth and development. Fragaria nilgerrensis Schlecht., a wild ...
Anticancer activity of himantormione B: a new depsidone from the Antarctic lichen , in colorectal cancer
Anticancer activity of himantormione B: a new depsidone from the Antarctic lichen , in colorectal cancer
Recent studies have highlighted the pharmaceutical potential of lichen extracts, particularly with respect to their antica...
CDK9 inhibition triggers MT2A-dependent apoptosis in HCC cells
CDK9 inhibition triggers MT2A-dependent apoptosis in HCC cells
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. While cyclin-dependent kinase 9 (...
Parametric hypothesis testing for pathway based hierarchical structural component models
Parametric hypothesis testing for pathway based hierarchical structural component models
Hierarchical Structural Component Model (HisCoM) are statistical tools developed for pathway analysis that enable the simu...
Roles of Lcn2 and neuroinflammation in a scopolamine-induced cognitive impairment animal model: implication of the NLRP3 inflammasome pathway
Roles of Lcn2 and neuroinflammation in a scopolamine-induced cognitive impairment animal model: implication of the NLRP3 inflammasome pathway
With increasing life expectancy in modern society, the prevalence of age-related diseases has risen, among which cognitive...
SEMA4A promotes acute myeloid leukemia progression through inhibiting apoptosis
SEMA4A promotes acute myeloid leukemia progression through inhibiting apoptosis
Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy. Currently, targeted therapy represents a trans...
Single-cell transcriptomics and machine learning identify RNF144B and C5AR1 as immune-related molecular signatures and therapeutic targets in myocardial infarction
Single-cell transcriptomics and machine learning identify RNF144B and C5AR1 as immune-related molecular signatures and therapeutic targets in myocardial infarction
Myocardial infarction (MI) is a life-threatening cardiovascular disease characterized by high morbidity and mortality. Alt...
5-Aminoimidazole-4-carboxamide riboside, an AMPK activator, enhances TRAIL-mediated apoptosis in human bladder cancer cells in a p38 MAPK-dependent manner
5-Aminoimidazole-4-carboxamide riboside, an AMPK activator, enhances TRAIL-mediated apoptosis in human bladder cancer cells in a p38 MAPK-dependent manner
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in cancer cells; however, ma...
Transcriptomic analysis reveals functional compartmentalization of the digestive tract in
Transcriptomic analysis reveals functional compartmentalization of the digestive tract in
The digestive system of marine annelids is essential for nutrient metabolism, luminal transport, and environmental interac...
Platform-dependent performance of P2A and IRES linkers in multicistronic gene expression
Platform-dependent performance of P2A and IRES linkers in multicistronic gene expression
Efficient co-expression of multiple genes within individual cells is essential for advances in biotechnology and clinical ...
Selection of heat stress-tolerant cultivars from radish and analysis of gene expression under high-temperature
Selection of heat stress-tolerant cultivars from radish and analysis of gene expression under high-temperature
Global warming has significant impacts on crop growth and agricultural stability, particularly for temperature-sensitive c...
Histone mark remodeling in cancer: an enhancer-centered perspective
Histone mark remodeling in cancer: an enhancer-centered perspective
Epigenetic deregulation is a defining feature of cancer, and histone modification remodeling plays a central role in resha...
ZNF468 stabilization by RNF4 enhances apoptosis resistance and carboplatin resistance in breast cancer via transcription activation of XIAP
ZNF468 stabilization by RNF4 enhances apoptosis resistance and carboplatin resistance in breast cancer via transcription activation of XIAP
Carboplatin is a commonly utilized chemotherapy agent for breast cancer treatment, yet resistance to this drug remains a s...
Anti-inflammatory activity and antioxidant capacity of (Thunb.) sweet extract in LPS-stimulated macrophages
Anti-inflammatory activity and antioxidant capacity of (Thunb.) sweet extract in LPS-stimulated macrophages
Clerodendrum japonicum (Thunb.) Sweet is a medicinal plant native to East Asia, including Korea, Japan, and China. Its lea...
