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Persistent NRG1 Type III Overexpression in Spinal Motor Neurons Has No Therapeutic Effect on ALS-Related Pathology in SOD1 Mice
Persistent NRG1 Type III Overexpression in Spinal Motor Neurons Has No Therapeutic Effect on ALS-Related Pathology in SOD1 Mice
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting upper and lower motor neurons (MN...
Intravenous Administration of an AAV9 Vector Ubiquitously Expressing Gene Improved CMT-Like Neuropathy in Mice
Intravenous Administration of an AAV9 Vector Ubiquitously Expressing Gene Improved CMT-Like Neuropathy in Mice
Charcot-Marie-Tooth (CMT) disease, also known as hereditary motor sensory neuropathy, is a group of rare genetically heter...
Correction: Transforming Drug Development for Neurological Disorders: Proceedings from a Multidisease Area Workshop
Correction: Transforming Drug Development for Neurological Disorders: Proceedings from a Multidisease Area Workshop
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which ...
Assessing Sustained B-Cell Depletion and Disease Activity in a French Multiple Sclerosis Cohort Treated by Long-Term IV Anti-CD20 Antibody Therapy
Assessing Sustained B-Cell Depletion and Disease Activity in a French Multiple Sclerosis Cohort Treated by Long-Term IV Anti-CD20 Antibody Therapy
Few studies have investigated sustained B-cell depletion after long-term intravenous (IV) anti-CD20 B-cell depleting thera...
Arterial Glyceryl Trinitrate in Acute Ischemic Stroke After Thrombectomy for Neuroprotection (AGAIN): A Pilot Randomized Controlled Trial
Arterial Glyceryl Trinitrate in Acute Ischemic Stroke After Thrombectomy for Neuroprotection (AGAIN): A Pilot Randomized Controlled Trial
Although endovascular therapy demonstrates robust clinical efficacy in acute ischemic stroke (AIS), not all stroke patient...
Intravenous Administration of an AAV9 Vector Ubiquitously Expressing C1orf194 Gene Improved CMT-Like Neuropathy in C1orf194-/- Mice
Intravenous Administration of an AAV9 Vector Ubiquitously Expressing C1orf194 Gene Improved CMT-Like Neuropathy in C1orf194-/- Mice
Charcot-Marie-Tooth (CMT) disease, also known as hereditary motor sensory neuropathy, is a group of rare genetically heter...
Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor
Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor
Magnetic resonance-guided focused ultrasound (MRgFUS) has brought thalamotomy back to the frontline for essential tremor (...
Retraction Note: Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology
Retraction Note: Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology
Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, P...
Retraction Note: Mechanisms Involved in Superiority of Angiotensin Receptor Blockade over ACE Inhibition in Attenuating Neuropathic Pain Induced in Rats
Retraction Note: Mechanisms Involved in Superiority of Angiotensin Receptor Blockade over ACE Inhibition in Attenuating Neuropathic Pain Induced in Rats
The Editor-in-Chief has retracted this article. After publication, concerns were rais...
Wavelet-Based Bracketing, Time–Frequency Beta Burst Detection: New Insights in Parkinson’s Disease
Wavelet-Based Bracketing, Time–Frequency Beta Burst Detection: New Insights in Parkinson’s Disease
Studies have shown that beta band activity is not tonically elevated but comprises exaggerated phasic bursts of varying du...
Transforming Drug Development for Neurological Disorders: Proceedings from a Multidisease Area Workshop
Transforming Drug Development for Neurological Disorders: Proceedings from a Multidisease Area Workshop
Neurological disorders represent some of the most challenging therapeutic areas for successful drug approvals. The escalat...
Should Age 65 be a cutoff for Primary Progressive Multiple Sclerosis therapy? Real World Data is Critical
Should Age 65 be a cutoff for Primary Progressive Multiple Sclerosis therapy? Real World Data is Critical
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
D1R-5-HT2AR Uncoupling Reduces Depressive Behaviours via HDAC Signalling
D1R-5-HT2AR Uncoupling Reduces Depressive Behaviours via HDAC Signalling
Dopamine and serotonin signalling are associated with major depressive disorder, which is a prevalent life-threatening ill...
Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS
Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neuro...
Optimized Nutrition in Mitochondrial Diseases Correlates with Improved Muscle Fatigue, Strength, and Quality of Life: You Are What You Eat, or Are You?
Optimized Nutrition in Mitochondrial Diseases Correlates with Improved Muscle Fatigue, Strength, and Quality of Life: You Are What You Eat, or Are You?
