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Dactylides D and E, two modified 22-membered polyol macrolides isolated from Dactylosporangium aurantiacum
Dactylides D and E, two modified 22-membered polyol macrolides isolated from Dactylosporangium aurantiacum
Two new 22-membered macrolides, dactylide D (1) and dactylide E (2), featuring substituted amino acid or a contiguous dipr...
A new aurodox-family compound from Streptomyces sp. HKIB0009: structure and antibacterial activity
A new aurodox-family compound from Streptomyces sp. HKIB0009: structure and antibacterial activity
A new aurodox-family compound named 2-methyl-10-hydroxy-A83016F (1) and the known aurodox (2) were isolated from the Strep...
Four new hydroxyl fatty acids, gambaoic acids A-C and gambaoic B methyl ester, from Shrimp Jeotgal-derived Bacillus sp. SNB-066
Four new hydroxyl fatty acids, gambaoic acids A-C and gambaoic B methyl ester, from Shrimp Jeotgal-derived Bacillus sp. SNB-066
Four new hydroxyl fatty acids (HFAs), gambaoic acids A − C (1 − 3) and gambaoic B meth...
Comparative activity of sulbactam and sulbactam/durlobactam against carbapenem-resistant A. baumannii isolates producing OXA-23 or OXA-23 plus PER-1 enzymes
Comparative activity of sulbactam and sulbactam/durlobactam against carbapenem-resistant A. baumannii isolates producing OXA-23 or OXA-23 plus PER-1 enzymes
Our objective was to compare the in vitro activity of sulbactam and sulbactam/durlobactam against carbapenem-resistant A. ...
Tuspetinib enhances the activity of polymyxin B by inhibiting the GlcNAc6P deacetylase
Tuspetinib enhances the activity of polymyxin B by inhibiting the GlcNAc6P deacetylase
The past decade has witnessed the recognition of antibiotic resistance as an emerging threat to public health. Polymyxin B...
(+)-BE-7585A and its derhodinosyl derivative, two cytotoxic 2-thiosugar-containing angucyclines, derived from an actinomycete Amycolatopsis sp. JS6
(+)-BE-7585A and its derhodinosyl derivative, two cytotoxic 2-thiosugar-containing angucyclines, derived from an actinomycete Amycolatopsis sp. JS6
(+)-BE-7585A (1) and its derhodinosyl derivative (2), two rare 2-thiosugar-containing angucyclines, together with their bi...
Correction: Four new hydroxyl fatty acids, gambaoic acids A-C and gambaoic B methyl ester, from Shrimp Jeotgal-derived Bacillus sp. SNB-066
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Identification of gymnopilin A10 as an antibacterial agent in Gymnopilus mushrooms and discovery of gymnoprenol B13 from the fruiting bodies of G. orientispectabilis
Identification of gymnopilin A10 as an antibacterial agent in Gymnopilus mushrooms and discovery of gymnoprenol B13 from the fruiting bodies of G. orientispectabilis
Gymnopilus orientispectabilis, a bitter and hallucinogenic mushroom found in East Asia, contains polyisoprenepolyol ester ...
Inhibitors of acetohydroxyacid synthase as promising agents against non-tuberculous mycobacterial diseases
Inhibitors of acetohydroxyacid synthase as promising agents against non-tuberculous mycobacterial diseases
Acetohydroxyacid synthase (AHAS), exclusively present in microorganisms and plants, is a promising target for several herb...
Novobiocin primarily targets ParE in Neisseria gonorrhoeae
Novobiocin primarily targets ParE in Neisseria gonorrhoeae
Multidrug-resistant Neisseria gonorrhoeae is a pathogenic bacterium that poses a public health concern. In this study, we ...
Therapeutic potential of isoallolithocholic acid in methicillin-resistant Staphylococcus Aureus peritoneal infection
Therapeutic potential of isoallolithocholic acid in methicillin-resistant Staphylococcus Aureus peritoneal infection
A significant increase in multidrug-resistant Methicillin-resistant Staphylococcus aureus (MRSA) infections has made it cr...
Activity of cefiderocol in combination with tetracycline analogues against carbapenem-resistant Acinetobacter baumannii
Activity of cefiderocol in combination with tetracycline analogues against carbapenem-resistant Acinetobacter baumannii
Therapeutic options for carbapenem-resistant Acinetobacter baumannii (CA-AB) are quite limited. Cefiderocol, a novel sider...
Winners of the 2023 JA Ōmura Awards for excellence
Winners of the 2023 JA Ōmura Awards for excellence
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional ...
DMR040, a potential antifungal compound
DMR040, a potential antifungal compound
Based on DMR022 [(AEEA-Gly)2-AEEA-amphotericin B methyl ester, AEEA is the abbreviation of 8-amino-3,6-dioxaoctanoic acid]...