DNA purity over yield: optimizing extraction and PCR in degraded Asian elephant () fecal samples
DNA purity over yield: optimizing extraction and PCR in degraded Asian elephant () fecal samples
Non-invasive genetic monitoring is essential for conserving the endangered Asian elephant (Elephas maximus). However, feca...
Integrated transcriptomic analysis reveals KRAS-associated gene activation and epigenetic regulation in mutant IDH1 glioma
Integrated transcriptomic analysis reveals KRAS-associated gene activation and epigenetic regulation in mutant IDH1 glioma
Mutations in isocitrate dehydrogenase 1 (IDH1) are hallmark features of diffuse gliomas and drive extensive metabolic and ...
Targeting the miR-325-3p/GSTP1 axis overcomes paclitaxel resistance in triple-negative breast cancer by inducing ferroptosis
Targeting the miR-325-3p/GSTP1 axis overcomes paclitaxel resistance in triple-negative breast cancer by inducing ferroptosis
Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options, and paclitaxel resistance re...
Metabolic profiling and genetic tool development in the mucosal bacterium
Metabolic profiling and genetic tool development in the mucosal bacterium
Selenomonas sputigena is an anaerobic mucosa-associated bacterium with dual roles in human health—acting as a pathob...
The role of RANBP1 in regulating MiRNA expression and apoptosis in breast cancer cells
The role of RANBP1 in regulating MiRNA expression and apoptosis in breast cancer cells
Breast cancer poses a huge health threat in China. Emerging evidence has indicated that RANBP1 is associated with poor pro...
Multi-omics integration reveals CYTL1 and H6PD as key regulators of tumor metabolism in mesothelioma
Multi-omics integration reveals CYTL1 and H6PD as key regulators of tumor metabolism in mesothelioma
Mesothelioma is a rare and aggressive cancer with limited therapeutic options and poor prognosis. Despite advancements in ...
ElF5B as a prognostic biomarker and its correlation with infiltrating immune cells in liver cancer
ElF5B as a prognostic biomarker and its correlation with infiltrating immune cells in liver cancer
The clinical behavior and molecular mechanisms of hepatocellular carcinoma (HCC) are intricate and highly variable, posing...
PRDM14 promoted NSCLC cell proliferation, migration and invasion via modulating H3K27me3-mediated PEBP1/Raf-1/MEK/ERK MAPK signaling
PRDM14 promoted NSCLC cell proliferation, migration and invasion via modulating H3K27me3-mediated PEBP1/Raf-1/MEK/ERK MAPK signaling
Our previous research revealed that PRDI-BF1 and RIZ homology domain containing protein 14 (PRDM14) accelerated human non-...
Sex-specific programming of the gastric and duodenal mitochondrial biogenesis by early-life stress
Sex-specific programming of the gastric and duodenal mitochondrial biogenesis by early-life stress
Early-life stress (ELS) is a significant risk factor for the development of numerous metabolic and physiological disorders...
In-silico matching of SARS-CoV-2 genes and oligonucleotides using the Simple Oligo Matching Tool
In-silico matching of SARS-CoV-2 genes and oligonucleotides using the Simple Oligo Matching Tool
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a global pandemic, necessitating accurate diagnost...
Decoding splicing complexity: integrated genomic analysis reveals two novel pathogenic variants in Chinese dystrophinopathy pedigrees
Decoding splicing complexity: integrated genomic analysis reveals two novel pathogenic variants in Chinese dystrophinopathy pedigrees
Dystrophinopathy is severe X-linked recessive muscle disease caused by mutations in DMD gene. There is an increasing numbe...
Deep learning-driven whole-slide image analysis predicts chemo-resistance and motility subtypes in muscle-invasive bladder cancer
Deep learning-driven whole-slide image analysis predicts chemo-resistance and motility subtypes in muscle-invasive bladder cancer
Muscle-invasive bladder cancer (MIBC) is a clinically aggressive and heterogeneous disease with variable treatment respons...
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