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Targeting Microglial Activation to Modulate Neuroinflammation in Alzheimer’s Disease
Targeting Microglial Activation to Modulate Neuroinflammation in Alzheimer’s Disease
Alzheimer’s disease is a multifaceted neurodegenerative condition marked by the build-up of amyloid plaques and neur...
Genetic Evidence Linking Lactylation-Related Gene Expression To Dementia Risk
Genetic Evidence Linking Lactylation-Related Gene Expression To Dementia Risk
Lactylation has been identified as a novel epigenetic modification involved in neuroinflammation, mitochondrial dysfunctio...
SAT1 Knockdown Decreases Glutamate-Induced Oxidative Stress, Ferroptosis, and Apoptosis in HT22 Cells via Activating the Nrf2/ARE Pathway
SAT1 Knockdown Decreases Glutamate-Induced Oxidative Stress, Ferroptosis, and Apoptosis in HT22 Cells via Activating the Nrf2/ARE Pathway
Glutamate toxicity is involved in the pathogenesis of neurological disorders, including epilepsy. Here we aimed to investi...
Anti-Inflammatory Potential of Stearidonic Acid Ethanolamide in a Model of Mild Traumatic Brain Injury in Mice
Anti-Inflammatory Potential of Stearidonic Acid Ethanolamide in a Model of Mild Traumatic Brain Injury in Mice
Chronic neuroinflammation is recognized as a pivotal mechanism responsible for secondary damage following mild traumatic b...
Neuronal Subtype-Specific Expression of γ-Enolase: Its Role in Neuronal Differentiation
Neuronal Subtype-Specific Expression of γ-Enolase: Its Role in Neuronal Differentiation
Neuronal differentiation into specific subtypes is crucial for nervous system development and function, guided by neurotro...
Myelin Lipid Reserves as a Conditional Metabolic Buffer: Implications for Alzheimer’s Disease and Ischemic Stroke
Myelin Lipid Reserves as a Conditional Metabolic Buffer: Implications for Alzheimer’s Disease and Ischemic Stroke
Brain energetics rely on a distributed partnership among cell types and fuel sources. Beyond astrocytic glycogen, the brai...
In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2
In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2
The Presenilins are multi-pass transmembrane proteins that form part of the multi-protein gamma secretase complex. The hyd...
Spinal Cord Involvement in Patients with Adult-Onset Multiple Acyl-CoA Dehydrogenase Deficiency
Spinal Cord Involvement in Patients with Adult-Onset Multiple Acyl-CoA Dehydrogenase Deficiency
Riboflavin responsive multiple acyl-CoA dehydrogenase deficiency (RR-MADD) is an inherited metabolic disorder which is goo...
Phloretin as a Multitarget Neuroprotective Agent: Mechanistic Insights into the Modulation of Oxidative Stress, Inflammation, and Apoptosis
Phloretin as a Multitarget Neuroprotective Agent: Mechanistic Insights into the Modulation of Oxidative Stress, Inflammation, and Apoptosis
Neurodegenerative diseases impose a substantial and growing global burden, affecting millions worldwide and leading to hig...
Simvastatin Ameliorates Lipid Metabolism-Mediated Endothelial Inflammation and Tight Junction Impairment in Chronic Cerebral Hypoperfusion
Simvastatin Ameliorates Lipid Metabolism-Mediated Endothelial Inflammation and Tight Junction Impairment in Chronic Cerebral Hypoperfusion
Chronic cerebral hypoperfusion (CCH) is a key pathological hallmark observable in multiple subtypes of cerebral small vess...
Searching for New Possible Peripheral Biomarkers of Cognitive Decline in Down Syndrome: The Role of IL-18 Pathway and its Interaction with TGF-β1 and TNF-α
Searching for New Possible Peripheral Biomarkers of Cognitive Decline in Down Syndrome: The Role of IL-18 Pathway and its Interaction with TGF-β1 and TNF-α
Down syndrome (DS) represents one of the most common genetic disorders attributable to a partial or complete trisomy of ch...
Pterostilbene Orchestrates Synaptic Remodeling and Mitochondrial Functional Reconstitution to Attenuate Ischemic Vascular Dementia
Pterostilbene Orchestrates Synaptic Remodeling and Mitochondrial Functional Reconstitution to Attenuate Ischemic Vascular Dementia
Vascular dementia (VaD), a major contributor to cognitive decline, arises primarily from impaired regulation of cerebral c...
Montelukast Modulates MPTP-induced Ferroptosis and Neuroinflammation Linked To the GPX4/ACSL4/5-LOX Pathway
Montelukast Modulates MPTP-induced Ferroptosis and Neuroinflammation Linked To the GPX4/ACSL4/5-LOX Pathway
Ferroptosis, an iron-dependent form of regulated cell death, has been increasingly linked to neurodegeneration in Parkinso...
Early-Age Cuprizone Exposure Induces Region-Specific Demyelination and Neuroinflammation in Mice
Early-Age Cuprizone Exposure Induces Region-Specific Demyelination and Neuroinflammation in Mice
Myelin, essential for rapid nerve conduction and axonal integrity in the central and peripheral nervous systems, is compro...
Miro1 in Parkinson’s Disease: A Key Regulator of Mitochondrial Homeostasis and Neurodegeneration
Miro1 in Parkinson’s Disease: A Key Regulator of Mitochondrial Homeostasis and Neurodegeneration
Parkinson’s disease (PD), is slowly advancing disease condition of the nervous system, which leads to interruption o...
