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AR antagonist IDPU facilitates the restoration of mitochondrial dynamics in 6-OHDA-induced primary mid-brain neuronal cells, via regulating p38MAPK/Parkin/DJ-1/DRP1 axis
AR antagonist IDPU facilitates the restoration of mitochondrial dynamics in 6-OHDA-induced primary mid-brain neuronal cells, via regulating p38MAPK/Parkin/DJ-1/DRP1 axis
Parkinson’s disease (PD) is marked by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc)....
In tribute to Francesco Di Virgilio, a great scientist and a wonderful friend
In tribute to Francesco Di Virgilio, a great scientist and a wonderful friend
Francesco Di Virgilio, one of the giants of purinergic signalling, died suddenly on September 22, 2024, which is an immens...
Purinergic P2X7 receptor signaling in anxiety: Roles of stress-related neuroinflammatory mechanisms and therapeutic horizons
Purinergic P2X7 receptor signaling in anxiety: Roles of stress-related neuroinflammatory mechanisms and therapeutic horizons
Anxiety is a psychological state marked by constant uneasiness, fear, or stress in response to an actual or perceived dang...
Modulation of immune responses by opioids through toll-like and P2X receptor signaling in COVID-19
Modulation of immune responses by opioids through toll-like and P2X receptor signaling in COVID-19
The pathogenesis of COVID-19 involves complex interactions between viral replication and host immune dysregulation, mediat...
Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor
Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor
The transition of fibroblast-like synoviocytes (FLS) toward a proinflammatory phenotype is a hallmark of rheumatoid arthri...
The biphasic regulatory effect of adenosine A2B receptor in ischemic brain injury and its therapeutic potential
The biphasic regulatory effect of adenosine A2B receptor in ischemic brain injury and its therapeutic potential
Ischemic brain injury is the leading cause of neurological disability and death worldwide. Adenosine A2B receptor (A2BR) i...
The potential role of adenosinergic pathway and methylxanthines in Parkinson’s disease: Blowing in the wind or not
The potential role of adenosinergic pathway and methylxanthines in Parkinson’s disease: Blowing in the wind or not
Parkinson’s disease (PD) is a systemic neurodegenerative disease, and is mainly related to the progressive degenerat...
The P2X7 receptor/NLRP3 inflammasome signaling axis in sepsis: molecular mechanisms, organ-specific pathophysiology, and emerging therapeutic strategies
The P2X7 receptor/NLRP3 inflammasome signaling axis in sepsis: molecular mechanisms, organ-specific pathophysiology, and emerging therapeutic strategies
Sepsis remains a leading cause of mortality in intensive care units worldwide, representing life-threatening organ dysfunc...
Phenolic compounds and chemotherapeutic agents differentially regulate P2X receptor subtypes in malignant melanoma
Phenolic compounds and chemotherapeutic agents differentially regulate P2X receptor subtypes in malignant melanoma
Melanoma is an aggressive malignancy characterized by high metastatic potential and resistance to conventional therapies. ...
Mixed circuit training as a non-pharmacological strategy to improve platelet function and oxidative balance in type 2 diabetes: role of purinergic signaling
Mixed circuit training as a non-pharmacological strategy to improve platelet function and oxidative balance in type 2 diabetes: role of purinergic signaling
This study investigates the impact of a 16-week mixed circuit training (MCT) program on purinergic signaling and oxidative...
Latest advances on the role of P2X Receptors in colorectal inflammation and cancer
Latest advances on the role of P2X Receptors in colorectal inflammation and cancer
Extracellular adenosine triphosphate (eATP) is a hallmark of inflammatory and tumor-associated microenvironments, where it...
Host-directed therapeutic strategies against apicomplexan parasites: targeting purinergic P2 receptors
Host-directed therapeutic strategies against apicomplexan parasites: targeting purinergic P2 receptors
Apicomplexan parasites establish intracellular infections that profoundly alter host cell physiology and elicit complex im...
Proteasomal-dependent endothelial P2Y receptor downregulation as an adaptive mechanism limiting monocyte adhesion during intestinal schistosomiasis
Proteasomal-dependent endothelial P2Y receptor downregulation as an adaptive mechanism limiting monocyte adhesion during intestinal schistosomiasis
Schistosomiasis, a complex chronic intravascular parasitic disease caused by Schistosoma mansoni, triggers a multifaceted ...
