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Protein Expression in the Gastrocnemius Muscle of a Rodent Shrapnel-Injury Model
Protein Expression in the Gastrocnemius Muscle of a Rodent Shrapnel-Injury Model
With shrapnel injuries, the metal fragment is usually left in place to reduce the risk of morbidity extensive surgery migh...
ACT 2021 Virtual Annual Meeting Poster Abstracts
ACT 2021 Virtual Annual Meeting Poster Abstracts
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Thank You to Our Ad Hoc Reviewers!
Thank You to Our Ad Hoc Reviewers!
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Corrigendum to “Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm”
Corrigendum to “Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm”
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Influences of Unmodified and Carboxylated Carbon Nanotubes on Lipid Profiles in THP-1 Macrophages: A Lipidomics Study
Influences of Unmodified and Carboxylated Carbon Nanotubes on Lipid Profiles in THP-1 Macrophages: A Lipidomics Study
Since the possible roles of surface modifications in determining multi-walled carbon nanotube (MWCNT)–promoted endoplasmic...
Greetings to You in 2022! May We All Have an Amazing Year!
Greetings to You in 2022! May We All Have an Amazing Year!
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Safety Assessment of Citrus Flower- and Leaf-Derived Ingredients as Used in Cosmetics
Safety Assessment of Citrus Flower- and Leaf-Derived Ingredients as Used in Cosmetics
The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 33 Citrus flower- and leaf-derived ingred...
Evaluation of the Expression Profile of Antibiotic-Induced Thrombocytopenia Using the Japanese Adverse Drug Event Report Database
Evaluation of the Expression Profile of Antibiotic-Induced Thrombocytopenia Using the Japanese Adverse Drug Event Report Database
Drug-induced thrombocytopenia (DITP) can be triggered by antibiotics; however, the details remain unclear. Here, we evalua...
Combined Cardiopulmonary Assessments Using Impedance and Digital Implants in Conscious Freely Moving Cynomolgus Monkeys, Beagle Dogs, and Göttingen Minipigs: Pharmacological Characterization and Social Housing Effects
Combined Cardiopulmonary Assessments Using Impedance and Digital Implants in Conscious Freely Moving Cynomolgus Monkeys, Beagle Dogs, and Göttingen Minipigs: Pharmacological Characterization and Social Housing Effects
Respiratory monitoring, using impedance with implanted telemetry in socially housed animals, was not possible until the re...
Apoptotic Effects of a Thioether Analog of Vitamin K3 in a Human Leukemia Cell Line
Apoptotic Effects of a Thioether Analog of Vitamin K3 in a Human Leukemia Cell Line
Research suggests that thioether analogs of vitamin K3 (VK3) can act to preserve the phosphorylation of epidermal growth f...
Current Trends of Practices in Nonclinical Toxicology: An Industry Survey
Current Trends of Practices in Nonclinical Toxicology: An Industry Survey
The growth in drug development over the past years reflects significant advancements in basic sciences and a greater under...
Wood Smoke Extract Promotes Extracellular Matrix Remodeling in Normal Human Lung Fibroblasts
Wood Smoke Extract Promotes Extracellular Matrix Remodeling in Normal Human Lung Fibroblasts
Wood smoke (WS) contains many harmful compounds, including polycyclic aromatic hydrocarbons (PAHs). WS induces inflammatio...
A Review of the Main Considerations for Formulation Development in Preclinical Toxicology Studies
A Review of the Main Considerations for Formulation Development in Preclinical Toxicology Studies
The main considerations for the development of a formulation for preclinical safety assessment testing are explored. Intra...
Metabolomics as a Truly Translational Tool for Precision Medicine
Metabolomics as a Truly Translational Tool for Precision Medicine
Metabolomics is unique among omics technologies in being applicable to metabolism and toxicity studies broadly across orga...
