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Dynamic immune and metabolic dysregulation in women with post-traumatic stress disorder: Longitudinal transcriptomic insights following sexual assault
Dynamic immune and metabolic dysregulation in women with post-traumatic stress disorder: Longitudinal transcriptomic insights following sexual assault
Post-traumatic stress disorder (PTSD) is a chronic and debilitating psychiatric condition, and sexual assault represents t...
Associations between REM sleep EEG slowing and brain cholinergic denervation in aging and Mild Cognitive Impairment
Associations between REM sleep EEG slowing and brain cholinergic denervation in aging and Mild Cognitive Impairment
Cholinergic activity supports cortical activation during REM sleep, while other neurotransmitter systems are almost silent...
Revolutionizing MDD diagnosis: the integrated role of circRNAs and biosensor technology
Revolutionizing MDD diagnosis: the integrated role of circRNAs and biosensor technology
Major Depressive Disorder (MDD) is a globally widespread mental health disorder that frequently remains underdiagnosed and...
Thalamo-cortical white matter connectivity-defined thalamic subarea volumes predict individual delay discounting
Thalamo-cortical white matter connectivity-defined thalamic subarea volumes predict individual delay discounting
Delay discounting (DD), the tendency to favor smaller, immediate rewards over larger, delayed rewards, is associated with ...
Grin2a knockout in adolescent dopamine neurons disrupts prediction error signaling and produces a phenotype relevant to schizophrenia
Grin2a knockout in adolescent dopamine neurons disrupts prediction error signaling and produces a phenotype relevant to schizophrenia
Adolescence is associated with the emergence of several psychiatric disorders including schizophrenia. Recent studies have...
The role of sphingolipids in major depressive disorder and associated cognitive impairment: interactions with monoaminergic signaling, neuroinflammation, and neurogenesis
The role of sphingolipids in major depressive disorder and associated cognitive impairment: interactions with monoaminergic signaling, neuroinflammation, and neurogenesis
Major depressive disorder (MDD) represents a leading cause of disability. Despite decades of research focused on monoamine...
Nitrous oxide controls the DCN to VTA dopamine circuit by enhancing AMPA receptor functions during rewarding behavior
Nitrous oxide controls the DCN to VTA dopamine circuit by enhancing AMPA receptor functions during rewarding behavior
Nitrous oxide (N2O) is a frequently used recreational drug with significant addictive potential. The ventral tegmental are...
Maternal fasting during early gestation induces epigenetic alterations and schizophrenia-related phenotypes
Maternal fasting during early gestation induces epigenetic alterations and schizophrenia-related phenotypes
Schizophrenia is a severe neurodevelopmental disorder whose etiology remains incompletely understood. Epidemiological stud...
Mapping symptom-general and symptom-specific targets for transcranial magnetic stimulation in schizophrenia: an electric-field modeling meta-analysis
Mapping symptom-general and symptom-specific targets for transcranial magnetic stimulation in schizophrenia: an electric-field modeling meta-analysis
Negative, positive, and cognitive symptoms of schizophrenia relate to disruptions in partially distinct brain circuits. Al...
Lineage specification into GABAergic, glutamatergic, dopaminergic, and astrocytic phenotypes using MUSE stem cells: a novel approach for modeling neurodegenerative and psychiatric disorders
Lineage specification into GABAergic, glutamatergic, dopaminergic, and astrocytic phenotypes using MUSE stem cells: a novel approach for modeling neurodegenerative and psychiatric disorders
The study of neurodegenerative and psychiatric disorders is often hampered by the limited accessibility of relevant neural...
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa
Anorexia nervosa (AN) has extensive genetic correlations with other psychiatric disorders, and genetic risk for different ...
The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mouse model of local amyloid pathology
The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mouse model of local amyloid pathology
Patient and animal model data suggest a link between the cholinergic neuromodulatory system and the amyloid beta (Aβ)...
Increased expression of ATase1/NAT8B or ATase2/NAT8 in the mouse results in an autistic-like phenotype with altered dendritic branching and spine formation
Increased expression of ATase1/NAT8B or ATase2/NAT8 in the mouse results in an autistic-like phenotype with altered dendritic branching and spine formation
Neurons heavily depend on the ability of the secretory pathway to deliver correctly folded polypeptides to the periphery o...
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all herita...
Maternal psychiatric disorders before, during, and after pregnancy: a national cohort study in Sweden
Maternal psychiatric disorders before, during, and after pregnancy: a national cohort study in Sweden
Maternal mental health is a critical public health issue, yet the evidence on rates of incident psychiatric disorders befo...
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Frontotemporal dementia (FTD) is the second most common cause of dementia in patients under 65 years, characterized by div...
Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models
Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models
Most of the fear literature on humans and animals tests healthy individuals. However, fear memories can differ between hea...
Dopaminergic deficits along the spectrum of Alzheimer’s disease
Dopaminergic deficits along the spectrum of Alzheimer’s disease
Both post-mortem and in vivo data argue for dopamine dysfunction in patients with Alzheimer’s Disease (AD). However,...
Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence
Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence
Laboratory studies show brain maturation involves synaptic pruning and cognitive development. Human studies suggest links ...
Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells
Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells
Alterations induced by maternal immune activation (MIA) during gestation impact the subsequent neurodevelopment of progeny...
Neural correlates of personal space regulation in psychosis: role of the inferior parietal cortex
Neural correlates of personal space regulation in psychosis: role of the inferior parietal cortex
Regulation of interpersonal distance or “personal space” (PS; the space near the body into which others cannot...
Correction: Probing the genetic and molecular correlates of connectome alterations in obsessive-compulsive disorder
Authors and AffiliationsDepartamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de...
βIV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia
βIV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia
Schizophrenia (SCZ) is a complex psychiatric disorder with unclear biological mechanisms. Spectrins, cytoskeletal proteins...
The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study
The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study
Late-life depression (LLD) has been linked to increased likelihood of dementia, although mechanisms responsible for this a...
Correction: Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
Feinstein Institutes for Medical Research, Institute of Behavioral Science, Manhasset, NY, USAMiklos Argyelan, Brian Angul...
Oxytocin activity in the paraventricular and supramammillary nuclei of the hypothalamus is essential for social recognition memory in rats
Oxytocin activity in the paraventricular and supramammillary nuclei of the hypothalamus is essential for social recognition memory in rats
Oxytocin plays an important role in modulating social recognition memory. However, the direct implication of oxytocin neur...
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methyl...
“Puberty age gap”: new method of assessing pubertal timing and its association with mental health problems
“Puberty age gap”: new method of assessing pubertal timing and its association with mental health problems
Puberty is linked to mental health problems during adolescence, and in particular, the timing of puberty is thought to be ...
Choroid plexus and perivascular space enlargement in neuropsychiatric systemic lupus erythematosus
Choroid plexus and perivascular space enlargement in neuropsychiatric systemic lupus erythematosus
Choroid plexus (CP) enlargement is proposed as a marker of neuroinflammation in immune-mediated conditions. CP involvement...
The neural signature of psychomotor disturbance in depression
The neural signature of psychomotor disturbance in depression
Up to 70% of patients with major depressive disorder present with psychomotor disturbance (PmD), but at the present time u...
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