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Hypoglycaemia in Older Adults with Diabetes: Pathophysiology, Prevention, and Personalized Care in an Aging Population
Hypoglycaemia in Older Adults with Diabetes: Pathophysiology, Prevention, and Personalized Care in an Aging Population
Managing diabetes in older adults requires balancing long-term glycaemic control with the prevention of hypoglycaemia, to ...
Reduced-Dose Edoxaban in Patients Aged ≥ 80 Years: A Single-Center Real-World Analysis
Reduced-Dose Edoxaban in Patients Aged ≥ 80 Years: A Single-Center Real-World Analysis
Optimal anticoagulation strategies in octogenarians remain controversial owing to age-related risks of thromboembolism and...
Characteristics of Late-Onset Systemic Lupus Erythematosus: Clinical Manifestations and Diagnostic and Treatment Challenges
Characteristics of Late-Onset Systemic Lupus Erythematosus: Clinical Manifestations and Diagnostic and Treatment Challenges
Systemic lupus erythematosus (SLE) is widely recognized as a systemic autoimmune disease predominantly affecting young wom...
Anesthesia Considerations in Older Adults Undergoing Emergency Mechanical Thrombectomy for Acute Ischaemic Stroke
Anesthesia Considerations in Older Adults Undergoing Emergency Mechanical Thrombectomy for Acute Ischaemic Stroke
Acute ischemic stroke (AIS) is a significant cause of morbidity and mortality among older adults, with its incidence, seve...
Association of Antipsychotic Dose with Surrogate Efficacy and Safety Outcomes in Hospitalized Older Adults: A Retrospective Cohort Study
Association of Antipsychotic Dose with Surrogate Efficacy and Safety Outcomes in Hospitalized Older Adults: A Retrospective Cohort Study
Antipsychotics are frequently used in hospitalized older adults to manage agitation and delirium, despite limited supporti...
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies
Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes...
Frailty-Informed Pain Management: A Clinical Imperative Beyond Chronological Age
Frailty-Informed Pain Management: A Clinical Imperative Beyond Chronological Age
Chronic pain is a prevalent and disabling condition whose management becomes increasingly complex with aging and frailty. ...
Anti-hypertensive Drug Classes and Risk of New-Onset Atrial Fibrillation in Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial
Anti-hypertensive Drug Classes and Risk of New-Onset Atrial Fibrillation in Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial
Prior studies have suggested potential benefits of antihypertensive medication (AHM) in preventing atrial fibrillation. It...
Patterns and Characteristics of Gabapentin Use Among Medicare Beneficiaries
Patterns and Characteristics of Gabapentin Use Among Medicare Beneficiaries
Gabapentin is increasingly prescribed to older adults, yet prescribing patterns and characteristics of gabapentin initiato...
Effectiveness of Patient-Directed Education to Sustain Deprescribing: A Pragmatic Trial
Effectiveness of Patient-Directed Education to Sustain Deprescribing: A Pragmatic Trial
More than one in three older adults use potentially inappropriate medications (PIMs), and those with chronic conditions ar...
Trends and Guideline Adherence in Gabapentinoid Use among Geriatric Outpatients: A Retrospective Cross-Sectional Study at a Falls Clinic
Trends and Guideline Adherence in Gabapentinoid Use among Geriatric Outpatients: A Retrospective Cross-Sectional Study at a Falls Clinic
With pain treatment shifting away from opioids, alternative analgesics—such as gabapentinoids—are increasingly...
Inclusion of Older Adults in Early-Phase Cancer Clinical Trials: Safety, Efficacy and a Way Forward
Inclusion of Older Adults in Early-Phase Cancer Clinical Trials: Safety, Efficacy and a Way Forward
Early-phase clinical trials (EPCTs) are critical for evaluating the safety, tolerability, efficacy and pharmacokinetics of...
Initial Real-World Evidence for Lecanemab in the United States
Initial Real-World Evidence for Lecanemab in the United States
Lecanemab is the first anti-amyloid monoclonal antibody with full approval in the US for the treatment of early Alzheimer&...
Effectiveness of a Collaborative Deprescribing Intervention of Proton Pump Inhibitors on Community-Dwelling Older Adults: The C-SENIoR Pragmatic Non-randomised Controlled Trial
Effectiveness of a Collaborative Deprescribing Intervention of Proton Pump Inhibitors on Community-Dwelling Older Adults: The C-SENIoR Pragmatic Non-randomised Controlled Trial
Proton pump inhibitors (PPIs) are commonly used and often prescribed inappropriately, which increases the risk of adverse ...
Cross-Sectional Study on Factors Associated with Hyperpolypharmacy and Medication Adherence in Older Adults with Multimorbidity and Polypharmacy
Cross-Sectional Study on Factors Associated with Hyperpolypharmacy and Medication Adherence in Older Adults with Multimorbidity and Polypharmacy
Knowledge of multiple medication use and medication adherence is important to assess treatment effectiveness and prevent w...
Perioperative Anticholinergic Medication Use and Incident Dementia among Older Surgical Patients: a Retrospective Cohort Study using Real-World Data
Perioperative Anticholinergic Medication Use and Incident Dementia among Older Surgical Patients: a Retrospective Cohort Study using Real-World Data
Inpatient anticholinergic medications have been associated with a higher likelihood of postoperative delirium in older adu...
