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Causality assessment of adverse drug reaction: A narrative review to find the most exhaustive and easy-to-use tool in post-authorization settings
Background: The core motive of pharmacovigilance is the detection and prevention of adverse drug reactions (ADRs), to impr...
Sequential hybrid ablation versus surgical CryoMaze alone for treatment of atrial fibrillation (SurHyb Trial): a protocol of the multicentre randomized controlled trial
Background: Atrial fibrillation is common in patients with structural heart disease who are undergoing cardiac surgery. Su...
In vitro study of Nigella sativa and thymoquinone activity on endothelial activation and monocyte adhesion
Introduction: Thymoquinone (TQ) is one of the bioactive compounds in Nigella sativa (NS). Also known as black seeds/cumin,...
Antioxidant action of xanthine oxidase inhibitor febuxostat protects the liver and blood vasculature in SHRSP5/Dmcr rats
Background: Xanthine oxidase (XO) generates reactive oxygen species during uric acid production. Therefore, XO inhibitors,...
The hepatoprotective effect of Sophora viciifolia fruit extract against acetaminophen-induced liver injury in mice
This research demonstrated the protective effect and possible mechanism of the Sophora viciifolia extract (SVE) against ac...
Experimental study on clinical and morphological determination of the optimal cannula diameter for lipoaspirate harvest from rabbit inguinal fat pad
Determining the most appropriate cannula diameter for lipoaspirate harvesting is important, both in terms of the quality a...
Closed reduction and minimally invasive screw osteosynthesis of Pipkin femoral head fractures
Background: Femoral posterior hip dislocation with associated femoral head fractures (Pipkin fractures) are rare high-ener...
hKLK alleviates myocardial fibrosis in mice with viral myocarditis
Myocardial fibrosis is the most serious complication of viral myocarditis (VMC). This study aimed to investigate the thera...
As a novel anticancer candidate, ether extract of Dendrobium nobile overstimulates cellular protein biosynthesis to induce cell stress and autophagy
Increasing data has confirmed the potential anticancer properties of Dendrobium, a traditional Chinese herb. However, most...
Amaryllidaceae alkaloids in skin cancer management: Photoprotective effect on human keratinocytes and anti-proliferative activity in melanoma cells
Skin cancer has high rates of mortality and therapeutic failure. In this study, to develop a multi-agent strategy for skin...
Effects of oleanolic acid on hair growth in mouse dorsal skin mediated via regulation of inflammatory cytokines
Oleanolic acid (OA) is a pentacyclic triterpenoid with favourable physiological activity. It is widely distributed in more...
Comparison of cardiocerebrovascular disease incidence between angiotensin converting enzyme inhibitor and angiotensin receptor blocker users in a real-world cohort
Background: Both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are known to...
Neuropsychological tests and prediction of dementia in association with the degree of carotid stenosis
This study constitutes a cross sectional analysis of the association between cognitive impairment defined by neuropsycholo...
Topical application of indigo-plant leaves extract enhances healing of skin lesion in an excision wound model in rats
Objectives: This study aims to evaluate the pharmacological role of indigo extract in accelerating the wound healing in a ...
Exenatide prevents statin-related LDL receptor increase and improves insulin secretion in pancreatic beta cells (1.1E7) in a protein kinase A-dependent manner
Statins are primary drugs in the treatment of hyperlipidemias. This group of drugs is known for its beneficial pleiotropic...
Assessment of plasma catecholamines in patients with dysmetabolic iron overload syndrome
Background: Dysmetabolic iron overload syndrome (DIOS) is characterized by hyperferritinemia and normal transferrin satura...
ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents
Background: The ADIPOQ gene encodes a fat-derived protein hormone with a preponderant role in the homeostasis of glucose a...
The use of periodontal membranes in the field of periodontology: spotlight on collagen membranes
Periodontal regenerative techniques are performed to accomplish the restitution of soft and hard teeth-supporting tissues ...
Genetic variation in the ADIPOQ gene and serum adiponectin increase the risk of bladder cancer
Bladder cancer (BC) is the 10th most common cancer worldwide. Genetic studies estimated 30% heritability in BC risk. Adipo...
Effects of 17-β-estradiol released from shape-memory terpolymer rods on sciatic nerve regeneration after injury and repair with chitosan nerve conduit in female rats
The aim of this study was to assess 17-β-estradiol (E2) influence on sciatic nerve regeneration after injury foll...
SARS-CoV-2 vaccination associated venous sinus thrombosis in three patients
Introduction: There is increasing evidence that vaccinations against the severe acquired respiratory syndrome coronavirus ...
Photodynamic therapy in breast cancer treatment
Breast cancer is a serious public problem in modern society. Photodynamic therapy (PDT) is increasingly used in modern med...
Exploring the therapeutic potential of acetonic plant extracts in the healing of skin wounds infected with multidrug resistant pathogens
Open wounds are easily susceptible to infection by multi-drug resistant (MDR) pathogens. The emergence of MDR super bacter...
Heart rate dynamics in the prediction of coronary artery disease and myocardial infarction using artificial neural network and support vector machine
Background: Atherosclerosis leads to coronary artery disease (CAD) and myocardial infarction (MI), a major cause of morbid...
Kilohertz alternating current neuromodulation of the pudendal nerves: effects on the anal canal and anal sphincter in rats
The first two objectives were to establish which stimulation parameters of kilohertz frequency alternating current (KHFAC)...
Rare case of alimentary butylbiphenyl intoxication
Background: Unexpected accidental intoxication by uncommon industrial substances is a rare, but challenging and perilous e...
Overexpression of the miR-143/145 and reduced expression of the let-7 and miR-126 for early lung cancer diagnosis
Introduction: Lung cancer is the leading cause of cancer-related deaths worldwide. For this reason, huge efforts are being...
Exploring the potential of Cinnamomum zeylanicum oil against drug resistant Helicobacter pylori-producing cytotoxic genes
Thirty-one of sixty dyspeptic patients tested positive for Helicobacter pylori colonization in this study, as determined b...
Evaluation of anti-methicillin-resistant Staphylococcus aureus property of zerumbone
Context and objective: Zerumbone has been reported to exert anti-microbial effects, but the mechanism by which the compoun...
Association between interferon-gamma (IFN-γ) gene polymorphisms (+874A/T and +2109A/G), and susceptibility to hepatitis B viral infection (HBV)
Background: Interferon-gamma (IFN-γ) is a chief proinflammatory cytokine with a significant role in the immune re...
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