SCI Abstract

search
+
Optimization and aerodynamic performance of nebulizable pirfenidone-loaded human serum albumin nanoparticles for targeted pulmonary delivery
Idiopathic pulmonary fibrosis (IPF) is a severe fibrotic lung disease associated with poor survival and limited therapeuti...
The top-down Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models open a new avenue for early drug development
We explored the use of top-down Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models in early drug developmen...
Hydrogel and oleogel formulation of the decapeptide cetrorelix acetate for nasal administration
An oleogel and a hydrogel formulation were developed for nasal administration of the decapeptide Cetrorelix Acetate (CxAc)...
Experimental and virus-specific drivers of EC50 variability in antiviral assays evaluated using mathematical modeling
The half-maximal effective concentrations (EC50) reported for specific antiviral agents often vary widely across in vitro ...
Predicting and validating surfactant performance in nanocrystal stabilization using multi-criteria decision analysis and solubility parameter modeling
This study presents an integrative experimental and computational framework for the rational stabilizer selection in the t...
Application of modelling of cell monolayer permeation data to generate input parameters compatible with in vitro-in vivo translation of blood-brain-barrier disposition of drugs
Adequate translation of parameters from in vitro experiments to in vivo requires a proper characterisation and mechanistic...
Absorption, distribution, metabolism, excretion and mass balance of ainuovirine, a non-nucleoside reverse transcriptase inhibitor in humans
Volume 220, 1 May 2026, 107471Author links open overlay panel, , , , , , , AbstractThis trial was a phase 1, single-centre...
Calpain inhibition preserves myofilament integrity and prevents vandetanib–induced cardiac dysfunction
Vandetanib is a novel multi-targeted tyrosine kinase inhibitor (TKI) that has demonstrated clinical efficacy in the long-t...
Safety, pharmacokinetics, and pharmacodynamics of GS1-144, a neurokinin-3 receptor antagonist: A randomized phase 1 single and multiple ascending dose and food effect study
GS1–144 is a neurokinin-3 receptor (NK3R) antagonist in development for treating menopausal vasomotor symptoms (VMS). This...
Preclinical evaluation of 89Zr/177Lu-labelled anti-B7-H3 monoclonal antibody for theranostics in B7-H3-positive liver cancer
PurposeLiver cancer ranks among the most common cancers with one of the highest mortalities. However, methods for reliable...
89Zr/177Lu-labeled claudin-6 antibody exhibits effective targeted radiodiagnostic and therapeutic efficacy in gynecological cancers
Claudin 6 (CLDN6) is highly expressed in ovarian cancer (OV) and uterine corpus endometrial cancer (UCEC) but silenced in ...
Glycyl-l-histidyl-l-lysine as a novel co-former in co-amorphous systems: Enhanced aqueous solubility and physical stability
Co-amorphous systems have emerged as a promising strategy to enhance the aqueous solubility of poorly water-soluble drugs....
Chronological age, proton pump inhibitors in older adults, and diabetes in older adults on physicochemical characteristics of contents of the descending duodenum during fasting: An exploratory study
ObjectiveExplore the impact of chronological age, proton pump inhibitors (PPIs) in older adults, and Type II diabetes in o...
Inhalable dry powder formulations of the commercialised form of Deoxyribonuclease I - a dried alternative for the treatment of cystic fibrosis
Cystic fibrosis (CF) is an inherited condition characterised by thick mucus accumulation in the lungs, leading to recurren...
Empowering the pharmaceutical workforce for the digital future
The pharmaceutical industry is undergoing a rapid digital transformation. These changes are reshaping drug substance and d...
Lemon balm-derived nanovesicles restore mitochondrial function and reduce cytokine production in skin fibroblasts under pro-inflammatory conditions
Mitochondrial dysfunction, particularly excessive fission, has been implicated in inflammatory signalling in skin diseases...
Personalized oral drug delivery via FDM 3D printing: Polyvinyl alcohol capsules with tunable release profiles supported by in silico modeling
Three-dimensional (3D) printing by Fused Deposition Modeling (FDM) offers a flexible platform for fabricating personalized...
Microdialysis during in vitro lipolysis explains enhanced permeation of indomethacin from phospholipid-based amorphous solid dispersions
Many new drugs are poorly water-soluble requiring enabling formulations like amorphous solid dispersions or lipid-based fo...
Structurally similar, functionally different: Impact of coformer positional isomerism on co-amorphous enzalutamide
Coamorphization is an attractive approach to modifying the physicochemical properties of drug molecules, especially the so...
Deep eutectic systems as enabling pharmaceutical formulations: mechanisms and applications
New pharmaceutical chemical entities discovered in research often fail in development, due to poor biopharmaceutical perfo...
Beta-endorphin is the key endogenous opioid influencing morphine µ-opioid receptor occupancy in rat hypothalamus: a binding kinetic model analysis
The µ-opioid receptor (µ-OR) is the key target for morphine in the treatment of (chronic) pain. Endogenous opioids at the ...
The influence of solvent composition and process parameters on the particle properties of phytosterols in batch cooling crystallization
Phytosterols, which are utilized in the food, pharmaceutical, and cosmetics industries, are typically produced via a solve...
Peptide drug delivery: Permeation behaviour and intracellular fate of hydrophobic ion pairs in self-emulsifying drug delivery systems
This study aimed to investigate the permeation behaviour and intracellular fate of hydrophobic ion pairs (HIP).HIP were fo...
Transport across membrane meets biophysics to unveil the mechanism of action of a novel gH625 analogue
Cell-penetrating peptides are widely used in drug delivery for their ability to facilitate the transport of nanomaterials ...
In vivo metabolic pathways and tissue distribution of pharmaceutical excipient polysorbate 80 using ultra-high performance liquid chromatography-high resolution mass spectrometry analysis
Polysorbate 80 (PS80) is a pharmaceutical excipient widely used in injectables, antibody drugs and vaccines. Due to comple...
Development of a novel physiologically based biopharmaceutics modeling (PBBM) framework using the open systems pharmacology suite, part 1: in vitro modeling of vericiguat
Physiologically Based Biopharmaceutics Modeling (PBBM) links in vitro solubility and dissolution kinetics of oral drugs to...
Development of a novel physiologically based biopharmaceutics modeling (PBBM) framework using the open systems pharmacology suite, part 2: in vivo pharmacokinetic modeling of vericiguat
This manuscript introduces a novel, free and open-source physiologically based biopharmaceutics modeling (PBBM) workflow t...
In vitro evaluation of drug presence in the upper small intestine when antro-duodenal drug transfer of a highly permeable drug occurs after a high-calorie, high-fat meal
Purpose(1) Design and implement in vitro a novel model for evaluating the presence of highly permeable drugs in the upper ...
Archaeosomal nanocarriers improve pharmacokinetics and bioavailability of vancomycin after oral administration
Vancomycin, a glycopeptide antibiotic, is typically administered intravenously (IV) for severe Gram-positive bacterial inf...
The impact of lipid compositions on siRNA and mRNA lipid nanoparticle performance for pulmonary delivery
Lipid nanoparticles (LNPs) are of significant interest as delivery systems for various RNA therapeutics, not least due to ...
Load More
format_indent_increase