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Novel insights and perspectives for the diagnosis and treatment of hearing loss through the implementation of magnetic nanotheranostics
Novel insights and perspectives for the diagnosis and treatment of hearing loss through the implementation of magnetic nanotheranostics
Hearing loss (HL) is a sensory disability that affects 5% of the world's population. HL predominantly involves damage and ...
Design, synthesis, in vitro and in silico characterization of new 2‐quinolone‐ L ‐alaninate‐1,2,3‐triazoles as novel antimicrobial agents
Design, synthesis, in vitro and in silico characterization of new 2‐quinolone‐ L ‐alaninate‐1,2,3‐triazoles as novel antimicrobial agents
Due to the ever-increasing antimicrobial resistance there is an urgent need to continuously design and develop novel antim...
Selective binding of small molecules to Vibrio cholerae DsbA offers a starting point for the design of novel antibacterials
Selective binding of small molecules to Vibrio cholerae DsbA offers a starting point for the design of novel antibacterials
DsbA enzymes catalyze oxidative folding of proteins that are secreted into the periplasm of Gram-negative bacteria, and th...
Amino‐Acid‐Anthraquinone Click Chemistry Conjugates Selectively Target Human Telomeric G‐Quadruplexes
Amino‐Acid‐Anthraquinone Click Chemistry Conjugates Selectively Target Human Telomeric G‐Quadruplexes
Abstract Guanine-rich sequences are known to fold into G-quadruplex (G4) arrangements, which are present in oncogenes and ...
Drug‐Derived Surface‐Active Ionic Liquids: A Cost‐Effective Way To Expressively Increase the Blood‐Stage Antimalarial Activity of Primaquine
Drug‐Derived Surface‐Active Ionic Liquids: A Cost‐Effective Way To Expressively Increase the Blood‐Stage Antimalarial Activity of Primaquine
Abstract Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, whi...
Ureidosulfocoumarin Derivatives As Selective and Potent Carbonic Anhydrase IX and XII Inhibitors
Ureidosulfocoumarin Derivatives As Selective and Potent Carbonic Anhydrase IX and XII Inhibitors
Abstract Owing to severe allergic reactions (anaphylaxis) and resistance exhibited by sulfonamide-based carbonic anhydrase...
Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis
Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis
Abstract 8-Nitrobenzothiazinones (BTZs) are a promising class of antimycobacterial agents currently under investigation in...
19F MRI Nanotheranostics for Cancer Management: Progress and Prospects
19F MRI Nanotheranostics for Cancer Management: Progress and Prospects
Fluorine magnetic resonance imaging (19F MRI) is a promising imaging technique for cancer diagnosis because of its excelle...
Dihydropyridine Lactam Analogs Targeting BET Bromodomains
Dihydropyridine Lactam Analogs Targeting BET Bromodomains
Abstract Inhibitors of Bromodomain and Extra Terminal (BET) proteins are investigated for various therapeutic indications,...
Convenient Synthesis of Alternatively Bridged Tryptophan Ketopiperazines and their Activities Against Trypanosomatid Parasites
Convenient Synthesis of Alternatively Bridged Tryptophan Ketopiperazines and their Activities Against Trypanosomatid Parasites
There is an urgent need for the development of new treatments against trypanosomatid parasites; the causative agents of so...
Synthesis of Isocryptolepine‐Triazole Adducts and Evaluation of Their Cytotoxic Activity
Synthesis of Isocryptolepine‐Triazole Adducts and Evaluation of Their Cytotoxic Activity
Abstract Eighteen hybrid compounds between 8-bromo-2-fluoro-isocryptolepine (4) and 1,2,3-triazole were synthesized via az...
Front Cover: Towards Imaging Pt Chemoresistance Using Gd(III)‐Pt(II) Theranostic MR Contrast Agents (ChemMedChem 24/2021)
Front Cover: Towards Imaging Pt Chemoresistance Using Gd(III)‐Pt(II) Theranostic MR Contrast Agents (ChemMedChem 24/2021)
The Front Cover illustrates the use of a Gd(III)-Pt(II) theranostic MRI contrast agent for imaging Pt drug accumulation di...
Cover Feature: Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors (ChemMedChem 24/2021)
Cover Feature: Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors (ChemMedChem 24/2021)
The Cover Feature illustrates a microscale parallel synthetic approach leading to novel N-acylated aminotriazoles having a...
Targeting the IspD enzyme in the MEP pathway: identification of a novel fragment class
Targeting the IspD enzyme in the MEP pathway: identification of a novel fragment class
Enzymes of the 2-C-methylerythritol-d-erythritol 4-phosphate 2C-methyl-D-erythritol 4-phosphate (MEP) pathway (MEP pathway...
5’‐Phosphorylation Increases the Efficacy of Nucleoside Inhibitors of the DNA Repair Enzyme SNM1A
5’‐Phosphorylation Increases the Efficacy of Nucleoside Inhibitors of the DNA Repair Enzyme SNM1A
Certain cancers exhibit upregulation of DNA interstrand crosslink repair pathways, which contributes to resistance to cros...
