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An integrated metabolome–microbiome analysis revealed distinct regulatory effects of Xiaoer Chiqiao Qingre granules in young versus adult rats with acute upper respiratory tract infection
Xiaoer Chiqiao Qingre Granules (XECQ) is a traditional Chinese medicine (TCM) prescription officially recorded in the Phar...
Danggui Buxue Decoction and its active components alleviate COPD tracheal injury by regulating JAK-STAT pathway and glutathione metabolism in Drosophila and rats
Chronic obstructive pulmonary disease (COPD) continues to be a significant public health concern and an ongoing challenge ...
Safflower washing medicine alleviating acute soft tissue injury via PI3K/Akt pathway
Acute soft tissue injury (ASTI), a common exercise-related condition, significantly impacts health and function. Its core ...
Anticancer mechanisms of Poikilospermum suaveolens root fraction: ethnopharmacological relevance, signaling pathways, and in vitro/in silico studies on MCF-7 cells
Breast cancer is among the most prevalent forms of cancer worldwide, representing a significant cause of morbidity and mor...
Naringin promotes hair regeneration via wnt/β-catenin pathway: A dose-dependent study in C57BL/6J mice
Alopecia, characterized by progressive hair thinning and loss, represents a significant medical and aesthetic concern affe...
OLink proteomic biomarker to predict clinical efficacy of Macaranga sinensis Müll.Arg: A nested case-control study
Volume 361, 24 April 2026, 121243Author links open overlay panel, , , , , Highlights•The clinical application of herbal me...
Levistilide A from Ligusticum chuanxiong alleviates LPS-induced depression- and anxiety-like behaviors by promoting mitophagy through the SIRT3/PINK1/Parkin pathway
Depression is a leading contributor to global mental and physical impairment, and a key component of the global disease bu...
Exploring the effects of Citrus aurantifolia fruits peel essential oil, cultivated in Al-Hasa, in Methotrexate induced kidney and hepatic toxicities: Network Pharmacology, Molecular Docking, and in vivo Experiments
Hasawi lemon, locally termed "Hasawi Lomi," is a regional variety of Citrus aurantiifolia. Cultivated predominantly in the...
Tongmai Yangxin Pill ameliorates doxorubicin-induced cardiotoxicity through m6A/ALKBH5/BNIP3 axis
Doxorubicin (DOX) has been widely used in the treatment of many solid tumors and hematological tumors. However, the widesp...
Mulberry polyphenols (ABRU) promote bone formation and alleviate bone loss via dual regulation of bone metabolism
Bone metabolic homeostasis is essential for maintaining skeletal health. This dynamic balance relies on the finely regulat...
Natural glycosides from Cistanche deserticola alleviate hepatic ischemia–reperfusion injury via a cAMP-mediated signaling pathway
HIRI is a significant clinical complication frequently encountered during liver transplantation, hepatic resection, and ma...
Total flavonoids isolated from Fructus Mume (Prunus mume Sieb. et Zucc.) mitigate Parkinson's disease progression by promoting neuronal mitophagy via activation of the CaMKKβ/AMPK signaling pathway
Parkinson's disease (PD), a widely prevalent and slowly advancing neurodegenerative disorder, impacts over 1 % of individu...
ShenLingBaiZhu powder ameliorates obesity and atherosclerosis by inhibiting inflammation and apoptosis through the suppression of the TLR4/NF-κB pathway
Obesity (OB) and atherosclerosis (AS) represent two major interconnected health crises that collectively impose a substant...
Tianjing Zelan formula improves polycystic ovary syndrome by regulating steroid biosynthesis and arachidonic acid metabolism
Polycystic ovary syndrome (PCOS), affecting 5 %–18 % of women globally (Joham et al., 2022) and approximately 7.8 % in Chi...
Cynomorium Songaricum polysaccharides ameliorate erectile dysfunction through potent inhibition of phosphodiesterase-5
Cynomorium Songaricum (CS), a perennial succulent herb parasitic on the roots of on the roots of Nitraria L species, thriv...