Saneto RP. Mitochondrial diseases: expanding the diagnosis in the era of genetic testing. J Transl Genet Genom. 2020;4:384...
The Renin Angiotensin System as a Therapeutic Target in Traumatic Brain Injury
The Renin Angiotensin System as a Therapeutic Target in Traumatic Brain Injury
Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological options available beyond sympt...
Recombinant Erythropoietin Induces Oligodendrocyte Progenitor Cell Proliferation After Traumatic Brain Injury and Delayed Hypoxemia
Recombinant Erythropoietin Induces Oligodendrocyte Progenitor Cell Proliferation After Traumatic Brain Injury and Delayed Hypoxemia
Traumatic brain injury (TBI) can result in axonal loss and demyelination, leading to persistent damage in the white matter...
Letter from the Editor-in-Chief: Neurotherapeutics’ Transition to Gold Open Access
Letter from the Editor-in-Chief: Neurotherapeutics’ Transition to Gold Open Access
Beginning with the January 2024 issue, Neurotherapeutics will become a fully Open Acc...
Treating Traumatic Brain Injury with Minocycline
Treating Traumatic Brain Injury with Minocycline
Traumatic brain injury (TBI) results in both rapid and delayed brain damage. The speed, complexity, and persistence of TBI...
Frequency-Dependent Reduction of Cybersickness in Virtual Reality by Transcranial Oscillatory Stimulation of the Vestibular Cortex
Frequency-Dependent Reduction of Cybersickness in Virtual Reality by Transcranial Oscillatory Stimulation of the Vestibular Cortex
Virtual reality (VR) applications are pervasive of everyday life, as in working, medical, and entertainment scenarios. The...
Persistent NRG1 Type III Overexpression in Spinal Motor Neurons Has No Therapeutic Effect on ALS-Related Pathology in SOD1G93A Mice
Persistent NRG1 Type III Overexpression in Spinal Motor Neurons Has No Therapeutic Effect on ALS-Related Pathology in SOD1G93A Mice
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting upper and lower motor neurons (MN...
Paradigm Shift: Multiple Potential Pathways to Neurodegenerative Dementia
Paradigm Shift: Multiple Potential Pathways to Neurodegenerative Dementia
Neurodegenerative dementia can result from multiple underlying abnormalities, including neurotransmitter imbalances, prote...
Optimized Nutrition in Mitochondrial Disease Correlates to Improved Muscle Fatigue, Strength, and Quality of Life
Optimized Nutrition in Mitochondrial Disease Correlates to Improved Muscle Fatigue, Strength, and Quality of Life
We sought to prospectively characterize the nutritional status of adults ≥ 19 years (n =&...
Pharmacotherapy for Traumatic Brain Injury: The Next Generation of Clinical Trials
Pharmacotherapy for Traumatic Brain Injury: The Next Generation of Clinical Trials
Marklund N, Bakshi A, Castelbuono DJ, Conte V, McIntosh TK. Evaluation of pharmacological treatment strategies in traumati...
Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model
Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model
Patients with Lafora disease have a mutation in EPM2A or EPM2B, resulting in dysregulation of glycogen metabolism througho...
Phosphodiesterase-5 (PDE-5) Inhibitors as Therapy for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury
Phosphodiesterase-5 (PDE-5) Inhibitors as Therapy for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury
Multiple phase III randomized controlled trials (RCTs) for pharmacologic interventions in traumatic brain injury (TBI) hav...
Functional Brain Networks to Evaluate Treatment Responses in Parkinson’s Disease
Functional Brain Networks to Evaluate Treatment Responses in Parkinson’s Disease
Network analysis of functional brain scans acquired with [18F]-fluorodeoxyglucose positron emission tomography (FDG PET, t...
Evolving Therapeutic Options for the Treatment of Duchenne Muscular Dystrophy
Evolving Therapeutic Options for the Treatment of Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is the most common childhood form of muscular dystrophy. It is caused by mutations in th...
Application of P7C3 Compounds to Investigating and Treating Acute and Chronic Traumatic Brain Injury
Application of P7C3 Compounds to Investigating and Treating Acute and Chronic Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading worldwide cause of disability, and there are currently no medicines that prevent...
Neurosteroid Receptor Modulators for Treating Traumatic Brain Injury
Neurosteroid Receptor Modulators for Treating Traumatic Brain Injury
Traumatic brain injury (TBI) triggers wide-ranging pathology that impacts multiple biochemical and physiological systems, ...
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