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Alpha-pinene modulates hippocampal MAPKs/c-Fos pathways during morphine dependence and withdrawal in rats
Alpha-pinene modulates hippocampal MAPKs/c-Fos pathways during morphine dependence and withdrawal in rats
A potential strategy for managing morphine addiction is preventing mitogen-activated protein kinases (MAPKs) activation an...
Methylphenidate reduces rats’ temporal discounting of aversive outcomes
Methylphenidate reduces rats’ temporal discounting of aversive outcomes
Understanding the impact of delayed consequences on decision-making is a scientific goal with important clinical implicati...
Dissecting the role of mineralocorticoid receptors in binge-like alcohol drinking in mice: Finerenone as a potential pharmacotherapy
Dissecting the role of mineralocorticoid receptors in binge-like alcohol drinking in mice: Finerenone as a potential pharmacotherapy
Alcohol use disorder (AUD) is a serious public health issue, for which only few pharmacological treatments are currently a...
A repeated low-dose regimen of MDMA has transient next-day effects on locomotor activity, anxiety-like behavior, and brain serotonin levels, with no effect on anhedonia-like behavior, in both female and male rats
A repeated low-dose regimen of MDMA has transient next-day effects on locomotor activity, anxiety-like behavior, and brain serotonin levels, with no effect on anhedonia-like behavior, in both female and male rats
MDMA (3–4 methylenedioxymethamphetamine) assisted psychotherapy has gained considerable attention as a potential adj...
Dopamine receptor sensitivity, cocaine-induced behaviors, and Pavlovian conditioned approach in male rats
Dopamine receptor sensitivity, cocaine-induced behaviors, and Pavlovian conditioned approach in male rats
Understanding the determinants of individual differences in cue-reactivity and drug sensitivity is critical to identifying...
Acute apocynin-tandospirone derivatives (ATDs) exacerbate methamphetamine-induced hyperlocomotion in rats
Acute apocynin-tandospirone derivatives (ATDs) exacerbate methamphetamine-induced hyperlocomotion in rats
Apocynin–tandospirone derivatives (ATDs) have recently been shown to ameliorate methamphetamine (MAP)-induced behavi...
The effect of cannabis use on the time course of positive and negative affect in the daily life of youth
The effect of cannabis use on the time course of positive and negative affect in the daily life of youth
Contemporary theories of addiction postulate that persistent cannabis use develops in part through the positive and negati...
Decoding the molecular network communication mechanism of ketamine’s antidepressant effects
Decoding the molecular network communication mechanism of ketamine’s antidepressant effects
Major Depressive Disorder (MDD) is a global public health burden, with traditional monoaminergic antidepressants facing cr...
Blood biomarker changes and relationships after low dose oral ketamine treatment for post-traumatic stress disorder (PTSD)
Blood biomarker changes and relationships after low dose oral ketamine treatment for post-traumatic stress disorder (PTSD)
Ketamine has been investigated as a treatment alternative for PTSD for the last 20 years, yet there have been limited repo...
The effects of reward uncertainty and alcohol intoxication on human sign- and goal-tracking
The effects of reward uncertainty and alcohol intoxication on human sign- and goal-tracking
Sign- and goal-tracking (ST/GT) behaviors capture individual differences in reactivity to reward-predictive cues and are i...
D[His]NPY, an agonist of NPY receptor 1, averts traumatic stress-induced behavioral deficits in male and female rats
D[His]NPY, an agonist of NPY receptor 1, averts traumatic stress-induced behavioral deficits in male and female rats
Neuropeptide Y (NPY) has emerged as a key modulator of stress resilience, primarily through activation of the Y1 receptor ...
Xylazine exacerbates fentanyl-induced respiratory depression and prevents rescue by naloxone in mice
Xylazine exacerbates fentanyl-induced respiratory depression and prevents rescue by naloxone in mice
Xylazine is a veterinary sedative and widespread adulterant of illicit opioids, where it is commonly detected in combinati...
Integrated stress response inhibition rescues inflammation-associated accelerated forgetting of recognition memory in mice
Integrated stress response inhibition rescues inflammation-associated accelerated forgetting of recognition memory in mice
Accelerated forgetting contributes substantially to memory deterioration in various neurological disorders in which inflam...
Chronic semaglutide treatment enhances the incentive motivational value of a small food reward and associated cue in male and female rats
Chronic semaglutide treatment enhances the incentive motivational value of a small food reward and associated cue in male and female rats
Glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide, are increasingly utilized in clinical practice due...
Dual hypocretin receptor antagonists enhance sleep and nursing behavior in lactating rats
Dual hypocretin receptor antagonists enhance sleep and nursing behavior in lactating rats
Hypocretins (also known as orexins) are neuropeptides that regulate the sleep–wake cycle and modulate a variety of b...