Cryptoic acids A and B, benzene-containing polyketides, and cyclocryptamide, a modified diketopiperazine, from an actinomycete of the genus Cryptosporangium
Cryptoic acids A and B, benzene-containing polyketides, and cyclocryptamide, a modified diketopiperazine, from an actinomycete of the genus Cryptosporangium
Two new benzene-containing polyketides, cryptoic acids A (1) and B (2), along with a new acylated diketopiperazine designa...
Aztreonam-avibactam: a new combination with activity against multidrug-resistant Klebsiella pneumoniae complex
Aztreonam-avibactam: a new combination with activity against multidrug-resistant Klebsiella pneumoniae complex
Klebsiella pneumoniae complex (KPc) is a group of opportunistic pathogens that pose a serious threat to public health. Mul...
Anti-microbial efficacy of l-glutaminase (EC 3.5.1.2) against multidrug-resistant Pseudomonas aeruginosa infection
Anti-microbial efficacy of l-glutaminase (EC 3.5.1.2) against multidrug-resistant Pseudomonas aeruginosa infection
The aims of this study were isolation-purification and characterization of l-glutaminase from L. gasseri BRLHM clinical is...
Antimicrobial resistance rates of urogenital Mycoplasma hominis and Ureaplasma species before and during the COVID-19 pandemic: results from a Greek survey, 2014 to 2022
Antimicrobial resistance rates of urogenital Mycoplasma hominis and Ureaplasma species before and during the COVID-19 pandemic: results from a Greek survey, 2014 to 2022
The prevalence of antibiotic-resistant urogenital mycoplasmas and ureaplasmas has been gradually increasing over the years...
Remembering Dr. Shinichi Kondo (15 June 1928–8 October 2022)
Remembering Dr. Shinichi Kondo (15 June 1928–8 October 2022)
Dr. Shinichi Kondo, an Emeritus Member of the Journal of Antibiotics, died on October 8, 2022 at his ...
Chromatin-modifying protein 4C (CHMP4C) affects breast cancer cell growth and doxorubicin resistance as a potential breast cancer therapeutic target
Chromatin-modifying protein 4C (CHMP4C) affects breast cancer cell growth and doxorubicin resistance as a potential breast cancer therapeutic target
Breast cancer (BCa) is one of the common malignancies among women. Doxorubicin (Dox), a type of anthracycline anti-tumor d...
Retraction Note: Molecular docking simulation, drug-likeness assessment, and pharmacokinetic study of some cephalosporin analogues against a penicillin-binding protein of Salmonella typhimurium
Retraction to: The Journal of AntibioticsThe Editor-in-chief has retracted this article because after the publication of t...
Two new adenopeptins B and C inhibit sphere formation of pancreatic cancer cells
Two new adenopeptins B and C inhibit sphere formation of pancreatic cancer cells
Cancer remains one of the leading causes of death worldwide, particularly pancreatic cancer being lethal because of its ag...
Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1
Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1
A set of triterpene A-ring hydroxymethylene-amino-derivatives was synthesized and their antiviral activity was studied. Th...
Catenulopyrizomicins, new anti-Hepatitis B virus compounds, from the rare actinomycete Catenuloplanes sp. MM782L-181F7
Catenulopyrizomicins, new anti-Hepatitis B virus compounds, from the rare actinomycete Catenuloplanes sp. MM782L-181F7
Hepatitis B virus (HBV) causes chronic hepatitis in humans, and current antiviral therapies rarely treat viral infections....
Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis
Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis
Cancer cells including colorectal cancer cells are resistant to anoikis, an anchorage-independent programmed death, which ...
Correction: Antibiotics in the clinical pipeline as of December 2022
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Antiviral potency of lupane and oleanane alkynyl-derivatives against human cytomegalovirus and papillomavirus
Antiviral potency of lupane and oleanane alkynyl-derivatives against human cytomegalovirus and papillomavirus
A library of 18 structurally diverse semisynthetic lupane, oleanane, and ursane types triterpenoids, including C19- or C28...
Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation
Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation
We screened a library of microbial extracts and compounds library using our constructed assay cells and found pulicatins F...
Identification of siderophores blocking infection of Pseudomonas aeruginosa from Kitasatospora sp. LS1784
Identification of siderophores blocking infection of Pseudomonas aeruginosa from Kitasatospora sp. LS1784
Siderophores are low-molecular-mass, high-affinity chelators of Fe3+ ions that are critical for the survival of bacteria i...
Bioactive ambuic acid congeners from endophytic fungus Pestalotiopsis trachicarpicola SC-J551
Bioactive ambuic acid congeners from endophytic fungus Pestalotiopsis trachicarpicola SC-J551
New ambuic acid derivatives, pestallic acids R–V (1−5), together with ambuic acid (6), were isolated from the ...
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