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Extracellular vesicle-mediated transcellular mitophagy as a modulatory target for moderate hyperoxia-induced alveolar developmental arrest in bronchopulmonary dysplasia
The authors declare that all data supporting the findings of this study are available within the paper and its supplementa...
Aldh3a1-mediated detoxification of reactive aldehydes contributes to distinct muscle responses to amyotrophic lateral sclerosis progression
Amyotrophic Lateral Sclerosis (ALS) is a devastating neuromuscular disorder characterized by progressive motor neuron deat...
The role of NPY in liver transplantation from extended-criteria donors
Donor shortage has increased liver transplantation (LT) waiting lists. The use of livers grafts from extended criteria don...
Brain lipidomics identifies mitochondrial redox dysfunction and metabolic trade-offs associated with Parkinson's disease-like pathology induced by Nanoplastics exposure
Over recent decades, the relentless accumulation of plastic waste in terrestrial and aquatic environments has emerged as a...
Ferroptosis mediates retinal damage caused by the combined effects of sleep deprivation and light damage
Volume 249, June 2026, Pages 548-562Author links open overlay panel, , , , Highlights•Established a dual-stressor mouse mo...
A fluorescent hydrogen sulfide donor featuring hydroxyl radical responsiveness promotes diabetic wound healing through the regulation of macrophage polarization
Macrophages, as a critical component of the immune system, play a central role in maintaining tissue homeostasis, defendin...
Bufotenidine attenuates astrocyte ferroptosis in depressive-like behaviors through targeting GluA1 to reduce neuronal lipid synthesis
Depression is a common mental disorder characterized by persistent low mood, anhedonia, and cognitive impairment, seriousl...
Mechanisms controlling transcription in hypoxia; an unexpected role of NF-κB
Reduced oxygen availability or increased demand for oxygen in cells leads to a stress condition known as hypoxia. Hypoxia ...
Oxysterols in the defense against viral infections in humans
Within the family of cholesterol oxidative derivatives known as oxysterols, several members, particularly those synthesize...
PANoptosis in Alzheimer's disease: The expanding landscape of programmed cell death mechanisms and therapeutic interventions
Alzheimer's disease (AD) is a progressive neurological disease that gradually impairs cognitive function and ultimately re...
DECR1 deficiency activates a lipid peroxidation–mitocytosis–mitochondrial dysfunction axis in trophoblasts to promote preeclampsia
Preeclampsia (PE) is a pregnancy disorder characterized by placental maladaptation and maternal hypertension, with oxidati...
GPX3 activates autophagy to protect cochlear spiral ganglion neurons from injury in age-related hearing loss
Age-related hearing loss (ARHL), also referred to as presbycusis, is the leading cause of disabling hearing impairment, wh...
ICAM-1 targeted extracellular vesicles loaded with HC-070 mitigate vascular oxidative stress and inflammation in obstructive sleep apnea hypopnea syndrome by inhibiting TRPC5
Obstructive sleep apnea–hypopnea syndrome (OSAHS) is a common sleep disorder marked by repeated episodes of complete or pa...
Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity
Humanin is a mitochondrial-derived peptide with cytoprotective properties, but how it has evolved in response to different...
Downregulation of TDP43 by atovaquone inhibits oxidative phosphorylation and enhances sensitivity of triple-negative breast cancer to EGFR-TKIs
Volume 250, July 2026, Pages 64-79Author links open overlay panel, , , , , , , , , , , Highlights•Revealed the molecular m...
Targeting the IRE1α/JNK-autophagy axis in microglia attenuates retinal neovascularization in oxygen-induced retinopathy
Volume 250, July 2026, Pages 99-115Author links open overlay panel, , , , , , Highlights•IRE1α/JNK signaling is activated ...
CAP1 deficiency protects podocytes in diabetic kidney disease by reducing mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial fission
The mitochondria-associated endoplasmic reticulum membrane (MAM) is crucial for mitochondrial homeostasis. Excessive mitoc...
Inhibition of endothelial ALOX12 mitigates cerebral ischemia–reperfusion injury by suppressing 12-HETE
Acute ischemic stroke (AIS) is a major cerebrovascular disorder caused by the abrupt interruption of cerebral blood flow, ...
SIRT1 activation restores PINK1-dependent mitophagy to reverse airway barrier dysfunction in Acinetobacter baumannii infection
Acinetobacter baumannii (A. baumannii) is one of the most common pathogens causing hospital-acquired infections. It exhibi...
Mitochondrial DNA alterations in mothers and offspring following in utero exposure to ionizing radiation
Approximately two billion years ago, the ancestor of eukaryotic cells established an endosymbiotic relationship with aerob...
Serum selenoprotein P concentrations and cardiovascular disease: results from a large, prospective cohort study of older German adults
Volume 239, November 2025, Pages 270-279Author links open overlay panel, , , , , , Highlights•Population-based study on se...
ALKBH5 regulates ACSL4 to sensitize erastin-induced ferroptosis via YTHDF2-dependent m6A modification in hypoxic pulmonary hypertension
Volume 239, November 2025, Pages 280-297Author links open overlay panel, , , , , , , Highlights•PASMCs under hypoxic condi...
Muscone inhibits ferroptosis for neuroprotection in a Parkinson's disease model
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder globally, impacting an estimated 6 millio...
Astragalin induces immunogenic cell death in liver cancer by targeting NQO2 to promote ROS-mediated endoplasmic reticulum stress pathway
Liver cancer is the sixth most common cancer worldwide and the third leading cause of cancer-related deaths [1]. According...
Soybean genistin-driven gut microbiota-derived butyrate synthesis activates the SIRT1 signaling pathway to ameliorate metabolic fatty liver
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a novel diagnostic criterion proposed by an international ...
MiRNA-122-5p promotes retinal ganglion cell oxidative damage by targeting DJ-1 in hyperglycemic retina
Diabetic retinopathy (DR), a progressive neurovascular disorder in diabetic retinas, manifests through interrelated pathol...
Porcine epidemic diarrhea virus induces PANoptosis in piglet intestinal cells via Z-RNA/ZBP1/ROS pathway-mediated oxidative stress activation
Porcine epidemic diarrhea (PED) is an intestinal infectious disease caused by the procine epidemic diarrhea virus (PEDV), ...
Dehydroascorbic acid impairs neurite growth through RIPK1-associated caspase activation
Normal neuronal structure and maintenance of neuritic processes is essential for cognitive activity and adequate motor coo...
Temporal dynamics of oxylipins and antioxidant metabolites in rainbow trout muscle are driven by diet type rather than methylmercury or selenomethionine supplementation
Tuna by-products in aquafeed pose challenges due to heavy metals like mercury (Hg), which has pro-oxidant effects. However...
Hyperactivation of the m6A demethylase FTO to down-regulate SLC7A11/xCT-mediated redox homeostasis and epigenetic remodeling in facial infiltrating lipomatosis
Facial infiltrating lipomatosis (FIL) is a rare congenital deformity caused by excessive accumulation of adipose tissue. T...
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