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Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming
Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder marked by progressive motor neuron (MN) degenera...
Parsing autism spectrum heterogeneity through fMRI
Parsing autism spectrum heterogeneity through fMRI
Autism is remarkably heterogeneous, posing a long-standing challenge for linking genetics to brain dynamics. A cross-speci...
Excitatory synapses onto axonic spines jump-start action potentials and route information flow
Excitatory synapses onto axonic spines jump-start action potentials and route information flow
Synaptic inputs onto the dendrites and cell body integrate and trigger action potentials (APs) at the axon initial segment...
Autism subtypes identified using cross-species functional connectivity analyses
Autism subtypes identified using cross-species functional connectivity analyses
It is often assumed that phenotypic heterogeneity in autism reflects underlying pathobiological variation. However, direct...
Spatial proteomic analysis in human Alzheimer’s disease brains enables identification of microenvironment-dependent microglial cell states
Spatial proteomic analysis in human Alzheimer’s disease brains enables identification of microenvironment-dependent microglial cell states
Disease-associated microglial states are thought to contribute to Alzheimer’s disease (AD) progression, but characte...
Considering biological limitations of lesion network mapping
Considering biological limitations of lesion network mapping
Lesion network mapping (LNM), or atrophy network mapping, has become a widely adopted tool for linking focal brain lesions...
Tau aggregates cause reactivation of transposable DNA elements, leading to Z-RNA–ZBP1-mediated neuronal death
Tau aggregates cause reactivation of transposable DNA elements, leading to Z-RNA–ZBP1-mediated neuronal death
Once tau aggregates are formed, their neurotoxicity significantly contributes to neuronal death and cognitive decline in t...
Foamy microglia link oxylipins to disease progression in multiple sclerosis
Foamy microglia link oxylipins to disease progression in multiple sclerosis
Multiple sclerosis (MS) is a chronic neuroinflammatory disease in which demyelinating white matter lesions accumulate and ...
Temporal integration in human auditory cortex is predominantly yoked to absolute time
Temporal integration in human auditory cortex is predominantly yoked to absolute time
Sound structures such as phonemes and words have highly variable durations. Therefore, there is a fundamental difference b...
A bottom-up septal inhibitory circuit mediates anticipatory control of drinking
A bottom-up septal inhibitory circuit mediates anticipatory control of drinking
Drinking behavior is not only homeostatically regulated but also rapidly adjusted before any changes in blood osmolality o...
Hormonal milieu influences whole-brain structural dynamics across the menstrual cycle using dense sampling in multiple individuals
Hormonal milieu influences whole-brain structural dynamics across the menstrual cycle using dense sampling in multiple individuals
Gonadal hormone receptors are widely distributed across the brain, yet their influence on brain structure remains understu...
Towards the implementation of Indigenous data governance in neurogenomics research
The promise of genomics-focused neuroscience to improve health outcomes for Indigenous Peoples depends on ensuring more eq...
Facial expressions in mice reveal latent cognitive variables and their neural correlates
Facial expressions in mice reveal latent cognitive variables and their neural correlates
Brain activity controls adaptive behavior but also drives unintentional incidental movements. Such movements could potenti...
Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain
Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain
Chronic pain and mood disorders co-occur, exacerbate one another and share neurobiological mechanisms, but whether a singl...
Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape
Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape
The skull marrow niche has recently been identified as a reservoir that supplies the brain with monocytes and neutrophils ...
Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models
Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models
Amyotrophic lateral sclerosis (ALS) is characterized by neuromuscular junction (NMJ) disruption and neurodegeneration. Rec...
Separating cognitive and motor processes in the behaving mouse
Separating cognitive and motor processes in the behaving mouse
The cognitive processes supporting complex animal behavior are closely associated with movements responsible for critical ...
The developmental emergence of reliable cortical representations
The developmental emergence of reliable cortical representations
The fundamental structure of cortical networks arises early in development before the onset of sensory experience. However...
Non-REM sleep substates separate old and new memories
Memories are replayed during non-REM sleep, but it has remained unclear how replays of recent and older experiences remain...
Prenatal stress effects on the placenta
Maternal stress has been identified as a critical factor that influences the long-term health of offspring across generati...
Charting the development of human dorsal root ganglia
Dorsal root ganglia (DRG) are diverse clusters of somatosensory neurons and glia involved in detecting sensory stimuli. A ...
Latent circuit inference from heterogeneous neural responses during cognitive tasks
Latent circuit inference from heterogeneous neural responses during cognitive tasks
Higher cortical areas carry a wide range of sensory, cognitive and motor signals mixed in heterogeneous responses of singl...
A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics
A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics
For accurate perception and motor control, an animal must distinguish between sensory experiences elicited by external sti...
Author Correction: The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
In conversation with Ukpong Eyo
In conversation with Ukpong Eyo
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
In conversation with Kelsey Martin
In conversation with Kelsey Martin
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
Updating the striatal–pallidal wiring diagram
Updating the striatal–pallidal wiring diagram
The striatal and pallidal complexes are basal ganglia structures that orchestrate learning and execution of flexible behav...
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading cause of cognitive impairmen...
Myelin and Alzheimer’s disease
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
How we promote data sharing
In 2022, we began a pilot to facilitate data sharing for manuscripts submitted to Nature Neuroscience. Here, we analyze it...
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