Yangjing Zhongyu decoction ameliorates polycystic ovary syndrome via multi-organ ferroptosis inhibition: A mechanistic study
Polycystic ovary syndrome (PCOS), a prevalent reproductive and endocrine disorder affecting 11–13 % of women globally, is ...
Zhen-Wu-Tang ameliorates renal fibrosis and tissue stiffness in a murine lupus model, an effect associated with the suppression of fibroblast-to-myofibroblast transition
Lupus nephritis (LN) is one of the most common and severe complications of systemic lupus erythematosus (SLE). Approximate...
Bufei formula attenuates airway mucus hypersecretion in COPD through inhibition of TRIM56-mediated ITGB4 ubiquitination
Chronic Obstructive Pulmonary Disease (COPD) is the most prevalent chronic respiratory disorder, marked by persistent resp...
Fujian Tablets promote corticospinal tract remodeling and improve motor function in MCAO rats by regulating BDNF shearing enzyme-mediated proBDNF/mBDNF balance
Ischemic stroke, characterized by sudden interruption of cerebral blood flow, is the leading global cause of disability, a...
MAGED: Multimodal attentive graph learning with gene expression dynamics on knowledge graphs for TCM target prediction
As a traditional medical system with millennia of practical experience, Traditional Chinese Medicine (TCM) has accumulated...
Kudiezi injection attenuates apoptosis and neuroinflammation for ameliorating angiogenesis via miR-21/PDCD4/NF-κB axis in MCAO/reperfusion rats
Stroke ranks as the second leading trigger of mortality worldwide, which is an affliction of human beings (Surojit Paul (2...
Safety evaluation of Areca catechu L. extract powder in rats: acute and 180-day chronic toxicity test
Binglang (Areca catechu L., ARECAE SEMEN), recognized as one of the "Four Major Southern Medicinal Herbs" in China, is pre...
Molecular mechanisms of Potentilla Discolor Bunge in regulating ferroptosis to alleviate DKD via the Nrf2 signaling pathway
According to the 10th edition of the International Diabetes Federation (IDF) diabetes atlas, the incidence of Diabetes Mel...
Corrigendum to “Exploring the mechanism of esculetin extracted from Chroogomphus rutilus in treating liver cancer based on network pharmacology, molecular docking, and in vivo experimental validation” [J. Ethnopharmacol. 348 (2025) 119837–119837]
Volume 350, 26 June 2025, 120005Author links open overlay panelShuang Jiang a b, Haiying Bao a bShow morePrevious article ...
Pharmacological potentials of Rhamnus alaternus L. stem bark extract in vivo: antioxidant, analgesic, anti-inflammatory and wound healing effects
The use of medicinal plants to treat medical issues is common. Over 80 % of Africans, according to the World Health Organi...
Neuroprotection and safety profile of Astragalus membranaceus extract TA-65 in neonatal hypoxic-ischemic brain damage by activating mitochondrial telomerase reverse transcriptase: Evidence from in vitro and in vivo studies
Telomerase reverse transcriptase (TERT) is an essential component of telomerase that plays a significant role in regulatin...
A network pharmacology approach and experimental validation to investigate the protection mechanism of Ganoderma lucidum (Leyss. ex Fr.) Karst spore for acute kidney injury through induction of apoptosis via p53/Caspase 3 signaling pathway
Acute kidney injury (AKI) is a clinical syndrome covering sudden loss of renal function due to retention of urea and other...
Buzhongyiqi granules in ulcerative colitis Therapy: Integrated chemical composition, pharmacodynamic validation, and IL-6/STAT3 axis regulation
Ulcerative colitis (UC) is considered as a global health issue, with a notable surge in incidence over the past two decade...
Fufang zhenzhu tiaozhi capsule alleviates hypothalamic endoplasmic reticulum stress and leptin resistance through autophagy modulation in DIO rats
The development of society and improvements in living standards have led to an increasing prevalence of metabolic diseases...
Inhibition of mitochondrial oxidative stress and apoptosis in the protection of Ginkgo biloba extract 50 against cognitive impairment
Cerebral small vessel disease (CSVD) refers to a series of disorders mainly affecting the small arteries, arterioles, venu...
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