Schaftoside inhibits neuroinflammation and exerts antidepressant effects through METTL3-mediated m6A modification of circ_0001470 sponging miR-183-5p to regulate MAP3K1 expression
Schaftoside inhibits neuroinflammation and exerts antidepressant effects through METTL3-mediated m6A modification of circ_0001470 sponging miR-183-5p to regulate MAP3K1 expression
Major depressive disorder (MDD) involves neuroinflammation and dysregulation of non-coding RNAs ; however, effective targe...
High incidence of estrous cycle irregularities in heterogeneous stock (HS) rats is associated with footshock-resistant cocaine intake
High incidence of estrous cycle irregularities in heterogeneous stock (HS) rats is associated with footshock-resistant cocaine intake
Hormonal fluctuations throughout the estrous cycle are hypothesized to influence drug-related behaviors. Preclinical model...
96-h methamphetamine self-administration elicits striatal dopamine depletion in male and female rats: a model of binge-like use
96-h methamphetamine self-administration elicits striatal dopamine depletion in male and female rats: a model of binge-like use
Methamphetamine is a psychostimulant with significant public health implications. Chronic methamphetamine use is linked to...
Effects of acute alcohol administration on endocannabinoids and relation to subjective effects
Effects of acute alcohol administration on endocannabinoids and relation to subjective effects
Harmful alcohol use remains a significant global public health challenge. Examining variability in the acute subjective ef...
ASIC1a channels in the locus coeruleus mediate hypercapnic acidosis detection and CO-induced panic behavior
ASIC1a channels in the locus coeruleus mediate hypercapnic acidosis detection and CO-induced panic behavior
There is a connection between respiratory pathologies and panic disorder, since episodes of hypercapnia can trigger anxiet...
Attentional bias in young adult tobacco cigarette smokers and e-cigarette users: an eye-tracking study
Attentional bias in young adult tobacco cigarette smokers and e-cigarette users: an eye-tracking study
Attentional bias (AB) is a key behavioural feature known to contribute to the maintenance of tobacco use; however, little ...
Effects of selected alkaloids on postnatal neurogenesis - in vivo and in vitro studies - literature review
Effects of selected alkaloids on postnatal neurogenesis - in vivo and in vitro studies - literature review
Postnatal neurogenesis is the process of new nerve cell formation that occurs after birth. The disruption of the neurogene...
Methylphenidate leads to disruptions in rest/wake patterns after discontinuation
Methylphenidate leads to disruptions in rest/wake patterns after discontinuation
Children with attention-deficit/hyperactivity disorder (ADHD) experience more sleep problems than their peers. As stimulan...
Virtual reality environmental enrichment effects on heart rate variability in healthy volunteers
Virtual reality environmental enrichment effects on heart rate variability in healthy volunteers
Environmental enrichment (EE) is a nonpharmacological approach widely used in preclinical studies and only recently applie...
The effects of orally ingested Delta-9-Tetrahydrocannabinol on drivers’ hazard perception and risk-taking behaviours: A within-subjects study of medicinal cannabis users
The effects of orally ingested Delta-9-Tetrahydrocannabinol on drivers’ hazard perception and risk-taking behaviours: A within-subjects study of medicinal cannabis users
Medicinal cannabis use is increasing worldwide, yet its impacts on driving safety in frequent users are not clearly unders...
Effects of naturalistic doses of cannabis edibles on cognition and association with blood THC
Effects of naturalistic doses of cannabis edibles on cognition and association with blood THC
Smoked cannabis is known to have effects on cognitive function. The use of edibles is on the rise yet there are few studie...
Methylphenidate (Ritalin) does not improve exam performance in an experimental setting
Methylphenidate (Ritalin) does not improve exam performance in an experimental setting
Surveys indicate that about 10–20% of students use medicinal drugs to improve their exam performance. Whether these ...
Montelukast attenuated memory decline, neuroinflammatory and neurodegenerative biomarkers in Aβ exposed model of alzheimer’s disease in mice
Montelukast attenuated memory decline, neuroinflammatory and neurodegenerative biomarkers in Aβ exposed model of alzheimer’s disease in mice
Alzheimer’s disease (AD) represents major cognitive and memory decline in the elderly patients. Although Montelukast...
Application of nanomaterials in central nervous system disorders
Application of nanomaterials in central nervous system disorders
There is a common mechanism in the pathogenesis of central nervous system diseases: Neuronal damage causes a dissipation o...
Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human
Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human
Monoamine triple reuptake inhibitors (TRIs) inhibit central dopamine, norepinephrine, and serotonin transporters, restorin...
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