Selective Galectin‐8N Ligands: The Design and Synthesis of Phthalazinone‐d‐Galactals
Selective Galectin‐8N Ligands: The Design and Synthesis of Phthalazinone‐d‐Galactals
Ligand selectivity among the highly conserved galectins has been an ever-challenging objective. For galectin-8, a protein ...
Amino acid‐anthraquinone click chemistry conjugates selectively target human telomeric G‐quadruplex
Amino acid‐anthraquinone click chemistry conjugates selectively target human telomeric G‐quadruplex
Guanine-rich sequences are known to fold into G-quadruplex (G4) arrangements, which are present in oncogenes and in the te...
Drug‐derived surface‐active ionic liquids: a cost‐effective way to expressively increase blood‐stage antimalarial activity of primaquine
Drug‐derived surface‐active ionic liquids: a cost‐effective way to expressively increase blood‐stage antimalarial activity of primaquine
Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displa...
Corrigendum: New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS‐CoV‐2
Corrigendum: New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS‐CoV‐2
Please check your email for instructions on resetting your password. If you do not r...
Movement of Mitochondria with Mutant DNA through Extracellular Vesicles Helps Cancer Cells Acquire Chemoresistance
Movement of Mitochondria with Mutant DNA through Extracellular Vesicles Helps Cancer Cells Acquire Chemoresistance
Abstract Triple negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with the worst progn...
Synthesis and Evaluation of Antioxidant, Anti‐Edematogenic and Antinociceptive Properties of Selenium‐Sulfa Compounds
Synthesis and Evaluation of Antioxidant, Anti‐Edematogenic and Antinociceptive Properties of Selenium‐Sulfa Compounds
Abstract Herein we describe results for the synthesis and synthetic application of 4-amino-3-(arylselenyl)benzenesulfonami...
Intracellular Delivery of Antibodies for Selective Cell Signaling Interference
Intracellular Delivery of Antibodies for Selective Cell Signaling Interference
Many intracellular signaling events remain poorly characterized due to a general lack of tools to interfere with “u...
Novel ureidosulfocoumarin derivatives as selective and potent carbonic anhydrase IX and XII inhibitors: Design, synthesis and biological evaluation
Novel ureidosulfocoumarin derivatives as selective and potent carbonic anhydrase IX and XII inhibitors: Design, synthesis and biological evaluation
Owing to severe allergic reaction (anaphylaxis) and resistance shown by sulfonamide based CA inhibitors, non-classical or ...
Mitochondria‐Targeted Triphenylphosphonium Conjugated C‐3 Modified Betulin: Synthesis, Antitumor Properties and Mechanism of Action
Mitochondria‐Targeted Triphenylphosphonium Conjugated C‐3 Modified Betulin: Synthesis, Antitumor Properties and Mechanism of Action
A series of mitochondria-targeted triphenylphosphonium conjugated C-3 modified betulin were synthesized and evaluated agai...
Sonodynamic Therapy with Metal Complexes: A New Promise in Cancer Therapy
Sonodynamic Therapy with Metal Complexes: A New Promise in Cancer Therapy
Abstract In recent years, to overcome the problem of low tissue penetration power of light in photodynamic therapy (PDT), ...
Evaluation of the correlation between porphyrin accumulation in cancer cells and functional porphyrin positions of the phenyl group
Evaluation of the correlation between porphyrin accumulation in cancer cells and functional porphyrin positions of the phenyl group
Porphyrin selectively shows tumour accumulation and has attracted attention as a carrier molecule of drug delivery system ...
Metal‐Based Aggregation‐Induced Emission Theranostic Systems
Metal‐Based Aggregation‐Induced Emission Theranostic Systems
Abstract Efficient theranostic systems can realize better outcomes in disease treatment because of precise diagnosis and t...
Enhancement of CD8+ T‐Cell‐Mediated Tumor Immunotherapy via Magnetic Hyperthermia
Enhancement of CD8+ T‐Cell‐Mediated Tumor Immunotherapy via Magnetic Hyperthermia
Abstract Magnetic hyperthermia (MHT) uses magnetic iron oxide nanoparticles (MIONs) to irradiate heat when subjected to an...
Front Cover: Bithiazole Inhibitors of Phosphatidylinositol 4‐Kinase (PI4KIIIβ) as Broad‐Spectrum Antivirals Blocking the Replication of SARS‐CoV‐2, Zika Virus, and Human Rhinoviruses (ChemMedChem 23/2021)
Front Cover: Bithiazole Inhibitors of Phosphatidylinositol 4‐Kinase (PI4KIIIβ) as Broad‐Spectrum Antivirals Blocking the Replication of SARS‐CoV‐2, Zika Virus, and Human Rhinoviruses (ChemMedChem 23/2021)
The Front Cover shows bithiazole derivatives acting as broad-spectrum antiviral agents (BSAAs) by targeting human host cel...
Prodrugs of E‐selectin Antagonists with Enhanced Pharmacokinetic Properties
Prodrugs of E‐selectin Antagonists with Enhanced Pharmacokinetic Properties
Abstract Because of their large polar surface area, carbohydrates often exhibit insufficient pharmacokinetic properties. S...
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