Tumor growth inhibitory activity of the P2X7 receptor antagonist AZ10606120 in two cell lines of human glioblastoma
Tumor growth inhibitory activity of the P2X7 receptor antagonist AZ10606120 in two cell lines of human glioblastoma
Glioblastoma multiforme (GBM) is among the most aggressive and lethal primary brain tumors. P2X7 is a purinergic receptor ...
Expression of purinergic receptor P2Y, G-protein coupled 2, is regulated by estrogen during the estrous cycle in mouse uterus
Expression of purinergic receptor P2Y, G-protein coupled 2, is regulated by estrogen during the estrous cycle in mouse uterus
Elucidating the molecular intricacies governing uterine function is crucial for reproductive success. The purinergic recep...
P2X7 receptor-mediated cGAS-STING pathway activation underlies chronic stress-induced depressive-like behaviors
P2X7 receptor-mediated cGAS-STING pathway activation underlies chronic stress-induced depressive-like behaviors
Although chronic stress is known to trigger neuroinflammation and depressive-like behaviors, the mechanisms linking stress...
P2 receptors signaling in the esophagus: from inflammation to cancer
P2 receptors signaling in the esophagus: from inflammation to cancer
The signaling mechanisms of nucleotides and nucleosides have been extensively studied over the past decades in various con...
Role of macrophage ATP metabolism disorder in SiO‑induced pulmonary fibrosis: a review
Role of macrophage ATP metabolism disorder in SiO‑induced pulmonary fibrosis: a review
Silicosis, a chronic lung disease, results from prolonged inhalation of silica dust (SiO2) in occupational environments, a...
Depletion of P2X4 receptor alleviates prostate cancer bone metastasis through reduced cancer cell invasiveness and enhanced cell adhesion activities
Depletion of P2X4 receptor alleviates prostate cancer bone metastasis through reduced cancer cell invasiveness and enhanced cell adhesion activities
Prostate cancer (PCa) preferentially metastasizes to bone, which remains incurable and contributes significantly to mortal...
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock
Hemorrhagic shock (HS) leads to systemic hypoperfusion, impaired tissue oxygenation, and multi-organ dysfunction, includin...
State of the art indicators for imaging purinergic dynamics in vitro and in vivo
State of the art indicators for imaging purinergic dynamics in vitro and in vivo
Purinergic neurotransmission, a dynamic signaling system using adenosine triphosphate (ATP), adenosine diphosphate (ADP), ...
Electroacupuncture alleviates capsaicin-induced rectal visceral pain in rats via inhibiting TRPV1 expression by blocking the P2X4R-activated p38 pathway
Electroacupuncture alleviates capsaicin-induced rectal visceral pain in rats via inhibiting TRPV1 expression by blocking the P2X4R-activated p38 pathway
Electroacupuncture (EA), as a combination of traditional acupuncture and modern electrotherapy, and has analgesic effects ...
The CALHM1 blocker CGP37157 increases seizure severity during status epilepticus in adult mice
The CALHM1 blocker CGP37157 increases seizure severity during status epilepticus in adult mice
Epilepsy is one of the most common chronic brain diseases affecting up to 70 million people worldwide. Major challenges of...
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
Endometriosis is a chronic gynecological condition characterized by endometrial tissue outside the uterine cavity. Recent ...
Therapeutic potential of P2X7 receptor in retinal diseases
Therapeutic potential of P2X7 receptor in retinal diseases
Retinal diseases affect the health of millions of people worldwide and activated P2X7 receptors (P2X7Rs) are associated wi...
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
Correction to: Purinergic SignallingUnfortunately, the original published version of ...
Adenosine receptors and acute kidney injury: perspectives for future therapy
Adenosine receptors and acute kidney injury: perspectives for future therapy
Adenosine is a key modulator in the pathophysiology of acute kidney injury (AKI), particularly through its influence on in...
Adenine at lower doses acts in the kidney as an aquaretic agent and prevents hyponatremia
Adenine at lower doses acts in the kidney as an aquaretic agent and prevents hyponatremia
We have previously reported that adenine at high doses interferes with the vasopressin signaling pathway, causes massive d...
The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential
The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential
The P2X7 receptor is a trimeric ion channel purinergic receptor. It plays a crucial part in the pathophysiology of cancers...
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex
Increasing evidence indicated that purinergic signalling involved in electroacupuncture (EA)-induced analgesia. Whether pu...
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