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Tumor-educated platelets: from molecular mechanisms to liquid biopsy and therapeutic applications
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Effect of formulation composition on stability and aerosol performance of respirable high load monoclonal antibody powders
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Predicting the tabletability of binary mixtures from individual powder compaction behavior
Tablets are the most widely used pharmaceutical dosage form, representing over 80% of marketed products, due to their prec...
Modulating meloxicam existing forms in PLGA microspheres to achieve drug sustained release and efficient osteoarthritis treatment
Osteoarthritis (OA) is a degenerative joint disease characterized by global joint dysfunction, including cartilage degrada...
Enhancing glioma therapy via intranasal administration of FOF1-ATPase motor-embedded chromatophore nanorockets
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Shear flow during reciprocal shaking does not disrupt protein films at the solid–liquid interface
Protein aggregation remains a major challenge in biopharmaceutical development, despite extensive efforts to mitigate this...
Multimodal assessment of sedimentation and flocculation in spray-dried injectable peptide suspensions
Understanding sedimentation and flocculation is essential for optimizing the physical stability (i.e., minimizing particle...
The influence of drug loading on dissolution behaviours and stability of surfactant-containing amorphous solid dispersions
Poor aqueous solubility predisposes an increasing number of active pharmaceutical ingredients (APIs) to low bioavailabilit...
Fractional ablative laser-enhanced transdermal delivery of vismodegib: systematic evaluation of microporation parameters and permeation kinetics
Basal cell carcinomas (BCCs) are the most prominent type of skin cancer in humans (Dika et al., 2020, Leiter et al., 2020,...
A QbD-informed study of permeation enhancer–octreotide nanoscale interactions influencing performance in pullulan buccal films
The peptide, octreotide, is used to treat acromegaly and neuroendocrine tumours. It is administered by either a long-actin...
Hydroxypropyl-β-cyclodextrin as a multifunctional excipient for enhancing stability and aerosol performance of spray-dried protein formulations
Protein-based drugs are precise therapeutic options for various refractory lung diseases, significantly improving patient ...
Systematic evaluation and hepatic targeting of a dual-fluorescence icaritin microemulsion: elucidating the protein corona-mediated delivery mechanism
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Optimization of drug diffusion in drug-eluting stents for coronary artery based on deep reinforcement learning
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Translating in vitro buccal permeation to in vivo and whole‑body exposure using in silico cell‑based and physiologically-based pharmacokinetic modelling
Drug delivery via the gastrointestinal tract remains the dominant route for administration of many medicinals. However, wh...
High viscosity microenvironment induces chemoresistance of cancer cells through upregulating P-gp
Cancer remains a major challenge in global healthcare, primarily due to its high incidence rate and complex pathophysiolog...
Tofacitinib citrate nanoemulgel induced repigmentation in vitiligo: Assessment of oxidative stress, protein, immunohistochemistry, and mRNA expressions
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Microfluidic production of silk fibroin nanoparticles: Process optimization and modeling
Silk fibroin is an attractive material for drug delivery due to its biocompatibility, stability, and ability to form nanop...
Flow rate ratio as a key parameter in the microfluidic synthesis of doxorubicin-loaded liposomes
Microfluidic devices offer scalable, reproducible platforms to produce liposomal drug delivery systems. Yet the relationsh...
Injectable biodegradable silica hydrogel depot for dexamethasone delivery in the eye via subconjunctival administration
This preclinical study evaluated feasibility of an injectable biodegradable silica hydrogel depot formulation for subconju...
Predicting in vivo performance of piroxicam and apalutamide drug nanocrystals from in vitro flux measurements combined with in silico modelling
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
In vitro release method development for Onivyde® using Agilent NanoDis® system
Onivyde® (irinotecan liposomal injection) was approved by the U.S. Food and Drug Administration (FDA) in 2015 for the trea...
Preparation and in vitro characterization of inhalable cannabidiol dry powder for treating chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease characterized by chronic bronchitis and emphy...
Development of novel electrospun nanofibers loaded with Levosulpiride and Cannabidiol encapsulated in cyclodextrin-phospholipid inclusion complex for ameliorated treatment of anxiety and depression
Depression and anxiety have become major public health concerns over the last two decades, significantly affecting million...
Exosomes fused liposomes: formulation, stability studies and theranostic evaluation for breast cancer applications
Breast cancer develops whenabnormal breast epithelial cells begin to grow uncontrollably, leading to formation a tumor. Br...
Cargo loading and surface display using enlarged MS2 virus-like particles
MS2 VLPs are produced in E. coli through expression of the MS2 bacteriophage coat protein (CP). This self-assembles into a...
Formulation optimization, in vitro and in vivo correlation, and long-acting analgesic efficacy of dezocine-loaded microspheres overcoming the “quick sand” phenomenon
The evolving emphasis on clinical humanistic care has positioned pain management as a critical component of modern healthc...
Structure-guided dual modification prodrug strategy for optimizing camptothecin delivery in pancreatic cancer chemotherapy
Pancreatic ductal adenocarcinoma (PDAC) is a devastating lethal malignancy, accounting for more than 90 % of pancreatic ca...
Utilizing hydroxypropyl methylcellulose acetate succinate-based amorphous solid dispersions to enhance oral bioavailability and antifibrotic activity of nintedanib
Idiopathic pulmonary fibrosis (IPF) is a type of idiopathic interstitial pneumonia and a chronic pulmonary disease charact...
Nanostructured lipid carriers-loaded dry powder inhaler for pulmonary delivery of amphotericin B in treatment of allergic bronchopulmonary aspergillosis
Allergic Bronchopulmonary Aspergillosis (ABPA) is a disease caused by Aspergillus fumigatus in the respiratory tract. ABPA...
Gemcitabine-loaded ICOS-Fc decorated nanosponges: A new chemo immunotherapy combination against pancreatic cancer
Pancreatic cancer incidence is rising both in Europe (Partyka et al., 2023) and the USA (Siegel et al., 2023), with the lo...
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