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Large-scale electrophysiology at single-spike resolution
Large-scale electrophysiology at single-spike resolution
Recent advances in electrode technology — including the development of Neuropixels and SiNAPS probes — have ma...
Rethinking hierarchy: the auditory system as an integrated cortical–subcortical network
Rethinking hierarchy: the auditory system as an integrated cortical–subcortical network
Mammalian sensory systems are traditionally viewed as hierarchical pathways in which subcortical nuclei relay signals from...
Mapping the molecular effects of Down syndrome in the developing brain
Two studies use single-nucleus multiomic sequencing to profile molecular and cellular dysfunction in the prenatal and earl...
Linking the exposome to the brain–behaviour phenotype
Linking the exposome to the brain–behaviour phenotype
A range of environmental, lifestyle and biological exposures across the lifespan — varying in timing, duration and i...
Neural basis of social hierarchy across species
Neural basis of social hierarchy across species
A social hierarchy is an ordered ranking of individuals that arises through their interactions and governs relative access...
Metabolic vulnerability and tau pathology in combination drive necroptosis
Neuronal loss in a mouse model of Alzheimer disease occurs through necroptosis and is shown to be dependent on low-glucose...
When inhibition organizes the brain
In this Journal Club, Renata Batista-Brito discusses a 2009 study that showed that a population of inhibitory hub neurons ...
Resolving rapid cell-surface proteome remodelling in intact neural circuits
In this Tools of the Trade article, Colleen McLaughlin describes endocytome profiling, a systematic and quantitative appro...
The short and long pathways to memory
Inhibition of CaMKII blocks short-term memory but not long-term memory of inhibitory avoidance in mice.
Human hippocampal circuit characterization
A new study reveals distinct circuit features of the human hippocampal CA3 region.
Pathways to sex preferences
A study explores the sexually dimorphic circuits that regulate sociosexual preferences in mice.
Early spinal cord development: from neural tube formation to neurogenesis
Early spinal cord development: from neural tube formation to neurogenesis
As one of the simplest and most evolutionarily conserved parts of the vertebrate nervous system, the spinal cord serves as...
Lipid metabolism, remodelling and intercellular transfer in the CNS
Lipid metabolism, remodelling and intercellular transfer in the CNS
Lipid metabolism encompasses the catabolism and anabolism of lipids, and is fundamental for the maintenance of cellular ho...
Three systems of circuit formation: assembly, updating and tuning
Three systems of circuit formation: assembly, updating and tuning
Understanding the relationship between genotype and neuronal circuit phenotype necessitates an integrated view of genetics...
Sensory cortex quashes subcortical escape instinct
A modified looming paradigm teases apart how top-down cortical inputs from visual areas can override instinctive fear resp...
How eating makes asthma worse
A possible mechanism underlying the worsening of asthma symptoms after eating is found in mice, where type 2 immunity in t...
Preparing for motherhood
In mice, specific pools of adult neural stem cells are recruited during pregnancy to support postpartum maternal behaviour.
The neurobiology of SARS-CoV-2 infection
The neurobiology of SARS-CoV-2 infection
Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated 55–60% of those infected de...
The long COVID haul
Ongoing systemic and neurocognitive impairments that continue in a subset of individuals after infection with SARS-CoV-2 i...
The generative grammar of the brain: a critique of internally generated representations
The generative grammar of the brain: a critique of internally generated representations
The past decade of progress in neurobiology has uncovered important organizational principles for network preconfiguration...
Sleep and circadian rhythmicity as entangled processes serving homeostasis
Sleep and circadian rhythmicity as entangled processes serving homeostasis
Sleep is considered essential for the brain and body. A predominant concept is that sleep is regulated by circadian rhythm...
From local APP expression to network dysfunction
In mice, localized mutant APP expression in the CA3 hippocampal region leads to progressive network dysfunction and hippoc...
Human neuronal maturation comes of age: cellular mechanisms and species differences
Human neuronal maturation comes of age: cellular mechanisms and species differences
The delayed and prolonged postmitotic maturation of human neurons, compared with neurons from other species, may contribut...
Sometimes science needs a stubborn mind: the discovery of dopamine
Federica De Lazzari describes Arvid Carlsson’s 1957 paper, which provided evidence for the importance of dopamine in...
Playing tag at the axon
A new biotinylation-based approach identifies previously unknown cell surface proteins of the axonal initial segment (AIS)...
How deep is the brain? The shallow brain hypothesis
How deep is the brain? The shallow brain hypothesis
Deep learning and predictive coding architectures commonly assume that inference in neural networks is hierarchical. Howev...
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Many social behaviours are evolutionarily conserved and are essential for the healthy development of an ...
Coding number estimates
A new study shows that, in a numerical judgement task, individuals show differences in neuronal coding of numbers below an...
Boundary deprivation does not prevent grid cell maturation
Grid cells develop in rats soon after they leave the nest. Here, Ulsaker-Janke et al. show that preventing exposure to str...
Caught in a trap
Ketamine is ‘trapped’ in the pores of NMDA receptors in the lateral habenula, mediating sustained antidepressa...
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