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The correlation between characteristics and pharmacological effects of monoterpene glycosides and tannins in Radix Paeoniae Alba
The pharmacodynamic material basis constitutes the central element of traditional Chinese medicine (TCM) in disease treatm...
Recent advances in the analysis of unsaturated fatty acids in biological samples based on chemical derivatization and mass spectrometry techniques
Volume 16, Issue 3, March 2026, 101491Author links open overlay panel, , , , , , , Highlights•Derivatization of carboxyl g...
Development and validation of a static multiple light scattering (SMLS) method for real-time colloidal stability assessment in nanoparticle formulations
This study presents the first development and validation of a static multiple light scattering (SMLS)-based method for rea...
Metabolic heterogeneity, networks, and biomarkers of drug-induced liver injury
Drug-induced liver injury (DILI) represents a major adverse drug reaction with significant clinical implications. The dive...
Equivariant graph neural network-based accurate and ultra-fast virtual screening of small molecules targeting miRNA-protein complex
Volume 16, Issue 3, March 2026, 101339Author links open overlay panelHuabei Wang, Zhimin Zhang, Guangyang Zhang, Ming Wen,...
A novel proteolysis-targeting chimera strategy targeting multiple immune checkpoints containing ITIMs enhances antitumor immunity
Volume 16, Issue 3, March 2026, 101511Author links open overlay panel, , , , , , , , , , , , Highlights•PITIP increased CD...
MST4 as a key driver of osteoclast activation in osteoporosis
Volume 16, Issue 3, March 2026, 101401Author links open overlay panel, , , Highlights•This study reveals a novel mechanism...
Feature-based molecular networking and building blocks identification advance novel natural products characterization: Sesquiterpene-chromone hybrids in agarwood as an application
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Corrigendum to “ACtriplet: An improved deep learning model for activity cliffs prediction by integrating triplet loss and pre-training” [J. Pharm. Anal., 15 (2025) 101317]
Volume 16, Issue 3, March 2026, 101604Author links open overlay panelXinxin Yu, Yimeng Wang, Long Chen, Weihua Li, Yun Tan...
Unraveling the mechanism of Lianqiaobaidu powder in viral myocarditis: Complementary actions within cardiac cell types
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Integrating mass spectrometry imaging and data-driven segmentation for spatial metabolic mapping of diabetic eye disease
Diabetic eye disease (DED) is a leading cause of vision impairment worldwide, yet the molecular mechanisms underlying its ...
Arctigenin Discoverd by High-throughput Screening Ameliorates Doxorubicin-Induced Cardiotoxicity as a Novel Natural KEAP1-NRF2 Inhibitor
Doxorubicin (DOX), a widely used chemotherapeutic, is significantly limited by dose-dependent cardiotoxicity characterized...
DT-TRAP enables accurate target recognition via simplified dosing and low-temperature incubation
Target-responsive accessibility profiling (TRAP) is a powerful chemoproteomic strategy for drug target discovery that moni...
Rapid and Sensitive Screening of Carbonic Anhydrase Natural Inhibitors in Traditional Chinese Medicine via a Carbon Quantum Dot-Affinity Adsorption Nanosystem
The advancement of carbonic anhydrase (CA) activity and its inhibitor assays is crucial for drug development. Screening ef...
Standardizing pre-existing anti-PEG antibody detection: A key to clarifying their binding features and clinical relevance
Available online 17 March 2026, 101609Author links open overlay panel, , , , , , , Highlights•determining the appropriate ...
Mifepristone ameliorates osteoporosis & hyperlipidemia comorbidity through SPNS3-S1P-S1PR1 axis via regulating BMSCs differentiation
Available online 19 March 2026, 101608Author links open overlay panel, , , , , , , Research Highlights●SPNS3-S1P (sphingos...
Bifidobacterium pseudolongum enriched by arctigenin orchestrates cough variant asthma via the acetate-aryl hydrocarbon receptor-interleukin-33 axis
Gut microbiota dysbiosis is significantly associated with the onset and progression of cough variant asthma (CVA). Targeti...
Clarifying the active ingredients & pharmacological mechanisms of traditional Chinese medicines via modern pharmaceutical analysis techniques
Available online 24 March 2026, 101611Author links open overlay panel, , , , , , , , Highlights•Proposes a framework for c...
In situ construction of an SPR biosensor using cell-free protein synthesis technology and its application in drug screening for CXCR4
Available online 24 March 2026, 101613Author links open overlay panel, , , , , , , , , , , Highlights•CFPS technology was ...
Aptamer-based nanoparticle drug delivery system designed for targeting GPC3-positive liver cancer
Available online 24 March 2026, 101614Author links open overlay panel, , , , , , , Highlights•Novel Nanoparticle Drug Deli...
Innovative perspective on the geographical origin and quality of Peucedanum praeruptorum Dunn through the integration of inorganic and organic substance profiles
The clinical efficacy of traditional Chinese medicines (TCMs) is closely linked to their genuine quality. Identifying the ...
Intestinal anti-inflammatory drug targets as potential modifiers of cardiovascular disease risk
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Apatinib and silver nanoparticles synergize against gastric cancer through the PI3K/Akt signaling pathway-mediated ferroptosis
HA-Ag-PLGA@Apa NPs demonstrated a synergistic effect in tumor eradication with favorable targeting abilities, and can effe...
Unlocking Wnt’s Weak Spot: Glycosylated Nanoalbumins to Reignite Immune Responses in MSS-CRC
Available online 24 July 2025, 101412Author links open overlay panel, , , , , , , , , Highlights•Developing a novel therap...
HyPepTox-Fuse: An interpretable hybrid framework for accurate peptide toxicity prediction fusing protein language model-based embeddings with conventional descriptors
Available online 24 July 2025, 101410Author links open overlay panelDuong Thanh Tran a 1, Nhat Truong Pham a 1, Nguyen Doa...
Unveiling optimal molecular features for hERG insights with automatic machine learning
We developed MaxQsaring, a novel universal framework integrating molecular descriptors, fingerprints, and deep-learning pr...
A comprehensive review of Intelligent Question-Answering Systems in Traditional Chinese Medicine Based on LLMs
Large language models (LLMs) are advanced deep learning models with billions or even trillions of parameters, enabling pow...
Therapeutic strategies based on macrophages and their derivatives: Targeted drug delivery platforms and disease treatment
In addition to summarizing recent advancements, the review critically discusses key challenges in MDDS development, such a...
Studies and Analysis of Drug-Target Interactions by Affinity Chromatography and Related Techniques: A Review
Available online 24 July 2025, 101407Author links open overlay panel, , , , , , , Highlights•Affinity chromatography can b...
Gliquidone alleviates DSS-induced ulcerative colitis in rats by targeting carnitine palmitoyltransferase 1A
Available online 24 July 2025, 101409Author links open overlay panel, , , , , , , , Highlights•CPT1A-mediated LCACs metabo...
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