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Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination
Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination
Pyroptosis, which rapidly releases cellular contents through pyroptotic pores, is an ideal method for inducing in situ can...
Nanoparticles-based phototherapy systems: molecular mechanisms and clinical applications
Nanoparticles-based phototherapy systems: molecular mechanisms and clinical applications
Nanoparticle-based phototherapy represents a paradigm shift in precision medicine, harnessing light-activated mechanisms t...
A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms
A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms
COVID-19 resulting from SARS-CoV-2 infection has presented significant challenges to global health over the past several y...
M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation
M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation
Cardiac ischemia‒reperfusion (I/R) injury is a leading cause of disability and mortality worldwide, but the underlyi...
Chemo-photothermal synergy ignites antitumor immunity via ferroptosis
Chemo-photothermal synergy ignites antitumor immunity via ferroptosis
Docetaxel (Doc), a widely used chemotherapeutic agent, was limited by suboptimal therapeutic efficacy and dose-limiting sy...
DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling
DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling
Primary resistance to chimeric antigen receptor (CAR) T-cell therapies has limited their widespread application. Our prior...
Cleaved SREBP-2 C-terminal fragment noncanonically drives interleukin-1 receptor-associated kinase 1-dependent apoptosis
Cleaved SREBP-2 C-terminal fragment noncanonically drives interleukin-1 receptor-associated kinase 1-dependent apoptosis
Sterol regulatory element-binding protein 2 (SREBP-2) is a central regulator...
Spi-1 proto-oncogene regulates mRNA hypertranscription and malignant progression in head and neck cancer
Spi-1 proto-oncogene regulates mRNA hypertranscription and malignant progression in head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent and lethal cancers worldwide. Despite multimoda...
Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder
Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder
Post-traumatic stress disorder (PTSD) remains a debilitating psychiatric condition with limited pharmacological treatment ...
Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions
Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions
Nuclear receptors (NRs) are a large family of ligand-dependent transcription factors that regulate the expression of a wid...
Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights
Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights
Decompensated liver cirrhosis (DLC) is characterized by severe liver dysfunction and immune dysregulation, posing signific...
Dynamics of neutralizing antibodies against COVID-19 Omicron subvariants following breakthrough infection in southwest China between December 2022 and April 2024
Dynamics of neutralizing antibodies against COVID-19 Omicron subvariants following breakthrough infection in southwest China between December 2022 and April 2024
From December 2022 to January 2023, the SARS-CoV-2 Omicron BA.5/BF.7 variant significantly impacted mainland China. While ...
Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches
Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches
Immune evasion represents a significant challenge in oncology. It allows tumors to evade immune surveillance and destructi...
Impact of allogeneic dental pulp stem cell injection on tissue regeneration in periodontitis: a multicenter randomized clinical trial
Impact of allogeneic dental pulp stem cell injection on tissue regeneration in periodontitis: a multicenter randomized clinical trial
Periodontitis causes the destruction of tooth-supporting tissues, and current therapies for periodontal regeneration are i...
Targeting AKR1B1 inhibits metabolic reprogramming to reverse systemic therapy resistance in hepatocellular carcinoma
Targeting AKR1B1 inhibits metabolic reprogramming to reverse systemic therapy resistance in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, and resistance to systemic therapies remain...
Epigenetic regulation of cancer stemness
Epigenetic regulation of cancer stemness
Gene expression is finely controlled by the abundance and activation status of transcription factors and their regulators,...
Efficacy and safety of lenvatinib plus gefitinib in lenvatinib-resistant hepatocellular carcinomas: a prospective, single-arm exploratory trial
Efficacy and safety of lenvatinib plus gefitinib in lenvatinib-resistant hepatocellular carcinomas: a prospective, single-arm exploratory trial
Lenvatinib, a multi-kinase inhibitor, has been approved as first-line treatment for advanced hepatocellular carcinoma (HCC...
Anlotinib plus chemotherapy as a first-line treatment for gastrointestinal cancer patients with unresectable liver metastases: a multicohort, multicenter, exploratory trial
Anlotinib plus chemotherapy as a first-line treatment for gastrointestinal cancer patients with unresectable liver metastases: a multicohort, multicenter, exploratory trial
This multicohort phase II trial (ALTER-G-001; NCT05262335) aimed to assess the efficacy of first-line anlotinib plus chemo...
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Alternating modified CAPOX/CAPIRI plus bevacizumab in untreated unresectable metastatic colorectal cancer: a phase 2 trial
Alternating modified CAPOX/CAPIRI plus bevacizumab in untreated unresectable metastatic colorectal cancer: a phase 2 trial
Previous studies showed encouraging efficacy of alternating FOLFOX/FOLFIRI for metastatic colorectal cancer (mCRC). This p...
Correction: Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates
Correction: Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Bridge over troubled cells: bone marrow stromal cells transfer mitochondria to boost T cells
Bridge over troubled cells: bone marrow stromal cells transfer mitochondria to boost T cells
In an article published in Cell in September 2024, Baldwin and colleagues pr...
CD4 T cell contact drives macrophage cell cycle G0-G1 transition
CD4 T cell contact drives macrophage cell cycle G0-G1 transition
Macrophages are cells implicated in a diverse array of functions such as def...
Clinical and biomarker analyses of SHR-1701 combined with famitinib in patients with previously treated advanced biliary tract cancer or pancreatic ductal adenocarcinoma: a phase II trial
Clinical and biomarker analyses of SHR-1701 combined with famitinib in patients with previously treated advanced biliary tract cancer or pancreatic ductal adenocarcinoma: a phase II trial
Advanced biliary tract cancer (BTC) and pancreatic ductal adenocarcinoma (PDAC) have poor prognoses and limited treatment ...
Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
In a recent Science article, Wang and colleagues showed that the dipeptidyl peptidase 4 (DPP4) enzyme...
IgE-Mast cell mediated allergy: a sensor of food quality
IgE-Mast cell mediated allergy: a sensor of food quality
In two recent studies published in Nature, Florsheim et al. and Plum et al. reported that allergic-sp...
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, ...
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other cell death modes, p...
Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
In a recent article published in Cancer Discovery, Guirguis et al. demonstrated that enzymatic inhibi...
Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer’s disease
Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer’s disease
A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to...
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