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Association between anamorelin therapy and renal function in patients with cancer cachexia: a propensity score–matched retrospective study
Association between anamorelin therapy and renal function in patients with cancer cachexia: a propensity score–matched retrospective study
This study investigated the association between anamorelin (ANAM) treatment and longitudinal changes in renal function in ...
Acetaminophen exposure in an aging population and neurodegenerative outcomes
Acetaminophen exposure in an aging population and neurodegenerative outcomes
The deidentified participant data used in this study are not publicly available because of r...
Severe hyperCKemia after levetiracetam with profound electrolyte disturbances
Severe hyperCKemia after levetiracetam with profound electrolyte disturbances
Competing interests The authors declare no competing intere...
Antimicrobial-induced hyponatremia: pathophysiological mechanisms, implicated agents, and clinical management strategies
Antimicrobial-induced hyponatremia: pathophysiological mechanisms, implicated agents, and clinical management strategies
Hyponatremia is a prevalent and serious electrolyte disorder affecting approximately 20% of hospitalized patients, signifi...
Evaluation of Vancomycin Therapeutic Drug Monitoring Strategies: Pharmacokinetic, Pharmacogenetic, and Clinical Perspectives in a Prospective, Real-World Cohort Study
Evaluation of Vancomycin Therapeutic Drug Monitoring Strategies: Pharmacokinetic, Pharmacogenetic, and Clinical Perspectives in a Prospective, Real-World Cohort Study
Vancomycin therapeutic drug monitoring is essential for optimizing efficacy and reducing the risk of vancomycin-associated...
Efficacy of different pharmacological therapies for diffuse cutaneous systemic sclerosis: a systematic review and network meta-analysis
Efficacy of different pharmacological therapies for diffuse cutaneous systemic sclerosis: a systematic review and network meta-analysis
This study aims to compare the effectiveness of different pharmacological therapies for diffuse cutaneous systemic scleros...
Candidate-gene-based study of CYP3A-related single-nucleotide polymorphisms using 4β-hydroxycholesterol/cholesterol ratio as biomarker in a Japanese cohort
Candidate-gene-based study of CYP3A-related single-nucleotide polymorphisms using 4β-hydroxycholesterol/cholesterol ratio as biomarker in a Japanese cohort
CYP3A4 and CYP3A5 are major drug‑metabolizing enzymes that require electrons supplied by P450 oxidoreductase (POR) f...
The effect of Pemafibrate on glucose metabolism and FGF21: a systematic review and meta-analysisa of randomized controlled trials
The effect of Pemafibrate on glucose metabolism and FGF21: a systematic review and meta-analysisa of randomized controlled trials
Pemafibrate, a selective peroxisome proliferator-activated receptor alpha (PPARα) modulator, has shown potential in i...
A decade of progress in small-cell lung cancer (2015–2025): a narrative review
A decade of progress in small-cell lung cancer (2015–2025): a narrative review
Small-cell lung cancer (SCLC) accounts for 13–15% of lung-cancer diagnoses but nearly one quarter of lung-cancer-rel...
Critical analysis of digitalis glycosides: declining use but increasing poison-center exposure cases for digitoxin
Critical analysis of digitalis glycosides: declining use but increasing poison-center exposure cases for digitoxin
Belonging to one of the oldest drug classes in cardiovascular-medicine, the scientific interest in Na+/K+-ATPase inhibitor...
Efficacy and safety of doravirine/islatravir for the treatment of HIV-1: a systematic review and meta-analysis of randomized controlled trials with GRADE assessment
Efficacy and safety of doravirine/islatravir for the treatment of HIV-1: a systematic review and meta-analysis of randomized controlled trials with GRADE assessment
Two-drug antiretroviral regimens are being investigated as alternatives to standard three-drug therapy for HIV-1. Doraviri...
Detection of intravenous drug physicochemical incompatibilities in clinical practice: e-Harvis compared to reference tools
Detection of intravenous drug physicochemical incompatibilities in clinical practice: e-Harvis compared to reference tools
Physicochemical incompatibilities (PCIs) resulting from the simultaneous intravenous administration of drugs through Y-sit...
The efficacy of letrozole in the medical management of ectopic pregnancy: a systematic review and meta-analysis
The efficacy of letrozole in the medical management of ectopic pregnancy: a systematic review and meta-analysis
This review aimed to assess the efficacy and safety of letrozole, administered either as monotherapy or combined with meth...
Comparing National Health Technology Assessment approaches and the new European Joint Clinical Assessment framework: The case of onco-hematological medicines
Comparing National Health Technology Assessment approaches and the new European Joint Clinical Assessment framework: The case of onco-hematological medicines
To analyze national-level evaluations conducted by selected Health Technology Assessment (HTA) bodies and compare them wit...
Efficacy and safety of Ensitrelvir in COVID-19 patients: a systematic review and meta-analysis with focus on viral clearance and RNA change
Efficacy and safety of Ensitrelvir in COVID-19 patients: a systematic review and meta-analysis with focus on viral clearance and RNA change
Coronavirus Disease (COVID-19), which is caused by SARS-CoV-2 virus, led to a worldwide pandemic in late 2019, thus challe...
