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Blood–spinal cord barrier disruption after spinal cord injury: a time-dependent mechanistic review
The blood–spinal cord barrier (BSCB) is a specialized vascular interface that preserves spinal cord homeostasis by regulat...
Serum NfL and GFAP in post-COVID syndrome: minimal evidence of CNS injury after adjusting for confounders
BackgroundPost-COVID syndrome (PCS) often includes neurological symptoms, but evidence for persistent CNS injury remains i...
Stochasticity in action potential backpropagation: consequences for neuronal computation
In cortical and hippocampal pyramidal neurons, backpropagating action potentials (bAPs) play a central role in dendritic s...
miR-19a-3p and miR-19b-3p repress Nurr1 and Nur77 to promote microglial inflammation after spinal cord injury
BackgroundSpinal cord injury (SCI)-induced neuropathic pain affects up to 60% of individuals with SCI and is closely linke...
Etifoxine drives macrophage M2 polarization via Schwann cell-derived progesterone activation of PPARγ to accelerate peripheral nerve repair
BackgroundPeripheral nerve injury (PNI) presents a significant clinical challenge due to limited endogenous regenerative c...
Impaired myelination in multiple sclerosis organoids: p21 links oligodendrocyte dysfunction to disease subtype
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system. The cause of the disease is u...
(Ba,Ca)(Ti,Sn)O3-based piezoelectric ceramics promotes neuroprotection by regulating microglial IL-6/JAK2/STAT3 signaling pathway
ObjectiveTo investigate whether (Ba,Ca)(Ti,Sn)O3-based piezoelectric ceramics (BCTS) provide neuroprotection by inhibiting...
Retraction: Long non-coding RNA TUSC7, a target of miR-23b, plays tumor-suppressing roles in human gliomas
The Journal retracts the 2016 article cited above.Following publication, concerns were raised on PubPeer regarding the int...
Neuropeptide and cytokines expression in long COVID-19 related neuropsychological sequelae: insights into NK1R-mediated neuroinflammation and in silico therapeutic targeting
BackgroundLong COVID-19 causes neurophysiological, cardiopulmonary, and musculoskeletal issues. Increased neuropeptides an...
Editorial: Reviews in non-neuronal cells 2024 & 2025
The Non-Neuronal Cells section in Frontiers in Cellular Neuroscience is delighted to present this Reviews in series highli...
Immaturity of the neuromuscular junction in spinal muscular atrophy mouse models
Spinal muscular atrophy (SMA) is caused by deficiency of the survival motor neuron (SMN) protein and is classically define...
The GPR68-NINJ1 axis: an emerging mechano-chemical checkpoint in blood–brain barrier disruption—a hypothetical framework and therapeutic promise
The blood–brain barrier (BBB) is a critical interface whose failure is a convergent pathological feature of traumatic, isc...
Recreating the human brain: Are assembloids merely descriptive models?
Assembloids, engineered fusions of region-specific brain 3D constructs, have emerged as powerful platforms to study neurod...
Systematic review of literature regarding the isolation of mesenchymal adult stem cells from the olfactory epithelium
Systematic review of literature regarding the isolation of mesenchymal adult stem cells from the olfactory epithelium
BackgroundThe olfactory mucosa has emerged as a promising source of mesenchymal stem cells with neurogenic potential. Thes...
The neurobiological regulatory mechanism of brain edema
Cerebral edema is a common pathological condition associated with a variety of neurological disorders, and its development...
Correction: Histone deacetylase inhibitors are protective in acute but not in chronic models of ototoxicity
A Correction on Histone deacetylase inhibitors are protective in acute but not in chronic models of ototoxicity by Yang, C...
“Mind the Gap”—enlarged perivascular spaces as a potential magnetic resonance imaging biomarker of impaired glymphatic clearance in brain disorders
The abundant capillary network penetrating the brain parenchyma is surrounded by potential tubular, fluid-filled regions r...
Contribution of proprioceptors in the mesencephalic trigeminal nucleus and their surrounding astrocytes to acidic saline-induced chronic jaw muscle pain in rodents
IntroductionChronic jaw muscle pain is a common clinical condition whose etiology remains ill-defined. Using acidic saline...
Utilizing a culture system for horizontal cells to study neural circuit assembly in the developing mouse retina
The precise wiring of the nervous system relies on neurons extending their processes at the right time and place to find t...
Retraction: Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro
Retraction: Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functio...
The impact of maternal anti-inflammatory drugs on surgical anesthesia-induced neuroinflammation and cognitive impairment in offspring mice
The impact of maternal anti-inflammatory drugs on surgical anesthesia-induced neuroinflammation and cognitive impairment in offspring mice
BackgroundThe impact of maternal surgery combined with general anesthesia on neuroinflammation and the development of lear...
Mathematical models of C-type and N-type inactivating heteromeric voltage gated potassium channels
Mathematical models of C-type and N-type inactivating heteromeric voltage gated potassium channels
Voltage gated potassium channels can be composed of either four identical, or different, pore-forming protein subunits. Wh...
Alzheimer’s disease induced neurons bearing PSEN1 mutations exhibit reduced excitability
Alzheimer’s disease induced neurons bearing PSEN1 mutations exhibit reduced excitability
Alzheimer’s disease (AD) is a devastating neurodegenerative condition that affects memory and cognition, characterized by ...
Deprivation of visual input alters specific subset of inhibitory neurons and affect thalamic afferent terminals in V1 of rd1 mouse
Deprivation of visual input alters specific subset of inhibitory neurons and affect thalamic afferent terminals in V1 of rd1 mouse
Retinitis Pigmentosa (RP) is a heterogenous group of inherited disorder, and its progression not only affects the retina b...
ALS-like pathology diminishes swelling of spinal astrocytes in the SOD1 animal model
ALS-like pathology diminishes swelling of spinal astrocytes in the SOD1 animal model
Astrocytes are crucial for the functioning of the nervous system as they maintain the ion homeostasis via volume regulatio...
Quantitative, real-time imaging of spreading depolarization-associated neuronal ROS production
Quantitative, real-time imaging of spreading depolarization-associated neuronal ROS production
Spreading depolarization (SD) causes a massive neuronal/glial depolarization, disturbs ionic homeostasis and deranges neur...
A novel loss-of-function KCNB1 gene variant in a twin with global developmental delay and seizures
A novel loss-of-function KCNB1 gene variant in a twin with global developmental delay and seizures
Human voltage-gated potassium (Kv) channels are expressed by a 40-member gene family that is essential for normal electric...
Manipulation of DHPS activity affects dendritic morphology and expression of synaptic proteins in primary rat cortical neurons
Manipulation of DHPS activity affects dendritic morphology and expression of synaptic proteins in primary rat cortical neurons
Deoxyhypusine synthase (DHPS) catalyzes the initial step of hypusine incorporation into the eukaryotic initiation factor 5...
The role of ferroptosis in neurodegenerative diseases
The role of ferroptosis in neurodegenerative diseases
Ferroptosis represents an iron− and lipid peroxidation (LPO)-mediated form of regulated cell death (RCD). Recent evidence ...
Editorial: Extracellular vesicles: emerging roles in the aged and neurodegenerative brain
Over the past few decades, central nervous system (CNS) and peripheral nervous system (PNS) secreted nanosized extracellul...
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