SCI Abstract

search
+
Targeting the 4-HNE–H₂S pathway as a therapeutic strategy for placental injury in pregnancy with MAFLD
Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a significant global health challenge. The diagnos...
Silencing PAR-2 in macrophages promotes PANoptosis and triggers duodenal microinflammation in functional dyspepsia
Functional dyspepsia (FD) is a gastrointestinal disorder characterized by digestive symptoms, including upper abdominal pa...
Pyrroloquinoline quinone ameliorates inflammatory responses by modulating macrophage polarization in murine models of SLE and lupus-associated diffuse alveolar hemorrhage
Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease characterized by complex pathogenesis, div...
Camelid-derived antibodies reduce myonecrosis and IL-1β release after treatment with Bothrops jararacussu venom in mice
Snakebite envenoming in Latin America is both an occupational hazard and a neglected tropical disease. Globally, more than...
MAP3K19 promotes the progression of hypopharyngeal cancer by suppressing dendritic cell maturation through mediating NF-κB activation and PD-L1 expression
BackgroundDendritic cells (DCs) infiltration in head and neck tumor tissues correlates with survival, recurrence and metas...
CD44 alleviates myocardial ischemia reperfusion injury through repressing ferroptosis
Acute myocardial infarction (AMI) is a common clinical cardiovascular emergency, which is defined as severe myocardial isc...
Fibroblast-targeted MLN4924 suppresses autoimmune myocarditis by dually modulating IL-17A and TGF-β pathways
Myocarditis is a progressive inflammatory disorder of the myocardium and a significant cause of sudden cardiac death and d...
Decoding mechanisms and therapeutic opportunities in testicular development diseases through macrophage immunology
Volume 172, 1 March 2026, 116242Author links open overlay panelShuang Wu a 1, Dashuai Miao c 1, Jinling Chen b, Wenliang G...
Acetylation of Hint2 mitigates acute liver failure by suppressing neutrophil chemotaxis and NETosis through maintaining mitochondrial calcium and protein homeostasis
Acute liver failure (ALF) is a severe, life-threatening condition triggered by drug toxicity, viral hepatitis, autoimmune ...
The ALKBH1/MYC positive feedback loop regulates TAM polarization and remodels the tumor microenvironment to promote gastric cancer development
Gastric cancer (GC), as one of the deadliest gastrointestinal malignant tumors worldwide, poses a serious threat to the li...
MiR-146a-armed exosomes reverse immunosuppressive networks in NSCLC by dual-targeting of MYD88/STAT3 and PD-L1 axes
Non-small cell lung cancer (NSCLC) comprises over 80 % of all newly diagnosed lung cancer cases globally, and its frequenc...
Therapeutic targeting of the HPV E7 oncoprotein: Current advances and emerging strategies
Cervical cancer is one of the most common malignancies among women, with persistent infection by high-risk human papilloma...
Ginsenoside Rg1 ameliorates depression-like behaviors in mice by inhibiting astrocyte pyroptosis via Cx43-dependent restoration of mitophagy flux
As a traditional tonic Chinese herb, ginseng plays a vital role in the national medicine systems of China, Japan, South Ko...
Lactiplantibacillus plantarum K4–9 strain stimulates antitumor immune responses through the activation of dendritic cells and CD8+ T cells
Antitumor immunity is one of the most critical mechanisms for maintaining health by eliminating tumor cells. Dendritic cel...
Rutin ameliorates hepatic ischemia-reperfusion injury by targeting CD36 to suppress hepatocyte ferroptosis
Liver transplantation, the only curative option for end-stage liver disease, is limited by ischemia-reperfusion injury, wi...
Pterostilbene ameliorates pulmonary fibrogenesis and inflammation targeting IL-23/ATP6V0D2 pathway: remodel local microenvironment of alveolar epithelial cells and fibroblasts
Pulmonary fibrosis is a chronic and progressive lung disease with high morbidity and a median survival of 3–5 years after ...
Antioxidant activity of 2-mercaptoethanol protects against CD8+ T cell overstimulation or accelerated exhaustion: evidence from an in vitro exhausted CD8+ T model and in vivo adoptive cell transfer
Cancers are threatening the health of thousands of people around the world and represent a major cause of death; therefore...
Recent research progress in structural optimization and cancer treatment of novel selective FGFR inhibitors (2020–2025)
Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths (or nearly one in six) in 2020 [1].T...
A novel triazole derivative ameliorates ethanol-induced gastric ulcer via a NOS2-centered inhibition of the AGE-RAGE pathway
Gastric ulcer is a common gastrointestinal condition with substantial worldwide health impacts, characterized by erosions ...
Dihydromyricetin improves DSS-induced colitis and behavioral disorders by regulating the microbiota-gut-brain axis balance and inhibiting the activation of NLRP3 inflammasome
Patients with inflammatory bowel disease (IBD) commonly exhibit psychiatric symptoms, such as anxiety and depression. Howe...
Treatment with senolytic drugs ameliorates steroid-induced osteonecrosis of the femoral head by inhibiting osteoclastogenesis
Osteonecrosis of the femoral head (ONFH) is a disabling orthopedic disease characterized by hyperactivation of osteoclasts...
Artemether ameliorates DSS-induced ulcerative colitis by modulating macrophage polarization
Ulcerative colitis (UC) is a prevalent inflammatory bowel diseases (IBD) characterized by abdominal pain, diarrhea, and re...
A targeted pH-responsive micelle based on poly (ethylene glycol) and polycaprolactone for Pseudomonas aeruginosa pneumonia treatment
Bacterial pneumonia is a globally challenging infectious disease characterized by high incidence and mortality rates [1,2]...
1-O-Acetylbritannilactone exerts anti-inflammatory and anti-MUC5AC effects by targeting PKC-α and downregulating the SRC/EGFR/MAPK signaling pathway
Mucus is an important gel-forming protective layer in the respiratory tract that mainly consists of mucins, among which MU...
Panax notoginseng protects blood-retinal barrier by modulating microglia polarization via TLR4/MyD88/NF-κB pathway in endotoxin-induced uveitis
Uveitis is a kind of inflammatory ocular disease that is the third leading cause of blindness worldwide, accounting for 5–...
Subacute ruminal acidosis induces hepatic injury in dairy goats via oxidative stress and ferritinophagy-ferroptosis axis
With the increasing demand for high-yield dairy production, the industry has widely adopted high-concentrate (HC) diets to...
Mechanistic insights into the limited function of CAR-T cells in solid tumors and potential solutions
Chimeric antigen receptor T (CAR-T) cells represent a novel immunotherapeutic approach that enables cytotoxic T cells to d...
Achievements applications and future of nanomaterials in cancer immunotherapy
Cancer is characterized by abnormal cell proliferation and uncontrolled expansion, leading to a range of devastating disea...
Tumor-associated macrophages in radiotherapy: Mechanisms of polarization, immune regulation and therapeutic strategies
It is an established fact that more than half of cancer patients receive RT, which involves the use of ionizing radiation ...
Pyrazolamide derivative T1 inhibits hepatocellular carcinoma cell proliferation through MAPK pathway modulation
In this study, a novel pyrazole amide derivative designated T1, was designed and synthesized to explore its therapeutic po...
Load More
format_indent_increase