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Therapeutic potential of metal-polyphenol network encapsulated S-nitroso glutathione for difficult-to-treat rhinosinusitis induced by methicillin-resistant Staphylococcus aureus
Chronic rhinosinusitis (CRS) is a persistent inflammatory condition affecting in the sinus mucosa and nasal cavity. It is ...
Minimizing phage stress in poly lactic-co-glycolic acid (PLGA) encapsulation and simplifying production with three-fluid nozzle spray drying
Bacteriophages (phages) have emerged as an alternative to combat multidrug resistant (MDR) infections. Formulating phages ...
Polydopamine-mediated NIR-responsive photothermal/carbon monoxide dual-modal antibacterial catheter coating
Infectious diseases associated with medical devices have always been a great challenge in the medical field, seriously thr...
Study on the preparation of hydroxyethyl cellulose-cryptotanshinone composite films by low-energy electron beam and their sustained release, antibacterial, and anti-inflammatory properties
Inguinal hernia, with its high incidence rate, is primarily treated by surgery, and tension-free repair using a synthetic ...
Biological effects of chlorogenic acid nanoformulations on colorectal cancer cells
The nanoencapsulation of chlorogenic acid (CGA) by nanospray drying was investigated as a protective bioactive delivery st...
Liposome-encapsulated quercetin-MXene-ZIF-8 nanocomposites for targeted breast cancer via chemo-photothermal treatment: Dual-mode therapy enhancement
Female breast cancer (BC) was projected to surpass lung cancer as the most common tumor globally in 2020, with an estimate...
An innovative ciprofloxacin-infused silk hernia mesh for abdominal wall repair and infection control
Abdominal wall hernia (AWH) is the common problem in which internal organs are pushed through a hole in the abdominal wall...
Hyaluobilosomes (hyaluronic acid enriched bilosomes) as novel mucoadhesive prolonged release nanocarriers of felodipine for the treatment of glaucoma
Eyes are considered complex organs with various compartments (cornea, iris, retina, sclera and choroid). Ocular drugs coul...
Transethosomal mucoadhesive intranasal gel as a brain targeting approach for augmenting anti-epileptic efficacy of carabamazepine: Formulation, In vitro evaluation, In vivo biodistribution via radiolabeling technique and In vivo pharmacodynamic evaluation
Epilepsy is a widespread, life-threatening neurological disorder affecting more than 70 million people in the world [1]. I...
Design and optimization of inherently cytotoxic nanostructured lipid carriers as drug vehicles with dual anti-cancer activity
Cancer remains to be one of the most life-threatening diseases with high rates of mortality and morbidity. The major chall...
Computational-guided design and development of resveratrol-loaded liposomes for enhanced stability and therapeutic efficacy
The emergence of sophisticated computational tools, including in silico modeling, molecular docking, and pharmacokinetic s...
Adipose homing peptide-engineered Anti-miR lipodendriplex for exercise mimicry and combating obesity in high-fat diet-induced obese mice
Obesity is a chronic condition characterized by excessive fat accumulation, which disrupts the body's normal physiological...
Development and characterization of hybrid hydrogels derived from decellularized human umbilical cord for tissue engineering applications
The extracellular matrix (ECM) is a three-dimensional network that is found in all tissues and organs and is made up of ma...
Development of hydrogel-based flexible bio-electronic patch: Exogenous electric field and electro-stimulated drug release for accelerated wound healing
Skin is the body's biggest organ, protecting against chemicals, biological agents, and mechanical effects. Skin injuries s...
Dual-targeted polymeric nanoparticles for colon-specific delivery of grape seed extracts: A promising strategy against ulcerative colitis
Ulcerative colitis (UC) is a chronic inflammatory condition that affects the colon and rectum. With a prevalence of 5 mill...
A nanoparticle strategy to repurpose naringenin: Enhancing oral bioavailability via lipid conjugation unlocks potent antituberculosis activity
Tuberculosis (TB) is an infectious disease caused by Mycobacterium Tuberculosis (MTB), which can result in mortality [1]. ...
Investigation of solid-state forms between p-aminosalicylic acid and adenine: Exploring salts, cocrystals and their polymorphism
This study investigates the polymorphic behavior of multi-component adducts formed between p-aminosalicylic acid (PAS), a ...
Mechanistic drug release from cellulose acetate butyrate–palmitic acid-based in situ gels for targeted periodontal therapy via UV–vis imaging
Periodontal disease is a prevalent inflammatory condition that affects the supporting structures of the teeth, leading to ...
Cationic liposomes unlock the potential of ZnPc in antimicrobial photodynamic therapy
Photodynamic therapy (PDT) is a relatively noninvasive therapeutic method for treating several pathologies. PDT involves t...
Biocompatible pickering emulsions stabilized by spirulina protein isolate/A-type gelatin composite particles for enhanced topical delivery
Topical delivery systems have garnered significant interests in dermatological therapeutics and cosmetic applications due ...
Preparation and evaluation of meclinertant-loaded PLGA/chitosan nanoparticles as a potential treatment for non-small cell lung cancer using A549 cells
Lung cancer is one of the most diagnosed type of cancers in the world. The treatment of non-small cell lung cancer (NSCLC)...
Caffeic acid encapsulated 3D printed polycaprolactone/polyvinylpyrrolidone scaffolds for wound healing applications
Wound management is becoming a huge problem throughout the world and it is causing a major effect on the health-care budge...
Transdermal transfersomal hydrogel: A breakthrough in carbamazepine delivery for effective epilepsy management
Epilepsy is a neurological condition marked by irregular electrical activity in the brain [1]. It disrupts central nervous...
Influence of carbon nanotubes on the antimicrobial character of the β-lactam antibiotics Cefepime and Meropenem
Nowadays, multi-drug resistant (MDR) bacteria pose a serious threat to people worldwide [[1], [2], [3], [4]] and very few ...
A design of experiment approach to identify the most stable composition of a ternary co-amorphous system
Ternary co-amorphous systems, comprising a drug, a low molecular weight co-former, and a polymer, are a promising approach...
Gold nanoparticles functionalized with mRNA cap analogs as a strategy to inhibit eIF4E in cancer therapy
Eukaryotic messenger ribonucleic acids (mRNAs) universally exhibit a distinctive modification at their 5′ termini known as...
Preliminary evaluation of the in vitro and in vivo efficacy of a novel nanovesicle-doped nanoemulsion co-loading artemisinin and quercetin as a promising strategy to improve the oral malaria therapy
Since malaria is still a major problem for human health, especially in developing countries, the association of the most e...
Pharmaceutical hybrid nanogel of nano-flavonoid and zinc oxide for dermatological applications
The human skin is initial defense against environmental stressors such as ultraviolet (UV) radiation, pollutants, and path...
Bovine serum albumin-modified prussian blue nanoparticles enhance wound healing through the promotion of skin angiogenesis
Skin wound healing is a multifaceted biological process that encompasses critical stages such as inflammation modulation, ...
Research on the influences of binders on high shear wet granulation and tablet quality
Solid oral dosage forms remain the preferred dosage forms because of their convenience, inexpensive production costs, non-...
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