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From mechanisms to clinical applications: Advances in 40 Hz gamma oscillation modulation for the treatment of neurological disorders
Over the past decade, neural oscillations have emerged as a research focus in cognitive neuroscience and clinical neurosci...
Decoy oligodeoxynucleotides and peptides as a promising approach for managing myocardial infarction and stroke
Both the demographic change toward an older population and the fast pace of urbanization have contributed to the prevalenc...
An integrative genomic framework to identify remote ischemic preconditioning–responsive genes associated with stroke risk
Stroke remains a leading cause of morbidity and mortality globally (Feigin et al., 2025; Prust et al., 2024), yet effectiv...
Shift in motor-state equilibrium explains gait therapy effects of apomorphine in experimental Parkinsonism
Gait impairments remain a major therapeutic challenge in Parkinson's disease (PD). Apomorphine is gaining renewed clinical...
Plant-derived extracellular vesicles restore cellular energetics for peripheral nerve regeneration through glycolysis reprogramming
Peripheral nerve injury (PNI) is a common but complex traumatic disorder often resulting in sensory and motor dysfunction ...
Sulforaphane improved cognitive behavior in APP/PS1 mice via promoting structural and functional synaptic plasticity in the hippocampus
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by insidious onset and gradual cognitiv...
Effect of chronic intermittent hypoxia on apoptosis based on microbiome-based co-metabolomics
Chronic intermittent hypoxia (CIH), a core pathophysiological feature of obstructive sleep apnea (OSA), is closely associa...
Anti-NMDAR antibody exposure induces cognitive inflexibility and prefrontal GABAergic dysregulation in mice
Anti-N-methyl-d-aspartate-receptor (NMDAR) encephalitis is the most common type of autoimmune encephalitis that frequently...
Differential effects and underlying mechanisms of voluntary, forced, and combined exercise on ameliorating Alzheimer's disease pathophenotypes
Alzheimer's disease (AD), the most prevalent neurodegenerative dementia, is characterized by progressive deterioration of ...
Adolescent experiences remodel hippocampal glycerophospholipid metabolism associated with adult memory
Experiences critically shape brain development and cognitive trajectories across the lifespan. Environmental conditions du...
The potential of Bifidobacterium longum subsp. infantis in ameliorating traumatic brain injury-induced cognitive impairment in mice
TBI is regarded as a chronic disease that may affect multiple functional domains. Studies have shown that brain function i...
Rapamycin treatment reduces CD11c+ microglia and increases amyloid plaque load in 5xFAD mice
Alzheimer's disease (AD) accounts for up to 80% of dementia cases with 44 million people currently affected worldwide (GBD...
Rotational TBI causes neuronal stress and changes in the monoamine and galanin systems
Traumatic brain injury (TBI) is frequently followed by persistent affective symptoms. Dysregulation of monoaminergic and g...
IL-1β neutralization ameliorates cognitive deficits and tau pathology in a mouse model of Alzheimer's disease with hyperhomocysteinemia
Alzheimer's disease (AD) is the most common neurodegenerative disorder and the leading cause of dementia worldwide, accoun...
Investigating the behavioral impact of tropical almond (Terminalia catappa L.) consumption: Anxiolytic effects and memory preservation in aged rats
The global older adult population has grown significantly, accompanied by an increase in the incidence of anxiety disorder...
Naturally occurring antibodies against ASC are reduced in Alzheimer’s Disease and alleviate AD-type pathology in APP/PS1 mice
Alzheimer's Disease (AD) is the most common type of dementia in the elderly, which is characterized by progressive cogniti...
Mild concussion impairs extinction of avoidance and alters respective brain circuits in male rats
Volume 401, July 2026, 115734Author links open overlay panel, , , , , , Highlights•The influence of concussion to active a...
Neuroprotective effect of RMF in a mouse model of sporadic Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons ins...
Hippocampal astrocyte St6galnac5 silencing improves spatial memory and preserves synaptic integrity in an AD mouse model
The unprecedented extension in human life expectancy has precipitated a surge in age-associated neurodegenerative disorder...
Integrative genomics elucidates the evolutionary, temporal, and developmental origins of a hydrocephalus risk gene
Hydrocephalus (HC) is a heterogeneous neurodevelopmental disorder resulting from aberrant brain-cerebrospinal fluid (CSF) ...
Orexin A alleviates chronic cerebral hypoperfusion-induced neuroinflammation and cognitive dysfunction by inhibiting the NEK7/NLRP3 pathway
Vascular dementia (VaD) is the second most common form of dementia after Alzheimer's disease (AD) and is unique in that it...
The development but not the maintenance of phrenic and sympathetic long-term facilitation after acute intermittent hypoxia requires nucleus tractus solitarii H2O2
Cardiovascular and respiratory control systems undergo plastic changes in function that are critical to the maintenance of...
Overexpression of endothelial β4 integrin has no impact on blood-brain barrier integrity or the pathogenesis of experimental autoimmune encephalomyelitis
Multiple sclerosis (MS), the most common neurological disease affecting the young to middle-aged population, is a chronic ...
High fat diet and low dose-rotenone exposure exacerbate Parkinson's disease like pathology through gut-brain axis disruption
Neurodegeneration is a heterogeneous condition that affects the quality of life of millions worldwide. It results from a p...
Integrative multi-omics and machine learning identify CALR as a diagnostic and therapeutic target in aneurysmal subarachnoid hemorrhage
BackgroundAneurysmal subarachnoid hemorrhage (aSAH), caused by the rupture of intracranial aneurysms, is a devastating cer...
Persistent inflammation and white matter damage in the preterm brain: Insights from a novel ovine model of chronic inflammation
BackgroundPreterm brain injury involves persistent inflammation, making it a potential therapeutic target. Current large a...
Stereotactic infusion of rotenone into the SN induced a late-stage model of Parkinson's disease
Parkinson's disease (PD) is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra and the accumul...
Effects of centromedian thalamic deep brain stimulation on striatal glutamate and GABA in a rodent model of epilepsy
Deep brain stimulation of the centromedian nucleus of the thalamus (CM-DBS) has emerged as a potential treatment for patie...
miR-497-5p augments sevoflurane-induced neurotoxicity by facilitating ubiquitination-dependent degradation of NOTCH1 via targeting SMURF2
Sevoflurane, a widely utilized inhalation anesthetic, has raised concerns regarding its neurotoxic effects, particularly d...
Pyridoxal phosphate inhibits alpha-synuclein-induced ferroptosis by activating GOT1 to enhance the methionine salvage pathway in Parkinson's disease
Parkinson's disease (PD) is a prevalent neurodegenerative disorder marked by the selective death of dopaminergic neurons i...
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