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Quaternized chitosan-coated liposomes enable pH-independent nasal mucoadhesion and a sustained local depot for mometasone furoate
Allergic rhinitis (AR) is a common chronic inflammatory disorder of the nasal mucosa whose prevalence has been rising worl...
L-Alaninium borneol ester flurbiprofenate: a dual-function ionic carrier for enhanced solubility and transdermal delivery
Nonsteroidal anti-inflammatory drugs (NSAIDs) are characterized by poor aqueous solubility, often in the low microgram-per...
Topical application of Clostridium butyricum by an anaerobic hydrogel for accelerated diabetic wound healing through selective bacteria inhibition and ROS scavenging
Diabetic ulcers represent a significant and potentially life-threatening chronic complication of diabetes mellitus [1], [2...
From ascorbic acid to N-acetylcysteine: self-assembled clarithromycin liquid crystals as a new generation of carrier-free antibiotics
In a previous study [1], we reported for the first time the spontaneous formation of a cholesteric liquid crystal (CLC) ar...
From vial to prefilled delivery devices in autoimmune diseases: Exploring the formulation and technological pharmaceutical challenges
The use of medicines in the daily clinical practice and meeting the desired effectiveness is many times dependent upon pat...
Development of long-acting intramuscular vortioxetine pamoate suspensions: Formulation optimization and pharmacokinetic evaluation
Depression, a prevalent mental health disorder with a globally rising incidence, has become a critical public health chall...
Targeting dopamine pathways with hybrid molecules: Emerging outlook for cancer treatment
Cancer remains one of the leading causes of death worldwide [1], despite advancements in diagnostics and treatment. Tradit...
Coincidental dependence of low endotoxin recovery and lipopolysaccharide aggregate size on formulation composition and presence of multivalent cations
Low Endotoxin Recovery (LER) is the loss of ability of the industry-standard lipopolysaccharide (LPS)-detection method, th...
Corrigendum to “DNA vaccination for cervical cancer: Strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system” [Eur. J. Pharm. Biopharm. 127 (2018) 288–297]
Volume 222, May 2026, 115018Author links open overlay panelGrace Cole a, Ahlam A. Ali a, Cian M. McCrudden a, John W. McBr...
Corrigendum to “A triple crosslinked micelle-hydrogel lacrimal implant for localized and prolonged therapy of glaucoma” [Eur. J. Pharm. Biopharm. 185 (2023) 44–54]
Volume 222, May 2026, 115019Author links open overlay panelJingyi Zhao a, Jian Xiong a, Yun Ning a, Jiansong Zhao a, Zhipe...
Corrigendum to “Reflection paper on the APV workshop on in vitro performance testing of topically applied and topically acting substances” [Eur. J. Pharm. Biopharm. 220 (2026) 114971]
Volume 222, May 2026, 115023Author links open overlay panelDominique Lunter a b, Sascha Gorissen c, Michael Herbig b c, Ma...
Optimizing spray-dried liposomes for pulmonary delivery: impact of lipids composition and of drying parameters using experimental design
Liposomes have emerged as highly promising carriers for pulmonary drug delivery, a potential recently highlighted by the U...
Automated microstructural characterization of hydrogels using deep instance segmentation and graph-based agglomerate analysis
The performance and stability of pharmaceutical hydrogels depend on microstructural features such as particle size and agg...
Release of rapamycin from core-multishell nanocarriers topically applied on ex vivo human skin probed by scanning transmission X-ray microscopy
Delivery of rapamycin loaded on core-multishell nanocarriers with different architectures supporting redox-induced drug re...
Incorporating immunostimulatory lipids into lipid nanoparticles: exploring expression and immune responses
Lipid nanoparticles (LNPs) are a well-established platform for mRNA vaccine delivery, offering efficient encapsulation and...
One-step synthesized NIR-responsive polydopamine nanoparticles for synergistic nitric oxide chemotherapy and photothermal therapy against multidrug-resistant bacteria
The rapid proliferation of MDRB has escalated into a critical global health emergency, with the World Health Organization ...
Utilizing large-scale produced exosomes in a hepatocellular carcinoma model as an antigen delivery system
Nanoparticle-based delivery systems are attracting interest for vaccine and immunotherapy applications due to their potent...
Electrospun polylactic acid (PLA)/polycaprolactone (PCL) nanofibrous wound dressings incorporating caffeic acid and gentamicin for antibacterial and antibiofilm applications
Wounds, burns, and trauma-induced lacerations that disrupt the skin’s protective bacterial barrier create favourable envir...
Alginate microcapsules for topical delivery of lavender essential oil: Impact of divalent crosslinkers on release, antibacterial efficacy and biocompatibility
Acne vulgaris, commonly referred to as acne, is a chronic inflammatory skin condition that mainly affects adolescents, wit...
Excipients: New opportunities for complex challenges - USP’s approaches
Excipients are important components of medicines that may constitute up to 90% of the total mass/volume of the drug produc...
Nebulized MSC exosomes promote the transdifferentiation of transitional state cells against acute lung injury through STAT3/Krt8/AQP5 axis
Acute lung injury (ALI) is a common respiratory disease caused by multiple etiologies, and the main clinical manifestation...
Quaternary ammonium-modified dextran: a unique biodegradable mucoadhesive polymer
AimThe present study aims to develop a cationic dextran polymer with improved mucoadhesive properties and high biocompatib...
The impact of ionic excipients on stabilization of enalapril tablets by the formation of alkaline salt “in situ”
The formation of salts from pre-existing substances is an effective method for improving the physicochemical properties of...
3D-printed hydrogel patch for controlled topical release: Gelatin/tannic acid formulation meets additive manufacturing
Prolonged use of protective masks can cause skin issues like rosacea and “maskne,” particularly among healthcare workers. ...
Multimodal in vitro characterization techniques for assessing the adhesion of transdermal patches: A proof-of-concept study
Adhesion is one of the most critical parameters for product quality, efficacy, and safety of transdermal delivery systems ...
Quantifying cross-linking strength in sodium starch glycolate and its impact on tablet disintegration and dissolution
The development of a robust oral solid dosage form requires knowledge of all the sources of variation that could impact th...
Optimization and stability evaluation of a pediatric spironolactone oral suspension: Formulation development and analytical validation
The pharmaceutical industry currently falls short in meeting the pediatric medication requirements, including indications,...
Immunoliposomes – a new therapeutic option to treat SynGAP1-associated epilepsy
The blood–brain barrier (BBB) hinders the uptake of most drugs into the brain. Thus, active processes, physiologically nec...
Stimuli-sensitive hyaluronic acid hydrogels for localized and controlled release of antibodies
Stimuli-sensitive hydrogels are utilized in therapeutic applications for their ability to function as controlled drug deli...
Sprayable thermosensitive in-situ gels loaded with apoptotic body-integrated nanozymes for improved diabetic wound healing
Research indicates that 19–34 % of diabetic patients are at risk of developing foot infections, which may progress to intr...
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