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Spatial and multi-omics transcriptomic dissects platinum resistance in lung adenocarcinoma: a five-gene predictive model with tumor microenvironment dynamics
The scarcity of reliable biomarkers and predictive models for platinum resistance in lung adenocarcinoma (LUAD) poses a si...
Integration of network pharmacology, lipidomics, and transcriptomics analysis to reveal the mechanisms underlying the synergy between susceptibility factor TNF-α and Polygonum multiflorum-induced idiosyncratic liver injury in mice
Idiosyncratic Drug-Induced Liver Injury (IDILI) is an adverse drug reaction manifesting exclusively in a limited subset of...
Cinnamic acid induces neurodevelopmental defects via PPARγ signaling in zebrafish
Cinnamic acid (CA), a natural aromatic carboxylic acid, is an organic acid isolated from cinnamon bark, and is characteriz...
Sex-dependent effects of early-life paracetamol exposure on behavior and monoamines in the rat central nervous system
Paracetamol (acetaminophen or para-hydroxyacetanilide) is a widely used over-the-counter analgesic and antipyretic, and al...
Recurrent amoxicillin exposure disrupts colonic homeostasis through oxidative stress, DNA repair dysregulation, and gut dysbiosis-driven inflammation
Antibiotics are essential agents in the treatment of bacterial infections; however, their widespread utilization, includin...
In vitro recapitulation of drug metabolite partitioning into the bile and blood using the icHep system consisting of hepatocytes with an induced open-form bile canaliculus
For in vitro studies that predict the safety of systemically circulating drug metabolites, evaluating the formation and bi...
Molecular mechanisms of Aflatoxin B1-Induced renal injury and the detoxification potential of Taraxasterol: A review
Aflatoxins (AFs) are secondary metabolites produced by toxic strains primarily parasitising Aspergillus flavus and Aspergi...
Cytochrome P450-mediated detoxification and NF-κB/NLRP3 pathway-driven hepatotoxicity of emodin: Multiomics and laboratory evidence
Traditional Chinese Medicine (TCM) is widely recognized for its extensive historical roots and diverse health-promoting pr...
Prenatal hydroxychloroquine exposure-induced morphological and functional changes in multiple organs of fetal mice and its characteristics
A growing body of research confirms that adverse environmental exposures during pregnancy can disrupt normal fetal develop...
ALKBH5-mediated autophagic flux impairment is involved in bilirubin neurotoxicity
Bilirubin-induced brain damage represents a serious clinical consequence of hyperbilirubinemia, yet the role and underlyin...
Resveratrol-induced alterations in selected electrokinetic properties of in vitro models: LN-18 glioma cells and PC liposomes
Naturally occurring bioactive substances possess remarkable therapeutic potential with low toxicity. These compounds play ...
Thalidezine triggers Cathepsin B-mediated cell death in T-cell lymphoma by disrupting lysosomal function
T-cell lymphoma (TCL) includes various aggressive non-Hodgkin lymphomas that develop from T cells [1,2]. Two representativ...
m6A methylation dependent autophagy activation is required for anti-tumor effects of artesunate through ferroptosis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related death worldwi...
In-vitro and in-vivo CYP3A4 Variants: Neratinib metabolism and drug interaction risk
Cytochrome P450 3A4 (CYP3A4) is one of the most crucial enzymes in human drug metabolism and is responsible for metabolizi...
Are PFAS alternatives safer? A network toxicology analysis suggests comparable or novel risks for hypertensive disorders of pregnancy
Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic chemicals characterized by their exceptional chemical ...
Molecular actions of sepantronium bromide (YM155) on survivin-dependent cell death in cancer and beyond
Sepantronium bromide (YM155) emerged as one of the earliest small molecules designed to selectively suppress survivin (BIR...
Neurotoxicity and mechanism of metal and metal oxide nanoparticles
Nanomaterials are substances that have at least one dimension between 1 and 100 nm in the three-dimensional scale, which a...
Tris(1,3-dichloro-2-propyl) phosphate exacerbates Parkinsonian-like deficits in mice by targeting EPAS1 in the neurovascular unit: An integrated computational and experimental study
Organophosphate esters (OPEs) are organic esters of phosphoric acid containing either alkyl chains or aryl groups. Based o...
Mechanistic exploration of methylglyoxal-induced hepatotoxicity involving oxidative stress, apoptosis, and gluconeogenic modulation
Methylglyoxal (MG) is a highly reactive α-dicarbonyl compound found in the serum of diabetic patients. Its concentration r...
Differential toxicity of perfluorooctane sulfonate (PFOS) in wild-type and Oatp1d1 mutant zebrafish larvae
Per- and polyfluoroalkyl substances (PFAS) are a diverse group of man-made chemicals that have been widely used in various...
Demethoxycurcumin induces metabolic crisis and ATF4/ATF3/CHOP-dependent cell death in hepatocellular carcinoma
Liver cancer, particularly hepatocellular carcinoma (HCC), which accounts for 75 %–85 % of all liver cancer cases, is the ...
Protective effects of Ginkgolide B on myocardial ischemia reperfusion injury: role of the GAS6/Axl signaling pathway
Cardiovascular diseases, as a critical global public health challenge, have drawn extensive attention due to their high pr...
Arctigenin inhibits high glucose-induced EMT and cell proliferation to alleviate benign prostatic hyperplasia companied with type 2 diabetes mellitus through MBOAT4/ acylated Ghrelin/GHS-R
Benign prostatic hyperplasia (BPH) affects aging men worldwide, with the frequent clinical symptoms such as lower urinary ...
Characterization of a gene expression biomarker predictive of hypoxia-inducible factor-1 modulation
Hypoxia-inducible factor (HIF) is a sensor of hypoxia and a regulator of the cellular hypoxic response. HIF is composed of...
Comprehensive transcriptomic analysis in wild-type and ATM knockout lung cancer cells: Influence of cisplatin on oxidative stress-induced senescence
Genetic mutations and impaired DNA repair mechanisms in cancer not only facilitate tumor progression but also reduce the e...
Sulforaphane treatment of HL-60 cells protects against clozapine toxicity and protein covalent binding: implications for clozapine-induced agranulocytosis
Worldwide, schizophrenia is a significant public health concern because it affects neurotransmitter systems with changing ...
Fluorescent substrates enable specific detection and structure-function insights into human aldehyde dehydrogenase isoforms
Aldehyde dehydrogenase (ALDH) isoforms are widely used as biomarkers and potential drug targets in cancer research. Quanti...
Lowering exposures without considering biology and tradeoffs is not precautionary
Volume 418, 5 September 2025, 111613Author links open overlay panel, Highlights•Precautionary principle-based decisions re...
Effects of zearalenone on endoplasmic reticulum stress-induced apoptosis via global and gene-specific histone modifications and miRNA-mediated p53-signaling pathway in HEK-293 cells
Due to global climate change and growing environmental pollution, the likelihood of mycotoxin contamination in food and cr...
Incorporating alkylthio groups provides potent in vitro anticancer activity to water-soluble and aqueous-stable diiron(I) bis-cyclopentadienyl complexes
Transition metal complexes offer significant pharmacological advantages over conventional drugs, prompting extensive resea...
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