B4Galnt1 Deficiency Reverses Severe Neurological Symptoms in a Mouse Model of Tay-Sachs Disease
B4Galnt1 Deficiency Reverses Severe Neurological Symptoms in a Mouse Model of Tay-Sachs Disease
Tay-Sachs disease is a severe neurodegenerative disorder caused by mutations in the HEXA gene, which encodes the α-su...
Lipocalin-2 in Intracerebral Hemorrhage: Mechanisms, Biomarker Potential, and Therapeutic Targeting
Lipocalin-2 in Intracerebral Hemorrhage: Mechanisms, Biomarker Potential, and Therapeutic Targeting
Intracerebral hemorrhage (ICH) is a severe stroke subtype characterized by high mortality and disability rates. Secondary ...
Soluble Urokinase-type Plasminogen Activator Receptor (suPAR) as a Biomarker of Neurodysfunction
Soluble Urokinase-type Plasminogen Activator Receptor (suPAR) as a Biomarker of Neurodysfunction
The inflammatory response is essential for host defense, but its persistence can lead to chronic systemic inflammation (CS...
Genistein mitigates estrogen deficiency and chronic stress-induced neuronal dysfunction via targeting ER-β, oxidative stress, inflammation, and apoptosis
Genistein mitigates estrogen deficiency and chronic stress-induced neuronal dysfunction via targeting ER-β, oxidative stress, inflammation, and apoptosis
Both postmenopausal estrogen decline and chronic unpredictable mild stress (CUMS) contribute to the onset and progression ...
Hydro-Alcoholic Extract of Ameliorates Malathion-Induced Neurocognitive Behavior and Neurotoxicity
Hydro-Alcoholic Extract of Ameliorates Malathion-Induced Neurocognitive Behavior and Neurotoxicity
Organophosphate insecticides like malathion, though less toxic than other compounds in the same class, remain a significan...
Molecular Determinants of A9 Dopaminergic Neurons
Molecular Determinants of A9 Dopaminergic Neurons
In the human brain, the nigrostriatal pathway regulates motor functions, and its selective deterioration leads to the onse...
Protective Effect of the LRRK2 Kinase Inhibition in Human Fibroblasts Bearing the Genetic Variant GBA1 K198E: Implications for Parkinson’s Disease
Protective Effect of the LRRK2 Kinase Inhibition in Human Fibroblasts Bearing the Genetic Variant GBA1 K198E: Implications for Parkinson’s Disease
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder for which there are currently no cura...
Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative Diseases
Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative Diseases
Tauopathies, including Alzheimer’s disease and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FT...
Memory-Enhancing Effects of Dauricine in Mice: Possible Molecular Interventions Through In Vivo and In Silico Studies
Memory-Enhancing Effects of Dauricine in Mice: Possible Molecular Interventions Through In Vivo and In Silico Studies
The bisbenzylisoquinoline alkaloid dauricine (DAU) is known for its neuroprotective effects in animals. This study investi...
Xanthoxylin Regulating the Inflammatory Microenvironment After Spinal Cord Injury Through Inhibition of the NF-κB Signaling Pathway
Xanthoxylin Regulating the Inflammatory Microenvironment After Spinal Cord Injury Through Inhibition of the NF-κB Signaling Pathway
Spinal Cord Injury (SCI) is a severe disorder of the central nervous system, typically caused by trauma or disease, which ...
Knockdown of RUNX2 Attenuated A1 Astrocyte Overactivation, Brain Injury, and Cerebral Edema During Ischemic Stroke
Knockdown of RUNX2 Attenuated A1 Astrocyte Overactivation, Brain Injury, and Cerebral Edema During Ischemic Stroke
Although researchers began to unravel the potential significance of Runt-related transcription factor 2 (RUNX2) in some of...
Scopoletin Attenuates Reserpine-Induced Pain-Depression Dyad in Mice via Modulation of Inflammation, Oxidative Stress, and Monoaminergic Pathways
Scopoletin Attenuates Reserpine-Induced Pain-Depression Dyad in Mice via Modulation of Inflammation, Oxidative Stress, and Monoaminergic Pathways
Pain and depression frequently are comorbid and have common mechanisms such as monoamine depletion, inflammation, an...
Ca-Affinitive and Non-Ca-Affinitive Synaptotagmins in Human Pan-cancer
Ca-Affinitive and Non-Ca-Affinitive Synaptotagmins in Human Pan-cancer
Synaptotagmins (Syts) are a family of crucial Ca2+ sensors for cellular secretions, while half of the Syt isoforms are evo...
Inflammatory Markers and their Relationship with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment. Systematic Review and Meta-Analysis
Inflammatory Markers and their Relationship with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment. Systematic Review and Meta-Analysis
This study estimates the association between blood levels of inflammatory markers and cognitive function in adults with Al...
Exploring Core Genes Involved in Ischemic Stroke and the Therapeutic Potential of Hyperbaric Oxygen: Insights from Transcriptomic Analysis
Exploring Core Genes Involved in Ischemic Stroke and the Therapeutic Potential of Hyperbaric Oxygen: Insights from Transcriptomic Analysis
Ischemic stroke (IS) is a complex neurological disorder caused by reduced cerebral blood flow, typically resulting in tiss...
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