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Toxicity assessment of gelsenicine and the search for effective antidotes
Toxicity assessment of gelsenicine and the search for effective antidotes
BackgroundGelsenicine, one of the most toxic alkaloids of Gelsemium elegans Benth (G. elegans), causes severe respiratory ...
Oxidative stress and biochemical indicators in blood of patients addicted to alcohol treated for acute ethylene glycol poisoning
Oxidative stress and biochemical indicators in blood of patients addicted to alcohol treated for acute ethylene glycol poisoning
Ethylene glycol (EG), in addition to its neurotoxic and nephrotoxic effects, evokes oxidative stress. The aim of this stud...
Circ_0006220 promotes non-small cell lung cancer progression via sponging miR-203-3p and regulating RGS17 expression
Circ_0006220 promotes non-small cell lung cancer progression via sponging miR-203-3p and regulating RGS17 expression
BackgroundLung cancer is the most common malignancy, and its mortality ranks first among malignancies. Non-small cell lung...
Frontal QRS-T angle as a predictive marker for myocardial damage in acute carbon monoxide poisoning
Frontal QRS-T angle as a predictive marker for myocardial damage in acute carbon monoxide poisoning
IntroductionThe present study was undertaken to investigate the prognostic value of the frontal QRS-T angle associated wit...
Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice
Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice
Bleomycin (BL) is a powerful chemotherapy drug that has devastating effects on spermatogenic function and may make cancer ...
Diosgenin inhibits the proliferation of gastric cancer cells via inducing mesoderm posterior 1 down-regulation-mediated alternative reading frame expression
Diosgenin inhibits the proliferation of gastric cancer cells via inducing mesoderm posterior 1 down-regulation-mediated alternative reading frame expression
IntroductionWhether and how mesoderm posterior 1 (MESP1) plays a role in the proliferation of gastric cancer cells remain ...
Epicatechin ameliorative effects on methotrexate-induced hepatotoxicity in mice
Epicatechin ameliorative effects on methotrexate-induced hepatotoxicity in mice
BackgroundDue to the fact that methotrexate is widely used both as an immunosuppressive drug and as a chemotherapy agent, ...
Corrigendum to “The PAD4 inhibitor GSK484 enhances the radiosensitivity of triple-negative breast cancer”
Corrigendum to “The PAD4 inhibitor GSK484 enhances the radiosensitivity of triple-negative breast cancer”
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Pomegranate extract ameliorates renal ischemia/reperfusion injury in rats via suppressing NF-κB pathway
Pomegranate extract ameliorates renal ischemia/reperfusion injury in rats via suppressing NF-κB pathway
Inflammation and oxidative stress are the major pathways involved in ischemia–reperfusion (I/R)-induced renal injury. This...
Effect of nano zinc oxide on proliferation and toxicity of human gingival cells
Effect of nano zinc oxide on proliferation and toxicity of human gingival cells
BackgroundPeriodontal dressing is used to cover the gum surface and protect the wound after periodontal surgery. Nanomater...
Exposure to a “safe” dose of environmental pollutant bisphenol A elevates oxidative stress and modulates vasoactive system in hypertensive rats
Exposure to a “safe” dose of environmental pollutant bisphenol A elevates oxidative stress and modulates vasoactive system in hypertensive rats
Due to the prevalence of hypertension (one of the major risk factors of CVD) in the population, it is necessary to explore...
DAPK1 may be a potential biomarker for arterial aneurysm in clinical treatment and activated inflammation levels in arterial aneurysm through NLRP3 inflammasome by Beclin1
DAPK1 may be a potential biomarker for arterial aneurysm in clinical treatment and activated inflammation levels in arterial aneurysm through NLRP3 inflammasome by Beclin1
BackgroundDeath-associated protein kinase (DAPK1) is one of the positive regulators of apoptosis, and it is widely involve...
Tanshinone IIA improves degranulation of mast cells and allergic rhinitis induced by ovalbumin by inhibiting the PLCγ1/PKC/IP3R pathway
Tanshinone IIA improves degranulation of mast cells and allergic rhinitis induced by ovalbumin by inhibiting the PLCγ1/PKC/IP3R pathway
Allergic rhinitis (AR) is a common allergic inflammatory and chronic reactive disease caused by allergen-induced immunoglo...
Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan–induced paw edema in rats
Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan–induced paw edema in rats
In the present study, it is aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) against acute paw inflamm...
Curcumin and resveratrol inhibit chemoresistance in cisplatin-resistant epithelial ovarian cancer cells via targeting P13K pathway
Curcumin and resveratrol inhibit chemoresistance in cisplatin-resistant epithelial ovarian cancer cells via targeting P13K pathway
Background:The activation of the PI3K/AKT/mTOR pathway has been proved to be associated with survival as well as prolifera...