Safety Study of Anticoagulants for Preventing Deep Venous Thrombosis after Intracerebral Hemorrhage: Data from the Chinese Stroke Center Alliance
Safety Study of Anticoagulants for Preventing Deep Venous Thrombosis after Intracerebral Hemorrhage: Data from the Chinese Stroke Center Alliance
The use of anticoagulants to prevent deep vein thrombosis (DVT) after intracerebral hemorrhage (ICH) remains controversial...
Antidepressants to Manage Osteoarthritic Pain: The Value of Pain Phenotyping
Antidepressants to Manage Osteoarthritic Pain: The Value of Pain Phenotyping
Osteoarthritis (OA) is a chronic condition in which pain significantly affects quality of life, often leading to reduced p...
Unveiling Cognitive Impairment in Older Adults with Cancer on Systemic Anticancer Therapy: A Comprehensive Review
Unveiling Cognitive Impairment in Older Adults with Cancer on Systemic Anticancer Therapy: A Comprehensive Review
Cancer-related cognitive impairment significantly affects cancer management and decision-making. While the exact mechanism...
Factors Influencing General Practitioners’ Deprescribing Decisions for Older Adults, with Insights into Frailty: a Qualitative Study in Greek Primary Care
Factors Influencing General Practitioners’ Deprescribing Decisions for Older Adults, with Insights into Frailty: a Qualitative Study in Greek Primary Care
Polypharmacy is increasing among older individuals worldwide. Deprescribing has been suggested as a strategy to reduce pol...
Safety and Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Older Adults with Variable Disease States: A Meta-analysis of Large Placebo-Controlled Trials
Safety and Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Older Adults with Variable Disease States: A Meta-analysis of Large Placebo-Controlled Trials
Recent guidelines recommend the use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors (SGLT2i) in patients suffering f...
Dementia Medications and Their Association with Pain Medication Use in Medicare Beneficiaries with Alzheimer’s Disease/Alzheimer’s Disease-Related Dementias and Chronic Pain
Dementia Medications and Their Association with Pain Medication Use in Medicare Beneficiaries with Alzheimer’s Disease/Alzheimer’s Disease-Related Dementias and Chronic Pain
Chronic pain is prevalent among older adults with Alzheimer’s disease (AD) and Alzheimer’s disease-related dem...
Trazodone and Risk of Orthostatic Hypotension, Syncope and Falls in Geriatric Outpatients with Hypertension
Trazodone and Risk of Orthostatic Hypotension, Syncope and Falls in Geriatric Outpatients with Hypertension
In older adults, trazodone is frequently prescribed for anxiety and insomnia owing to its perceived greater tolerability i...
Medicine Optimisation and Deprescribing Intervention Outcomes for Older People with Dementia or Mild Cognitive Impairment: A Systematic Review
Medicine Optimisation and Deprescribing Intervention Outcomes for Older People with Dementia or Mild Cognitive Impairment: A Systematic Review
Polypharmacy is common amongst older people with dementia or mild cognitive impairment (MCI), increasing the risk of medic...
Impact of Disease-Modifying Antirheumatic Drugs on Cognitive Function in Older Adults with Rheumatoid Arthritis
Impact of Disease-Modifying Antirheumatic Drugs on Cognitive Function in Older Adults with Rheumatoid Arthritis
Cognitive impairment poses significant challenges for aging populations. Systemic inflammation, a hallmark of rheumatoid a...
Prescription and Non-prescription Medication Pill Burdens and Their Associations with Health-Related Quality of Life in Older Adults: A Cross-Sectional Study
Prescription and Non-prescription Medication Pill Burdens and Their Associations with Health-Related Quality of Life in Older Adults: A Cross-Sectional Study
Polypharmacy is associated with reduced health-related quality of life (HRQoL). This study explores the association betwee...
International Deprescribing Guidelines Did Not Impact Actual Practice in Deprescribing of Potentially Inappropriate Medications for Nursing Home Residents: An Interrupted Time Series Analysis
International Deprescribing Guidelines Did Not Impact Actual Practice in Deprescribing of Potentially Inappropriate Medications for Nursing Home Residents: An Interrupted Time Series Analysis
Deprescribing guidelines reduce the use of potentially inappropriate medications (PIMs) in trial settings; however, their ...
Symptoms of Orthostatic Hypotension and Drugs Affecting Autonomic Function are Associated with the Onset of Frailty in Community-Dwelling Persons Aged 80 Years and Above: A Prospective Observational Study
Symptoms of Orthostatic Hypotension and Drugs Affecting Autonomic Function are Associated with the Onset of Frailty in Community-Dwelling Persons Aged 80 Years and Above: A Prospective Observational Study
Both autonomic dysfunction and frailty are common and complex geriatric syndromes with similar negative health outcomes. B...
Benefit–Risk Assessment of Rivaroxaban in Older Patients With Nonvalvular Atrial Fibrillation or Venous Thromboembolism
Benefit–Risk Assessment of Rivaroxaban in Older Patients With Nonvalvular Atrial Fibrillation or Venous Thromboembolism
Both bleeding and adverse ischemic events increase with age, compounding the benefit–risk balance of anticoagulants ...
Detection of Potential Prescribing Cascades in Multimorbid Older Patients Hospitalised with Acute Illness—An Observational Prospective Prevalence Study
Detection of Potential Prescribing Cascades in Multimorbid Older Patients Hospitalised with Acute Illness—An Observational Prospective Prevalence Study
Prescribing cascades occur when a new drug is prescribed to treat an adverse drug event caused by an existing medication, ...
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