Drug-Induced Seizures: Considerations for Underlying Molecular Mechanisms
Drug-Induced Seizures: Considerations for Underlying Molecular Mechanisms
A broad spectrum of chemical entities have been associated with drug-induced seizure (DIS), emphasizing the importance of ...
Amended Safety Assessment of Acid Violet 43 as Used in Cosmetics
Amended Safety Assessment of Acid Violet 43 as Used in Cosmetics
The Expert Panel for Cosmetic Ingredient Safety (Panel) reopened the safety assessment of Acid Violet 43, a cosmetic ingre...
Safety Assessment of Keratin and Keratin-Derived Ingredients as Used in Cosmetics
Safety Assessment of Keratin and Keratin-Derived Ingredients as Used in Cosmetics
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 8 keratin-derived ingredients, which functi...
Safety Assessment of Saccharide Esters as Used in Cosmetics
Safety Assessment of Saccharide Esters as Used in Cosmetics
This is a safety assessment of 40 saccharide ester ingredients as used in cosmetics. The saccharide esters are reported to...
Safety Assessment of Inorganic Hydroxides as Used in Cosmetics
Safety Assessment of Inorganic Hydroxides as Used in Cosmetics
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of inorganic hydroxides, which function in cos...
Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmetics
Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmetics
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 80 Citrus fruit-derived ingredients, which ...
Safety Assessment of Citrus Plant- and Seed-Derived Ingredients as Used in Cosmetics
Safety Assessment of Citrus Plant- and Seed-Derived Ingredients as Used in Cosmetics
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 30 Citrus plant- and seed-derived ingredien...
Editor’s Response to Jorge A. García-Valenzuela and Martha R. Baez-Gaxiola
Editor’s Response to Jorge A. García-Valenzuela and Martha R. Baez-Gaxiola
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A Health Intersection of Toxicology and Clinical Medicine
A Health Intersection of Toxicology and Clinical Medicine
1. Laterza, OF, Zhao, X. Biomarker discovery, translating molecular biomarkers into clinical assays. In: Weiner, R, Kelley...
Comments on the Risks From Exposure to Denatonium Benzoate (Bitrex®): Denatured Alcohol Disinfection and Pandemic Times
Comments on the Risks From Exposure to Denatonium Benzoate (Bitrex®): Denatured Alcohol Disinfection and Pandemic Times
1. Cosmetic Ingredient Review (CIR) Expert Panel . Final report of the safety assessment of alcohol denat., including SD A...
Safety Assessment of Citrus Peel-Derived Ingredients as Used in Cosmetics
Safety Assessment of Citrus Peel-Derived Ingredients as Used in Cosmetics
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 47 Citrus peel-derived ingredients, which a...
Evaluation of the AV7909 Anthrax Vaccine Toxicity in Sprague Dawley Rats Following Three Intramuscular Administrations
Evaluation of the AV7909 Anthrax Vaccine Toxicity in Sprague Dawley Rats Following Three Intramuscular Administrations
AV7909 is a next-generation anthrax vaccine under development for post-exposure prophylaxis following suspected or confirm...
Effects of Vanadium Inhalation and Sweetened Beverage Ingestion in Mice: Morphological and Biochemical Changes in the Liver
Effects of Vanadium Inhalation and Sweetened Beverage Ingestion in Mice: Morphological and Biochemical Changes in the Liver
The aim of this report was to evaluate the morphological and biochemical changes in the liver by the inhalation of vanadiu...
Four-Week Repeated Intravenous Dose Toxicity of Self-Assembled-Micelle Inhibitory RNA-Targeting Amphiregulin in Mice
Four-Week Repeated Intravenous Dose Toxicity of Self-Assembled-Micelle Inhibitory RNA-Targeting Amphiregulin in Mice
The present study investigated the potential subchronic toxicity of self-assembled-micelle inhibitory RNA-targeting amphir...
Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics
Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics
The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of Methylisothiazolinone, which functions as...
Amended Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone as Used in Cosmetics
Amended Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone as Used in Cosmetics
The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of the mixture Methylchloroisothiazolinone (...
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