Effects of larazotide acetate, a tight junction regulator, on the liver and intestinal damage in acute liver failure in rats
Effects of larazotide acetate, a tight junction regulator, on the liver and intestinal damage in acute liver failure in rats
Background and AimThe epithelial cells are the strongest determinants of the physical intestinal barrier. Tight junctions ...
Molecular mechanisms underlying the effect of diacerein on trichloroacetic acid–induced hepatic pre-neoplastic lesions in rats
Molecular mechanisms underlying the effect of diacerein on trichloroacetic acid–induced hepatic pre-neoplastic lesions in rats
Hepatocellular carcinoma (HCC) accounts for more than 5% of all human cancers. Diacerein (DIA), an interleukin (IL)-1β inh...
Idarubicin-induced oxidative stress and apoptosis in cardiomyocytes: An in vitro molecular approach
Idarubicin-induced oxidative stress and apoptosis in cardiomyocytes: An in vitro molecular approach
Idarubicin (IDA) is an anthracycline antibiotic, frequently used for the treatment of various human cancers. In vivo roden...
Effect of curcumin on lung epithelial injury and ferroptosis induced by cigarette smoke
Effect of curcumin on lung epithelial injury and ferroptosis induced by cigarette smoke
Cigarette smoke (CS)-caused ferroptosis was involved in the pathogenesis of COPD, but the role of ferroptosis in lung epit...
Anti-inflammatory secondary metabolites from Scrophularia kotschyana
Anti-inflammatory secondary metabolites from Scrophularia kotschyana
The species belonging to Scrophularia genus grow mainly in Irano-Turanian and Mediterranean regions and have been used as ...
Brominated flame retardant TBPH induced oxidative damage and reduced the expression of memory-related proteins in mice, with no discernable impairment of learning and memory
Brominated flame retardant TBPH induced oxidative damage and reduced the expression of memory-related proteins in mice, with no discernable impairment of learning and memory
Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH) is one of the new brominated flame retardants with adverse neurobehav...
Cytochrome P450 3A5 polymorphism affects the metabolism of sorafenib and its toxicity for hepatocellular carcinoma cells in vitro
Cytochrome P450 3A5 polymorphism affects the metabolism of sorafenib and its toxicity for hepatocellular carcinoma cells in vitro
ObjectiveCytochrome P450 3A5 (CYP3A5) is a highly polymorphic gene and the encoded protein variants differ in catalytic ac...
Erythropoietin alleviates acute lung injury induced by ischemia-reperfusion through blocking p38 MAPK signaling
Erythropoietin alleviates acute lung injury induced by ischemia-reperfusion through blocking p38 MAPK signaling
Erythropoietin (EPO) has antiapoptotic, antioxidative, and anti-inflammatory effects on ischemia tissues and protects agai...
GSTP1 Ile105Val polymorphism among North Indian lung cancer patients treated using monotherapy and poly-pharmacy
GSTP1 Ile105Val polymorphism among North Indian lung cancer patients treated using monotherapy and poly-pharmacy
BackgroundGenetic polymorphism within the P1 isoenzyme of the Glutathione-S-Transferase (GST) family is found to modulate ...
Prognostic factors of acetaminophen exposure in the United States: An analysis of 39,000 patients
Prognostic factors of acetaminophen exposure in the United States: An analysis of 39,000 patients
Acetaminophen is a frequently used over-the-counter or prescribed medication in the United States. Exposure to acetaminoph...
Long non-coding RNA expression in silicosis and MRAK050699 function in epithelial–mesenchymal transition
Long non-coding RNA expression in silicosis and MRAK050699 function in epithelial–mesenchymal transition
Silicosis is a lung fibrotic disease caused by chronic silica exposure. Aberrations in long non-coding RNA (lncRNA) expres...
The exposure levels of phthalates in pregnant women and impact factors of fetal malformation
The exposure levels of phthalates in pregnant women and impact factors of fetal malformation
MethodsUrine samples were collected from 157 women with fetal malformations (case group) and 147 women with normal fetuses...
Triptolide regulates oxidative stress and inflammation leading to hepatotoxicity via inducing CYP2E1
Triptolide regulates oxidative stress and inflammation leading to hepatotoxicity via inducing CYP2E1
Triptolide (TP), the main active compound extracted from medicine—tripterygium wilfordii Hook f. (TWHF). It has anti-tumor...
NAMPT-mediated NAD+ biosynthesis suppresses activation of hepatic stellate cells and protects against CCl4-induced liver fibrosis in mice
NAMPT-mediated NAD+ biosynthesis suppresses activation of hepatic stellate cells and protects against CCl4-induced liver fibrosis in mice
Background: Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in the salvage pathway of mamm...
Sulforaphane suppresses autophagy during the malignant progression of gastric carcinoma via activating miR-4521/PIK3R3 pathway
Sulforaphane suppresses autophagy during the malignant progression of gastric carcinoma via activating miR-4521/PIK3R3 pathway
ObjectiveSulforaphane, which exerts an effective anti-cancer ability, is a phytochemical converted from cruciferous plants...
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