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Gut transit and gut microbiome changes occur prior to the onset of motor impairment in a mouse model of Machado-Joseph disease
The 16S rRNA gene sequence data generated and analysed during the current study are available in the National Centre for B...
Single nucleus RNA sequencing unveils relationship between microglia and endothelial cells in mixed Alzheimer's disease and vascular pathology
Volume 216, November 2025, 107128Author links open overlay panel, , , , , , , , , , Highlights•Expression of receptors P2R...
Altered APP trafficking drives amyloidogenic processing in primary neurons from the AppNL-F knock-in mouse model of Alzheimer's disease
Volume 216, November 2025, 107129Author links open overlay panel, , , , , Highlights•Super-resolution microscopy truly res...
Comparison of neuron-derived extracellular vesicles miRNA profile between patients with behavioural variant frontotemporal dementia and primary psychiatric disorders
The behavioural variant of frontotemporal dementia (bvFTD) often overlaps clinically with primary psychiatric disorders (P...
Cannabidiol releases CB1R from A2AR repression in ischemic stroke
Cannabidiol (CBD) is a phytocannabinoid with potential in one of the most prevalent syndromes occurring at birth, the hypo...
PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner
The integrated stress response (ISR) modulates protein homeostasis in response to both intracellular and extracellular sig...
Enrichment of phosphorylated Tau 181 levels in tear fluid-derived extracellular vesicles
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular amyloid-β (Aβ) plaques and intrace...
APOE4 carriership status influences [11C]PiB white matter retention in cognitively healthy older adults
PurposeThe objective of this study was to assess whether APOE4 carriership status affects white matter (WM) [11C]PiB posit...
An in vivo PET/CT investigation of mitochondrial complex 1, sigma 1, and synaptic vesicle 2 A in patients with amyotrophic lateral sclerosis
BackgroundAmyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder which pathology is still largely...
A novel post-witness social defeat stress model induces robust dorsal hippocampal synaptic and behavioral deficits
Chronic stress disrupts brain homeostasis, contributing to cognitive and emotional dysfunction in patients with psychiatri...
A new serological autoantibody signature associated with multiple sclerosis
The role of autoantibodies in the pathogenesis of Multiple Sclerosis (MS) remains incompletely understood. In this study, ...
Characterizing the distinct neuroanatomical phenotypes, cognitive profiles, and transcriptomic signatures of brain structural subtypes in Parkinson's disease with mild cognitive impairment
The datasets analyzed during the current study are not publicly available due to patient privacy and confidentiality requi...
Dendritic retraction contributes to spine density recovery following denervation in vitro
Neurodegenerative diseases cause local brain lesions as well as denervation of neurons in areas connected to the lesion si...
FMRP attenuates Tau pathology through the CDK5/p35 signaling pathway
Volume 216, November 2025, 107145Author links open overlay panel, , , , , , , , , , , Highlights•FMRP levels are reduced i...
Retention of lysosomal acid sphingomyelinase protects from Niemann-Pick Disease
Niemann-Pick Disease (NPD) types A and B are lysosomal storage disorders resulting from dysfunction or loss of acid sphing...
White matter degeneration precedes tau aggregation in rats with Alzheimer's-like tauopathy
Tau pathology is increasingly recognized as a primary driver of white matter (WM) microstructural damage in tauopathies, p...
Deep brain stimulation rescues the homeostasis disruption of circulating D- and L-amino acids level in men with Parkinson's disease
Recent evidence indicates a marked downregulation of circulating D- and L-amino acids involved in regulating glutamatergic...
An inducible oligodendrocyte dysfunction triggered a pathological cascade of massive microglial activation and neurodegeneration
Volume 216, November 2025, 107142Author links open overlay panel, , , , , , Highlights•Deletion of Ddx20 in mature oligode...
Pancreatic hypersecretion of amyloid-forming human amylin dysregulates the neuro-immune axis and B cell development in a model of type-2 diabetes
During Type 2 diabetes (T2D), the immune system becomes dysregulated, adopting a pro-inflammatory phenotype and secreting ...
Considering Big tau as a novel and specific biomarker for spinal motor neuron pathology
Big tau is an isoform of tau that includes the large 4 A exon, resulting in an extended projection domain and an overall i...
Attenuated neurotoxicity after repeated methamphetamine binges linked to dopamine transporter (DAT) decline
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Long-term exposure to anti-GluA3 antibodies triggers functional and structural changes in hippocampal neurons
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Impairment in the homeostatic recruitment of layer 5/6 neurons following whisker stimulation in Fmr1 KO mice
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Abnormal neuronal activity in the subthalamic nucleus contributes to dysarthria in patients with Parkinson's disease
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Peripheral blood immune cells from individuals with Parkinson's disease or inflammatory bowel disease share deficits in iron storage and transport that are modulated by non-steroidal anti-inflammatory drugs
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B cells upregulate NMDARs, respond to extracellular glutamate, and express mature BDNF to protect the brain from ischemic injury
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Insights into dentatorubral-pallidoluysian atrophy from a new Drosophila model of disease
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A missense variant in DEPDC5 resulted in abnormal morphology and increased seizure susceptibility and mortality through regulating mTOR signaling
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Deficits in taste-guided behaviors and central processing of taste in the transgenic TDP-43Q331K mouse model of frontotemporal dementia
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WTAP suppresses STAT3 via m6A methylation to regulate autophagy and inflammation in central nervous system injury
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