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Metabolic basis of fatty acid oxidation and immunotherapy resistance with clinical perspectives
Volume 84, January 2026, 101317Author links open overlay panel, Section snippetsCRediT authorship contribution statementJu...
Three decades of ESKAPEE antimicrobial resistance: Emerging burdens in working-age individuals and high-income regions
Volume 84, January 2026, 101325Author links open overlay panel, , Section snippetsCRediT authorship contribution statement...
Molecular profiling of chemotherapy-resistant breast cancer reveals DNA methylation remodeling associated with the acquisition of paclitaxel resistance
Available online 2 January 2026, 101350Author links open overlay panel, , , , , , , , , , , , , , , , , , , …Highlights•Ch...
IFNα2b modulates anti-tumor immune responses involving STAT3-associated dendritic cell dysfunction in JAK2v617f-positive myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are clonal hematologic malignancies characterized by excessive proliferation of mature...
Glucocorticoid receptor activated by dexamethasone promotes the chemoresistance and stemness of lung cancer
Siyuan Chen: Writing – review & editing, Formal analysis. Huaicheng Tan: Methodology, Formal analysis, Data curation. ...
Lars2-signaling mediates platinum resistance by accumulating cancer stem cell population and suppressing anti-tumor immunity
Platinum-based chemotherapy remains a cornerstone of cancer treatment; however, its clinical efficacy is frequently compro...
Hyperbaric oxygen targets RCN1 to modulate ER-mitochondria crosstalk and ameliorate sorafenib resistance in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is counted among the top four causes of cancer-associated deaths globally and exhibits a gr...
Entinostat overcomes cisplatin resistance in bladder cancer by promoting H3K18la-mediated DHRS2 expression and nuclear translocation to suppress the AKR1C3-androgen axis
Bladder cancer (BCa) remains a significant cause of cancer-related morbidity and mortality globally (Bray et al., 2024). F...
RCN2 facilitates esophageal squamous cellular carcinoma metastasis and cisplatin resistance through UBR5-mediated PPP2CA ubiquitination and degradation
Esophageal cancer (EC) is the seventh leading cause of cancer-related mortality around the world, with more than 470,000 n...
UBL3 governs VEGFR inhibitor resistance by activating NOTCH signaling in renal cell carcinoma
Volume 85, March 2026, 101332Author links open overlay panel, , , , , , , , , , , , , , , AbstractBackgroundTargeted thera...
DEAF1 confers resistance to adriamycin-induced apoptosis and pyroptosis in multiple myeloma
For newly diagnosed multiple myeloma (MM) patients, the primary treatment approaches include proteasome inhibitors such as...
A tumor-derived lactate/ENO1 lactylation feedback loop facilitates osimertinib resistance of lung adenocarcinoma
Volume 85, March 2026, 101346Author links open overlay panel, , , , , , , , , , , , , AbstractEnhanced glycolysis and lact...
Myeloid immune checkpoint blockade overcomes antibiotic resistance in bone infection by enhancing efferocytosis and suppressing MSC PANoptosis
Bone infection (osteomyelitis) can arise from direct inoculation during trauma or surgery, contiguous spread from adjacent...
Difluoroboron curcumin/glycyrrhizic acid liposome-incorporated Mg²⁺-chelated microgel for MRSA-infected wound photothermal therapy
Cutaneous wounds, especially those complicated by infections with multidrug-resistant pathogens, have posed a formidable c...
Linc01833 drives gemcitabine resistance in non-small cell lung cancer by shielding SLC7A11 from WWP1-mediated ubiquitination and inhibiting ferroptosis
According to the latest global cancer statistics 2022, lung cancer is the leading cause of global cancer mortality, with a...
AMPKα2 attenuates doxorubicin induced ferroptosis by promoting NCOA4 degradation in triple negative breast cancer
Breast cancer (BC) is a prevalent malignancy that significantly impacts women's health. Triple-negative BC (TNBC) accounts...
Single-cell transcriptome analysis of patient-derived organoids captures inter- and intratumor heterogeneity and uncovers targetable pathways in high grade serous ovarian cancer
Volume 85, March 2026, 101354Author links open overlay panel, , , , , , , , , , , , , , AbstractAimHigh grade serous ovari...
Overcoming resistance in oncolytic virotherapy: Nano-engineered solutions for systemic delivery and efficacy boost
Oncolytic virotherapy (OVT) has emerged as a transformative approach in cancer treatment due to its unique capacity for tu...
Mechanisms of resistance to antibody-drug conjugates in breast cancer
Volume 85, March 2026, 101353Author links open overlay panel, , , AbstractAntibody-drug conjugate (ADC) is a drug modality...
Targeting NAT10 attenuates homologous recombination via destabilizing DNA:RNA hybrids and overcomes PARP inhibitor resistance in cancers
Cells are frequently subjected to DNA damage from endogenous and exogenous sources (Awwad et al., 2023, Lord and Ashworth,...
Targeting cTRIP12 counteracts ferroptosis resistance and augments sensitivity to immunotherapy in pancreatic cancer
Volume 81, July 2025, 101240Author links open overlay panel, , , , , , , , , , , , , , , AbstractAimsCurrent therapeutic s...
A quiescence-like/TGF-β1-specific CRISPRi screen reveals drug uptake transporters as secondary targets of kinase inhibitors in AML
Relapse in acute myeloid leukemia (AML) is driven by resistant subclones that survive chemotherapy. It is assumed that the...
KpnK48 clone driving hypervirulent carbapenem-resistant Escherichia coli epidemics: Insights into its evolutionary trajectory similar to Klebsiella pneumoniae
Volume 81, July 2025, 101243Author links open overlay panel, , , , , , , , AbstractAimsHypervirulent and carbapenem-resist...
MVP-LCN2 axis triggers evasion of ferroptosis to drive hepatocarcinogenesis and sorafenib resistance
Liver cancer ranks as the sixth most common type of cancer and the fourth leading cause of cancer-related mortality, with ...
PARP inhibition elicits NK cell-associated immune evasion via potentiating HLA-G expression in tumor
The nuclear enzyme poly(ADP-ribose) polymerase (PARP), in cooperation with homologous recombination repair (HRR), plays a ...
Targeting SLC7A11 with sorafenib sensitizes stereotactic body radiotherapy in colorectal cancer liver metastasis
Colorectal cancer (CRC) is a prevalent and aggressive tumor. Globally, CRC is the third most diagnosed cancer and a leadin...
A novel platinum(IV) prodrug, gramine-Pt(IV) enhances chemoimmunotherapy by activating cGAS-STING and modulating TGF-β-MHC-I axis
Platinum(II) (Pt(II))-based drugs, including cisplatin (CDDP), carboplatin, and oxaliplatin (OXP), have been extensively u...
MicroRNA-mediated PTEN downregulation as a novel non-genetic mechanism of acquired resistance to PI3Kα inhibitors of head & neck squamous cell carcinoma
Volume 81, July 2025, 101251Author links open overlay panel, , , , , , , , , , , , , , , , , , , …AbstractAimsHead and nec...
CSDE1 enhances genotoxic drug resistance in cancer by modulating RPA2 through CSDE1-eIF3a regulatory complex
Volume 81, July 2025, 101249Author links open overlay panel, , , , , , , , , , , , , , , , , , AbstractAimsGenotoxic drug ...
Profiling the landscape of carbapenem resistance and hypervirulence in Klebsiella pneumoniae: A global epidemiological analysis of the plasmidome
Klebsiella pneumoniae is a Gram-negative bacterium that has emerged as a significant opportunistic pathogen responsible fo...
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