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Clinical and genetic determinants of glioblastoma survival: a retrospective study
BackgroundThis study analyzed 57 patients with glioblastoma treated at the General University Hospital of Castellon, Spain...
Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation
CB1 and GPR55 receptors form heteromers in striatal neurons; however, the effects of these heteromers on GABA release at t...
Lactate and cognition: a dual modulator
Lactate, traditionally regarded as a byproduct of glycolysis, has emerged as a key metabolic substrate and signaling molec...
Notch signaling inhibition attenuates epileptogenesis and hippocampal damage without altering mossy fiber sprouting in adolescent rats post-status epilepticus
BackgroundNotch overactivation and aberrant neurogenesis following status epilepticus (SE) has been identified by our prev...
Integrating neural organoids and AI: increasing the risk of artificial consciousness or medical malpractice?
Neural organoids can be integrated with AI models in various formats, termed AI-NO systems. Neural organoids and AI are ea...
Modulation of apolipoprotein E receptor-2 by ApoE4, amyloid β-peptide, reelin, and secreted amyloid precursor protein: a common point of impact in Alzheimer’s disease pathogenesis
IntroductionApolipoprotein E (ApoE), reelin, and several other proteins bind ApoE-receptor 2 (apoER2), distinguished from ...
Mediterranean diet and gut microbiota: impact on memory and other cognitive functions: a systematic review
In recent years, there has been growing interest in the study of gut microbiota and its relationship with multiple disease...
Transcriptomic identification of CREB1 and FOXO1 activation in neuregulin-1-mediated neuroprotection after stroke
IntroductionNeuregulin-1 (NRG-1) is a growth factor that has been investigated for its neuroprotective properties followin...
Mentorship, memory, and honor: Rita Levi-Montalcini’s legacy and the role of academic recognition in promoting women in science
The contemporary vignette highlights how the mentorship model exemplified by Rita Levi-Montalcini continues to foster scie...
Retraction: Selected thiadiazine-thione derivatives attenuate neuroinflammation in chronic constriction injury induced neuropathy
A Retraction of the Original Research Article Selected thiadiazine-thione derivatives attenuate neuroinflammation in chron...
Glycine transport inhibitors for the treatment of chronic pain conditions: the time is ripe for clinical evaluation!
The treatment of chronic pain is -despite intensive research -still challenging, and the outcomes for patients are in many...
Polyclonal glycine receptor aAbs: a challenge for personalized epitope characterization
IntroductionPatients with glycine receptor (GlyR) aAbs suffer from various diseases, including stiff-person syndrome (SPS)...
TDP-43 related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review and narrative synthesis
Mislocalization and aggregation of the DNA/RNA binding protein, TDP-43, is seen in most cases of amyotrophic lateral scler...
Editorial: Neuroglycobiology
Neuroglycobiology sits at the intersection of neuroscience and glycobiology, focusing on how glycans and glycoconjugates s...
Integrated genetic analysis reveals synaptic m6A enrichment in high-risk autism genes
Autism Spectrum Disorder (ASD), a complex neurodevelopmental condition, is characterised by reduced social and emotional e...
CNP-induced cGMP signaling reduces growth cone stiffness and Ca2+ levels in embryonic DRG neurons
A cyclic guanosine monophosphate (cGMP) signaling pathway composed of the extracellular ligand C-type natriuretic peptide ...
Chronic pain, fatigue, and emotional distress in female FMR1 premutation carriers
IntroductionCarriers of the FMR1 gene premutation (PM) are at increased risk for Fragile X-associated PM Conditions (FXPAC...
Integrative genomic analysis identifies key target genes and candidate drugs for spinal stenosis
BackgroundSpinal stenosis is a common pathological condition characterized by the narrowing of the spinal canal, contribut...
Exploring the mechanism of Yin Huo decoction in PCPA-induced depression mice: a metabolomics and network pharmacology approach
IntroductionDepression is a prevalent neuropsychiatric disorder, and traditional Chinese medicine formulations such as Yin...
Abnormal lymphatic system function in patients with chronic neck and shoulder pain: neuroimaging evidence from DTI-ALPS
ObjectiveChronic neck and shoulder pain (CNSP) is frequently associated with structural and functional brain damage that p...
Differential timing of mitochondrial activation in rat dorsal striatum induced by procedural learning and swimming
1 Introduction Aversive learning experiences are associated with the activation of the hypothalamic-pituitary-adrenal axi...
Mitochondrial pathways of copper neurotoxicity: focus on mitochondrial dynamics and mitophagy
1 Introduction Copper (Cu) is an essential element involved in a plethora of metabolic processes through its structural,...
Transcorneal electrical stimulation restores DNA methylation changes in retinal degeneration
Introduction Retinal degeneration is a major cause of irreversible blindness. It is projected that the incidence of reti...
Calcium-sensor proteins but not bicarbonate ion activate retinal photoreceptor membrane guanylyl cyclase in photoreceptors
Introduction Vertebrate rods and cones respond to light by changing the permeability of cyclic nucleotide-gated cation c...
Development of KCC2 therapeutics to treat neurological disorders
Introduction The KCC2 transporter is the CNS neuron-specific Cl– extruder essential for the establishment and maintenance...
Chaperones vs. oxidative stress in the pathobiology of ischemic stroke
1 Introduction The global burden inflicted by ischemic stroke is dramatic: the annual number of new cases [7,630,803 in 2...
Excitatory neuron-prone prion propagation and excitatory neuronal loss in prion-infected mice
Introduction Prion diseases are fatal and intractable neurodegenerative disorders affecting both animals and humans, inc...
VNS paired with training enhances recognition memory: mechanistic insights from proteomic analysis of the hippocampal synapse
1 Introduction Recognition memory is a fundamental component of cognitive health, allowing us to learn and remember new ...
A sex-specific effect of M4 muscarinic cholinergic autoreceptor deletion on locomotor stimulation by cocaine and scopolamine
1 Introduction Acetylcholine regulates numerous critical functions within the basal ganglia by activating nicotinic and m...
Circulating miR-134 in mesial temporal lobe epilepsy: implications in hippocampal sclerosis development and drug resistance
1 Introduction Epilepsy is a chronic neurological disease that affects more than 50 million persons worldwide, 80% of wh...
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