A narrative review of the placebo effect: historical roots, current applications, and emerging insights
A narrative review of the placebo effect: historical roots, current applications, and emerging insights
Placebo is a term to define physiologically inactive compounds used in treatment that causes physical and emotional change...
Facilitators and barriers to generic and biosimilar medications in the Middle East and North Africa: insights from physicians and pharmacists—a systematic review
Facilitators and barriers to generic and biosimilar medications in the Middle East and North Africa: insights from physicians and pharmacists—a systematic review
The adoption of generic and biosimilar medications is crucial for improving healthcare accessibility and cost savings in t...
Unveiling cardiovascular and respiratory toxicities with monoclonal antibodies in multiple myeloma: disproportionality analysis from the FDA Adverse Event Reporting System
Unveiling cardiovascular and respiratory toxicities with monoclonal antibodies in multiple myeloma: disproportionality analysis from the FDA Adverse Event Reporting System
Monoclonal antibodies (mAbs) have revolutionized the treatment of multiple myeloma (MM), demonstrating remarkable effectiv...
Influence of cigarette smoking on drugs’ metabolism and effects: a systematic review
Influence of cigarette smoking on drugs’ metabolism and effects: a systematic review
Cigarette smoke continues to be widely used around the world and it contains several substances that can affect the pharma...
Genome-wide association study of direct oral anticoagulants and their relation to bleeding
Genome-wide association study of direct oral anticoagulants and their relation to bleeding
Direct oral anticoagulants (DOACs) are used to prevent and treat thromboembolic events in adults. We aimed to investigate ...
Exploring the comprehensive factors influencing tacrolimus pharmacokinetics in early renal transplant recipients: A population pharmacokinetic analysis
Exploring the comprehensive factors influencing tacrolimus pharmacokinetics in early renal transplant recipients: A population pharmacokinetic analysis
To establish a population pharmacokinetic (PopPK) model of tacrolimus in the early stages after renal transplantation and ...
Psychotropic polypharmacy impairs walking independence in post-stroke patients
Psychotropic polypharmacy impairs walking independence in post-stroke patients
Psychotropic drugs are associated with adverse outcomes in older adults. However, evidence on the effect of psychotropic u...
Effect of dapagliflozin on malignant ventricular arrhythmias in elderly after acute myocardial infarction: a propensity score-matched cohort study
Effect of dapagliflozin on malignant ventricular arrhythmias in elderly after acute myocardial infarction: a propensity score-matched cohort study
This study aims to evaluate the effect of dapagliflozin (DAPA) on malignant ventricular arrhythmias (MVA) after acute myoc...
Effects of oral antidiabetic agents on the renin–angiotensin–aldosterone system
Effects of oral antidiabetic agents on the renin–angiotensin–aldosterone system
The renin-angiotensin-aldosterone system (RAAS) is a vital endocrine system that plays a crucial role in maintaining homeo...
Efficacy and safety of pembrolizumab in the treatment of advanced hepatocellular carcinoma: a systematic review and meta-analysis
Efficacy and safety of pembrolizumab in the treatment of advanced hepatocellular carcinoma: a systematic review and meta-analysis
The efficacy and safety of pembrolizumab in treating advanced hepatocellular carcinoma (HCC) are inconsistent across studi...
A novel physiologically-based pharmacokinetic model to estimate reduced CYP3A4 activity in cancer patients utilizing the neutrophil-to-lymphocyte ratio as an inflammatory marker
A novel physiologically-based pharmacokinetic model to estimate reduced CYP3A4 activity in cancer patients utilizing the neutrophil-to-lymphocyte ratio as an inflammatory marker
In advanced cancer patients the CYP3A4-mediated clearance of drugs is dependent on the severity of inflammation. In a stud...
Efficacy of cyclophosphamide for skin fibrosis in systemic sclerosis: a systematic review and single-arm meta-analysis
Efficacy of cyclophosphamide for skin fibrosis in systemic sclerosis: a systematic review and single-arm meta-analysis
Systemic sclerosis (SSc) is a chronic connective tissue disorder characterized by skin thickening with vascular and viscer...
Correction to: Effectiveness of Macrolides as Add-On Therapy to Beta-Lactams in Community-Acquired Pneumonia: A Meta-Analysis of Randomized Controlled Trials
Correction to: Effectiveness of Macrolides as Add-On Therapy to Beta-Lactams in Community-Acquired Pneumonia: A Meta-Analysis of Randomized Controlled Trials
Correction to: European Journal of Clinical Pharmacology (2025) 81:83–91After the pub...
Drug-related falls: proportion and impact of hospitalizations in geriatric departments on the prescription of fall-risk increasing drugs (FRIDs)
Drug-related falls: proportion and impact of hospitalizations in geriatric departments on the prescription of fall-risk increasing drugs (FRIDs)
The incidence of drug-related admissions in France was 8.5% in 2018, with falls being the 5 th cause of DRA. The scr...
Analysis of a medication discrepancy management platform in reducing medication discrepancy and influencing factors among elderly patients with polypharmacy
Analysis of a medication discrepancy management platform in reducing medication discrepancy and influencing factors among elderly patients with polypharmacy
This study aimed to investigate the impact of a medication discrepancy management platform on reducing medication discrepa...
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