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Lafutidine Ameliorates Indomethacin-Induced Small Intestinal Damage in Rats by Modifying the Intestinal Mucosal Barrier, Inflammation, and Microbiota

Introduction: Nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal d...

Pharmacology

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Oncostatin M and Nivolumab Affect the Cytotoxic T-Cell Proportions and the Susceptibility to TRAIL-Induced Death in Non-Leukocyte Cell Subpopulations in Soft Tissue Sarcomas

Introduction: Soft tissue sarcomas (STSs) are malignant tumors arising from mesenchy...

Pharmacology

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Research Progress on the Anticancer Molecular Mechanism of Targets Regulating Cell Autophagy

Background: Autophagy is a lysosome-mediated catabolic process that maintains cell h...

Pharmacology

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Dantrolene Significantly Improves Cerebral Blood Flow in a Rat Model of Hemorrhagic Vasospasms

Introduction: A cerebral vasospasm (CVSP) is a potent vasoconstriction of the cerebr...

Pharmacology

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Cardiometabolic Risk Factors in Atorvastatin-Treated Women with Euthyroid Autoimmune Thyroiditis

Introduction: Autoimmune thyroiditis seems to be associated with increased cardiomet...

Pharmacology

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Rosuvastatin Potentiates Gonadotropin-Lowering Effects of Metformin in Postmenopausal Women: A Pilot Study

Introduction: Metformin reduces elevated levels of FSH and LH. In some studies, gona...

Pharmacology

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Alkaloids in Withania somnifera (L.) Dunal Root Extract Contribute to Its Anti-Inflammatory Activity

The anti-inflammatory properties of the medicinal plant Withania somnifera (L.) Dunal (WS) are generall...

Pharmacology

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Myo-Inositol Potentiates the Inhibitory Effect of Metformin on Prolactin Levels

Introduction: Metformin was found to reduce elevated levels of anterior pituitary ho...

Pharmacology

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Experimental Investigations of Monomethyl and Dimethyl Fumarate in an Astrocyte-Microglia Co-Culture Model of Inflammation

Introduction: Multiple sclerosis (MS) is the most common chronic inflammatory, demye...

Pharmacology

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Melatonin Supports the Survival of Cholinergic Neurons in Organotypic Brain Slices of the Basal Nucleus of Meynert

The nucleus basalis of Meynert (nBM) is the major source of cholinergic neurons in the basal forebrain, which require nerv...

Pharmacology

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DPP4 Inhibitor Sitagliptin Reduces Inflammatory Responses and Mast Cell Activation in Allergic Rhinitis

Introduction: DPP4 is thought to be involved in certain immune processes and plays a...

Pharmacology

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Modulation of Neutrophil Function by Recombinant Human IgG1 Fc Hexamer in the Endogenous K/BxN Mouse Model of Rheumatoid Arthritis

Introduction: Neutrophils are a pivotal cell type in the K/BxN mouse model of rheuma...

Pharmacology

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The Aryl Hydrocarbon Receptor Ligand 6-Formylindolo(3,2-b)carbazole Promotes Estrogen Receptor Alpha and c-Fos Protein Degradation and Inhibits MCF-7 Cell Proliferation and Migration

Introduction: Worldwide, breast cancer is the most common cancer in women and is the...

Pharmacology

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Metformin’s Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review

Introduction: Metformin-treated patients may experience severe hyperlactatemia or la...

Pharmacology

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Comparative Efficacy and Safety of Thrombolytic Agents for Pulmonary Embolism: A Bayesian Network Meta-Analysis

Background: Thrombolytic agents and anticoagulants are the two classes of medication...

Pharmacology

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Propofol Inhibits Biological Function of Hepatocellular Carcinoma Cells through LINC00475-Mediated Sonic Hedgehog Pathway

Introduction: Hepatocellular carcinoma (HCC) is the most deadly cancer. Many signal ...

Pharmacology

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Inhibition of Kv7/M Channel Currents by Fangchinoline

Introduction: Voltage-gated Kv7/M potassium channels play an essential role in the c...

Pharmacology

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Oral Administration of Artemisia argyi Polysaccharide Increases Estrogen Level and Maintains Blood Lipid Homeostasis in Ovariectomized Rats

Introduction: Artemisia argyi polysaccharide (AAP) has a benefici...

Pharmacology

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Optimal Antithrombotic Regimen in Left Atrial Appendage Occlusion: The Gordian Knot?

Percutaneous left atrial appendage occlusion (LAAO) is an option to reduce the risk of stroke in patients with atrial fibr...

Pharmacology

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Radioprotective Effect of Zinc Nanoparticles on Ionizing Radiation-induced Nephrotoxicity in Mice

Introduction: Ionizing radiation (IR) causes oxidative stress in kidneys and subsequ...

Pharmacology

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Osimertinib in the Treatment of EGFR Mutation-Positive Advanced Non-Small Cell Lung Cancer: A Meta-Analysis

Background: Non-small cell lung cancer (NSCLC) accounts for about 85% of generally r...

Pharmacology

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High On-Treatment Platelet Reactivity: Aspirin versus Clopidogrel

Background: Antithrombotic regimen in patients on oral anticoagulation (OAC) post-pe...

Pharmacology

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Contents Vol. 107, 2022

Pharmacology...

Pharmacology

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Novel Treatment Options in Metastatic Esophageal Carcinoma: Checkpoint Inhibitors in Combination Therapies

Background: Metastatic esophageal carcinoma (EC) has a poor prognosis and only limit...

Pharmacology

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Protective Effects and Mechanisms of Flavonoids in Renal Ischemia-Reperfusion Injury

Background: Acute kidney injury (AKI) is a common and potentially fatal complication...

Pharmacology

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Factors Associated with Potentially Inappropriate Prescribing in Patients on Peritoneal Dialysis

Introduction: Inappropriate prescribing is common in patients with end-stage kidney ...

Pharmacology

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Astragaloside IV Alleviates Atorvastatin-Induced Hepatotoxicity via AMPK/SIRT1 Pathway

Introduction: Atorvastatin (ATO) is often used to reduce blood lipids and prevent at...

Pharmacology

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Radioprotective Effect of Zinc Nanoparticles on Ionizing Radiation-Induced Nephrotoxicity in Miceds

Introduction: Ionizing radiation (IR) causes oxidative stress in kidneys and subsequ...

Pharmacology

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Luteolin Attenuates Diabetic Myocardial Hypertrophy by Inhibiting Proteasome Activity

Introduction: Luteolin is a flavonoid polyphenolic compound exerting broad pharmacol...

Pharmacology

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LncRNA DDX11-AS1 Promotes Chemoresistance through LIN28A-Mediated ATG12 mRNA Stabilization in Breast Cancer

Introduction: During breast cancer chemotherapy, the chemoresistance that frequently...

Pharmacology

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